<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2025-1122</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-1122</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности курса лазерной терапии при реабилитации пациентов с диагнозом «В00.2 Герпетический гингивостоматит»</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy of a course of photobiomodulation for the management of B00.2 Herpetic Gingivostomatitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5846-5578</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романенко</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanenko</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романенко Наталья Валерьевна, кандидат медицинских наук, доцент, доцент кафедры хирургической стоматологии Института стоматологии имени Е. В. Боровского</p><p>119048, ул. Трубецкая, д. 8, стр. 2, Москва</p></bio><bio xml:lang="en"><p>Natalia V. Romanenko, DMD, PhD, Associate Professor, Department of the Oral Surgery, E. V. Borovsky Institute of Dentistry</p><p>8–2 Trubetskaya Str., Moscow, 119048</p></bio><email xlink:type="simple">romanenko.natalia@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-4707-1051</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аяяди</surname><given-names>Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ayyadi</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аяяди Нур, клинический ординатор кафедры хирургической стоматологии Института стоматологии имени Е. В. Боровского</p><p>Москва</p></bio><bio xml:lang="en"><p>Nour Ayyadi, DMD, Clinical Resident, Department of the Oral Surgery, E. V. Borovsky Institute of Dentistry</p><p>Moscow </p></bio><email xlink:type="simple">ayadin097@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-5693-1335</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уляшева</surname><given-names>Ж. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Uliasheva</surname><given-names>Zh. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уляшева Жанна Андреевна, студент Института стоматологии имени Е. В. Боровского</p><p>Москва</p></bio><bio xml:lang="en"><p>Zhanna A. Uliasheva, Student, Department of the Oral Surgery, E. V. Borovsky Institute of Dentistry</p><p>Moscow </p></bio><email xlink:type="simple">zhanna.ulyasheva.2003@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5839-7915</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Благушина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Blagushina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Благушина Наталия Алексеевна, кандидат медицинских наук, ассистент кафедры хирургической стоматологии Института стоматологии имени Е. В. Боровского</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia A. Blagushina, DMD, PhD, Assistant Professor Department of the Oral Surgery, E. V. Borovsky Institute of Dentistry</p><p>Moscow </p></bio><email xlink:type="simple">blagushina.natalia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет имени И. М. Сеченова (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>08</day><month>11</month><year>2025</year></pub-date><volume>30</volume><issue>3</issue><fpage>321</fpage><lpage>335</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Романенко Н.В., Аяяди Н., Уляшева Ж.А., Благушина Н.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Романенко Н.В., Аяяди Н., Уляшева Ж.А., Благушина Н.А.</copyright-holder><copyright-holder xml:lang="en">Romanenko N.V., Ayyadi N., Uliasheva Z.A., Blagushina N.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/1122">https://www.parodont.ru/jour/article/view/1122</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Герпетический гингивостоматит – одно из распространенных заболеваний, вызываемых вирусом простого герпеса I типа. Наличие вторничных элементов поражения слизистой оболочки полости рта герпесом характеризуется выраженным болевым синдромом и снижением качества жизни пациентов в связи с ограничением приема пищи и активности речи. Актуальным представилось определение возможности применения лазерного излучения в качестве немедикаментозного метода лечения пациентов с диагнозом «В00.2 Герпетический гингивостоматит».</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Клиническое исследование проведено у 24 пациентов с диагнозом «В00.2 Герпетический гингивостоматит» со средним возрастом 31,10 ± 8,72 лет (медиана – 28,5 лет; 24, 35,5); 75% наблюдений составили женщины (n = 18). Воздействие лазерным излучением на очаги поражения слизистой оболочки полости рта проводили трехкратно по 1 минуте неинициированными волокнами лазерных аппаратов ALTA BLUE (I группа пациентов, n = 12) и PICASSO lite (II группа пациентов, n = 12) бесконтактным способом с соблюдением расстояния 4,5–5 мм от кончика световода до элементов поражения и динамической методикой в виде спиралевидных движений при начальной мощности 0,5 Вт и непрерывном режиме. Для оценки клинической ситуации у пациентов применяли цифровую рейтинговую шкалу от 0 до 10 для определения болевых ощущений до лечения и после сеансов низкоинтенсивной лазерной терапии в течение 5 суток. Статистический анализ выполнен с использованием среды программирования R 4.5.0.</p></sec><sec><title>Результаты</title><p>Результаты. При первичном обращении пациентов средний показатель боли в области очагов поражения составил 7,79 ± 1,41 балла [8; 7, 9]. Статистически значимых отличий между группами в отношении динамики боли установлено не было (p = 0,386). После 1й минуты воздействия лазерным излучением на область поражения в 75% случаев наблюдения пациенты отмечали ощущение поверхностной анестезии и указывали на устранение боли. В 100% случаев наблюдения пациенты отмечали значительное улучшение общего самочувствия после проведения I сеанса НИЛТ. Данные клинического осмотра указывали на уменьшение выраженности отека и гиперемии слизистой оболочки полости рта.</p></sec><sec><title>Заключение</title><p>Заключение. Применение лазерного излучения длиной волн 445 нм и 810 нм является эффективным способом при устранении клинических симптомов герпетического гингивостоматита.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Herpetic gingivostomatitis (ICD-10: B00.2) is a common condition representing the primary clinical manifestation of herpes simplex virus type 1 (HSV-1) infection. Herpetic lesions of the oral mucosa are associated with severe pain and a marked reduction in quality of life due to difficulty eating and speaking. The aim of this study was to evaluate the potential of laser radiation as a non-pharmacological treatment modality for patients diagnosed with herpetic gingivostomatitis.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. A clinical study was conducted in 24 patients diagnosed with B00.2 herpetic gingivostomatitis (mean age, 31.1 ± 8.7 years [median, 28.5 years; IQR, 24–35.5 years]). Women comprised 75% of the sample (n = 18). Lesion sites on the oral mucosa were exposed to laser radiation on three occasions, 60 s per application, using non-initiated fibers attached to diode laser units ALTA BLUE (Group I, n = 12) and PICASSO lite (Group II, n = 12). Procedures were performed in a non-contact technique, maintaining a 4.5–5 mm standoff from the fiber tip to the lesion and employing a spiral scanning motion, with an initial output power of 0.5 W in continuous-wave mode. Pain intensity was recorded on a numerical rating scale (NRS-11, 0–10) before treatment and after each session over a 5-day course of photobiomodulation (low-level laser therapy, LLLT). Statistical analysis was performed in R, version 4.5.0.</p></sec><sec><title>Results</title><p>Results. At baseline, the mean pain score at lesion sites was 7.8 ± 1.4 [median, 8.0; IQR, 7–9]. No statistically significant intergroup differences were detected in pain-reduction dynamics (p = 0.386). After the first minute of laser exposure, 75% of patients reported a sensation of superficial anesthesia with resolution of pain. Following the initial photobiomodulation session, 100% of patients reported a marked improvement in overall well-being. Clinical examination demonstrated a reduction in edema and hyperemia of the oral mucosa.</p></sec><sec><title>Conclusion</title><p>Conclusion. Laser radiation at 445 nm and 810 nm is an effective modality for alleviating the clinical symptoms of herpetic gingivostomatitis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>низкоинтенсивная лазерная терапия</kwd><kwd>герпес слизистой оболочки полости рта</kwd><kwd>синий лазер</kwd><kwd>лазерное излучение длиной волны 445 нм</kwd><kwd>лазерное излучение длиной волны 810 нм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>photobiomodulation</kwd><kwd>low-level laser therapy</kwd><kwd>oral herpes</kwd><kwd>blue laser</kwd><kwd>445-nm laser radiation</kwd><kwd>810-nm laser radiation</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы заявляют об отсутствии внешнего финансирования при проведении исследования.</funding-statement><funding-statement xml:lang="en">The authors declare that there was no external funding for the study.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bojović M, Kesić L, Jovanović G, Burić N, Savić Z, Obradović R, Petrović MS. Application of soft laser in the treatment of herpes labialis – pilot study. Acta Stomatol Naissi. 2014;30(69):1342–1347. https://doi.org/10.5937/ASN1469342B</mixed-citation><mixed-citation xml:lang="en">Bojović M, Kesić L, Jovanović G, Burić N, Savić Z, Obradović R, et al. Application of soft laser in the treatment of herpes labialis – pilot study. Acta Stomatol Naissi. 2014;30(69):1342–1347. https://doi.org/10.5937/ASN1469342B</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Притыко ДА, Сергеенко ЕЮ, Тимохин ЕВ, Савлаев КФ, Гусев ЛИ. Перспективы применения лазерной терапии при лечении оральных мукозитов у детей (обзор литературы). Стоматология детского возраста и профилактика. 2018;17(1):14–17. Режим доступа: https://www.detstom.ru/jour/article/view/116/117</mixed-citation><mixed-citation xml:lang="en">Prityko DA, Sergeenko EYu, Timokhin EV, Savlaev KF, Gusev LI. Prospects of the use of laser therapy treatment of oral mukosites in children (literature review). Pediatric dentistry and dental prophylaxis. 2018;17(1):14–17 (In Russ.). Available from: https://www.detstom.ru/jour/article/view/116/117</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">de Paula Eduardo C, Aranha AC, Simões A, et al. Laser treatment of recurrent herpes labialis: a literature review. Lasers in Medical Sciences. 2014;29(4):1517–1529. https://doi.org/10.1007/s10103-013-1311-8</mixed-citation><mixed-citation xml:lang="en">de Paula Eduardo C, Aranha AC, Simões A, et al. Laser treatment of recurrent herpes labialis: a literature review. Lasers in Medical Sciences. 2014;29(4):1517–1529. https://doi.org/10.1007/s10103-013-1311-8</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Seyyedi SA, Gobaran ZM, Yekani S, Taram S. Efficacy of adjuvant photobiomodulation therapy in recurrent herpes labialis, a randomized clinical trial study. Photodiagnosis Photodyn Ther. 2024;49:104282. https://doi.org/10.1016/j.pdpdt.2024.104282</mixed-citation><mixed-citation xml:lang="en">Seyyedi SA, Gobaran ZM, Yekani S, Taram S. Efficacy of adjuvant photobiomodulation therapy in recurrent herpes labialis, a randomized clinical trial study. Photodiagnosis Photodyn Ther. 2024;49:104282. https://doi.org/10.1016/j.pdpdt.2024.104282</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Donnarumma G, De Gregorio V, Fusco A, Farina E, Baroni A, Esposito V, et al. Inhibition of HSV–1 replication by laser diode–irradiation: possible mechanism of action. International journal of immunopathology and pharmacology. 2010;23(4):1167–1176. https://doi.org/10.1177/039463201002300420</mixed-citation><mixed-citation xml:lang="en">Donnarumma G, De Gregorio V, Fusco A, Farina E, Baroni A, Esposito V, et al. Inhibition of HSV–1 replication by laser diode–irradiation: possible mechanism of action. International journal of immunopathology and pharmacology. 2010;23(4):1167–1176. https://doi.org/10.1177/039463201002300420</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Москвин СВ, Чернова НИ. Лазерная терапия при герпесвирусных инфекциях (обзор литературы). Вестник новых медицинских технологий. Электронное издание. 2019;(4):122–137. https://doi.org/10.24411/2075-4094-2019-16467</mixed-citation><mixed-citation xml:lang="en">Moskvin SV, Chernova NI. Laser therapy for herves virus infections (literature review). Journal of new medical technologies, eEdition. 2019;4:122–137 (In Russ.). https://doi.org/10.24411/2075-4094-2019-16467</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fabre HS, Navarro RL, Oltramari–Navarro PV, Oliveira RF, Pires–Oliveira DA, Andraus RA, et al. Anti–inflammatory and analgesic effects of low–level laser therapy on the postoperative healing process. Journal of physical therapy science. 2015;27(6):1645–1648. https://doi.org/10.1589/jpts.27.1645</mixed-citation><mixed-citation xml:lang="en">Fabre HS, Navarro RL, Oltramari–Navarro PV, Oliveira RF, Pires–Oliveira DA, Andraus RA, et al. Anti–inflammatory and analgesic effects of low–level laser therapy on the postoperative healing process. Journal of physical therapy science. 2015;27(6):1645–1648. https://doi.org/10.1589/jpts.27.1645</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Романенко НВ, Тульских ЕВ, Кирсанова НМ, Тарасенко СВ. Определение эффективности воздействия низкоинтенсивным лазерным излучением длиной волны 445 нм на область десны по данным лазерной допплеровской флоуметрии. Клиническая практика. 2025;16(1):38–46. https://doi.org/10.17816/clinpract677229</mixed-citation><mixed-citation xml:lang="en">Romanenko NV, Tulskikh EV, Kirsanova NM, Tarasenko SV. Determining the efficiency of lowintensity laser radiation exposure with a wavelength of 445 nm appliied to the gingival area according to the data from laser doppler flowmetry. Journal of Clinical Practice. 2025;16(1):38–46 (In Russ.). https://doi.org/10.17816/clinpract677229</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Palaia G, Pergolini D, D'Alessandro L, Carletti R, Del Vecchio A, Tenore G, Di Gioia CRT, Romeo U. Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy. International Journal of Environmental Research and Public Health. 2020;17(8):2651. https://doi.org/10.3390/ijerph17082651</mixed-citation><mixed-citation xml:lang="en">Palaia G, Pergolini D, D'Alessandro L, Carletti R, Del Vecchio A, Tenore G, et al. Histological Effects of an Innovative 445 Nm Blue Laser During Oral Soft Tissue Biopsy. International Journal of Environmental Research and Public Health. 2020;17(8):2651. https://doi.org/10.3390/ijerph17082651</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Романенко НВ, Суворов АЮ, Благушина НА, Смирнов АА, Тарасенко СВ. Применение лазерного излучения длиной волны 445 nm для гемостаза в области донорской зоны твердого неба. Пародонтология. 2025;30(1):56–66. https://doi.org/10.33925/1683-3759-2025-1054</mixed-citation><mixed-citation xml:lang="en">Romanenko NV, Suvorov AYu, Blagushina NA, Smirnov AA, Tarasenko SV. Hemostasis in the donor area of the hard palate using 445 nm wavelength laser radiation. Parodontologiya. 2025;30(1):56–66 (In Russ.). https://doi.org/10.33925/1683-3759-2025-1054</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Mujić Jahić I, Gojkov Vukelić M, Hadžić S, Pašić E, Muharemović A, Salihefendić L, et al. A Novel Blue Light Laser (445 nm) in Non-surgical Treatment of Chronic Periodontitis: A Clinical and Microbiological Study. Cureus. 2024;16(8):e67252. https://doi.org/10.7759/cureus.67252</mixed-citation><mixed-citation xml:lang="en">Mujić Jahić I, Gojkov Vukelić M, Hadžić S, Pašić E, Muharemović A, Salihefendić L, et al. A Novel Blue Light Laser (445 nm) in Non-surgical Treatment of Chronic Periodontitis: A Clinical and Microbiological Study. Cureus. 2024;16(8):e67252. https://doi.org/10.7759/cureus.67252</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Moulton PF, Cederberg JG, Stevens KT, Foundos G, Koselja M, Preclikova J. Optimized InGaN-diode pumping of Ti:sapphire crystals. Optical Materials Express. 2019;9(5):2131. https://doi.org/10.1364/ome.9.002131</mixed-citation><mixed-citation xml:lang="en">Moulton PF, Cederberg JG, Stevens KT, Foundos G, Koselja M, Preclikova J. Optimized InGaN-diode pumping of Ti:sapphire crystals. Optical Materials Express. 2019;9(5):2131. https://doi.org/10.1364/ome.9.002131</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zupin L, Caracciolo I, Tricarico PM, Ottaviani G, D'Agaro P, Crovella S. Antiviral properties of blue laser in an in vitro model of HSV–1 infection. Microbiology and immunology, 2018; Advance online publication https://doi.org/10.1111/1348-0421.12600</mixed-citation><mixed-citation xml:lang="en">Zupin L, Caracciolo I, Tricarico PM, Ottaviani G, D'Agaro P, Crovella S. Antiviral properties of blue laser in an in vitro model of HSV–1 infection. Microbiology and immunology, 2018; Advance online publication: https://doi.org/10.1111/1348-0421.12600</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zupin L, Crovella S. Blue Laser Light Counteracts HSV–1 in the SH–SY5Y Neuronal Cell Model of Infection. Life (Basel). 2022;12(1):55. https://doi.org/10.3390/life12010055</mixed-citation><mixed-citation xml:lang="en">Zupin L, Crovella S. Blue Laser Light Counteracts HSV–1 in the SH–SY5Y Neuronal Cell Model of Infection. Life (Basel). 2022;12(1):55. https://doi.org/10.3390/life12010055</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Moskvin SV. Low–Level Laser Therapy for Herpesvirus Infections: A Narrative Literature Review: LLLT for herpesvirus. Journal of Lasers in Medical Sciences. 2021;12:e38. https://doi.org/10.34172/jlms.2021.38</mixed-citation><mixed-citation xml:lang="en">Moskvin SV. Low–Level Laser Therapy for Herpesvirus Infections: A Narrative Literature Review: LLLT for herpesvirus. Journal of Lasers in Medical Sciences. 2021;12:e38. https://doi.org/10.34172/jlms.2021.38</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Al–Maweri SA, Kalakonda B, AlAizari NA, Al–Soneidar WA, Ashraf S, Abdulrab S, et al. Efficacy of low–level laser therapy in management of recurrent herpes labialis: a systematic review. Lasers in Medical Sciences. 2018;33(7):1423–1430. https://doi.org/10.1007/s10103-018-2542-5</mixed-citation><mixed-citation xml:lang="en">Al–Maweri SA, Kalakonda B, AlAizari NA, Al–Soneidar WA, Ashraf S, Abdulrab S, et al. Efficacy of low–level laser therapy in management of recurrent herpes labialis: a systematic review. Journal of Lasers in Medical Sciences. 2018;33(7):1423–1430. https://doi.org/10.1007/s10103-018-2542-5</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Barros AWP, Sales PHDH, Silva PGB, Gomes ACA, Carvalho AAT, Leão JC. Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta–analysis. Lasers in Medical Sciences. 2022;37(9):3393–3402. https://doi.org/10.1007/s10103-022-03653-6</mixed-citation><mixed-citation xml:lang="en">Barros AWP, Sales PHDH, Silva PGB, Gomes ACA, Carvalho AAT, Leão JC. Is low-level laser therapy effective in the treatment of herpes labialis? Systematic review and meta–analysis. Lasers in Medical Sciences. 2022;37(9):3393–3402. https://doi.org/10.1007/s10103-022-03653-6</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Крылова ИА, Фабрикантов ОЛ, Яблокова НВ. Сравнительная эффективность субпорогового микроимпульсного лазерного воздействия 810 и 577 нм при диабетическом макулярном отеке. Современные технологии в офтальмологии. 2019;(1):369–372. https://doi.org/10.25276/2312-4911-2019-1-369-372</mixed-citation><mixed-citation xml:lang="en">Krylova AA, Fabrikantov OL, Yablokova NV. Comparative efficacy of subthreshold micropulse laser 810 nm and 577 nm in diabetic macular edema. Modern technologies in ophthalmology. 2019;1:369–372 (In Russ.). https://doi.org/10.25276/2312-4911-2019-1-369-372</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmadi M, Shirani AM, Farhad SZ, Khosravi M, Mir M. Comparison of 660–nm low–level and defocused 810–nm high–power laser for treatment of herpes labialis. Laser Dent Sci. 2022;6:211–218. https://doi.org/10.1007/s41547-022-00164-z</mixed-citation><mixed-citation xml:lang="en">Ahmadi M, Shirani AM, Farhad SZ, Khosravi M, Mir M. Comparison of 660–nm low–level and defocused 810–nm high–power laser for treatment of herpes labialis. Laser Dent Sci. 2022;6:211–218. https://doi.org/10.1007/s41547-022-00164-z</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Moskvin SV. Low–Level Laser Therapy in Russia: History, Science and Practice. Lasers in Medical Sciences. 2017;8:56–65. https://doi.org/10.15171/jlms.2017.11</mixed-citation><mixed-citation xml:lang="en">Moskvin S.V. Low–Level Laser Therapy in Russia: History, Science and Practice. Lasers in Medical Sciences. 2017;8:56–65. https://doi.org/10.15171/jlms.2017.11</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Huang YY, Sharma SK, Carroll J, Hamblin MR. Biphasic dose response in low level light therapy – an update. Dose Response. 2011;9(4):602–618. https://doi.org/10.2203/dose-response.11-009.Hamblin</mixed-citation><mixed-citation xml:lang="en">Huang YY, Sharma SK, Carroll J, Hamblin MR. Biphasic dose response in low level light therapy – an update. Dose Response. 2011;9(4):602–618. https://doi.org/10.2203/dose-response.11-009.Hamblin</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Романенко НВ, Тарасенко СВ, Сережникова НБ, Шехтер АБ, Суворов АЮ, Джиджавадзе СВ, и др. Сравнительная оценка результатов биологического ответа слизистой оболочки полости рта на воздействие лазерным излучением с длиной волны 445 и 810 нм (экспериментальное исследование). Клиническая стоматология. 2022;25(4):137–143. https://doi.org/10.37988/1811-153X_2022_4_137</mixed-citation><mixed-citation xml:lang="en">Romanenko NV, Tarasenko SV, Serezhnikova NB, Shekhter AB, Suvorov AY, Djidjavadze SV, et al. A comparative assessment of the results of the biological response of the oral mucosa on the effect of laser radiation with a wavelength of 445 nm and 810 nm. Clinical Dentistry (Russia). 2022;25(4):137–143 (In Russ.). https://doi.org/10.37988/1811-153X_2022_4_137</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Honarmand M, Farhadmollashahi L, Vosoughirahbar E. Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis. Journal of clinical and experimental dentistry. 2017;9(6):e729–e732. https://doi.org/10.4317/jced.53679</mixed-citation><mixed-citation xml:lang="en">Honarmand M, Farhadmollashahi L, Vosoughirahbar E. Comparing the effect of diode laser against acyclovir cream for the treatment of herpes labialis. Journal of clinical and experimental dentistry. 2017;9(6):e729–e732. https://doi.org/10.4317/jced.53679</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Sahib Nadia H, Salih, Ayam Mohammed; Fakhry, Fatin Ahmed; Al-Hattab, Mhammed K. Treatment of Herpes Labialis Virus by Low–Level Laser Therapy in Comparison with Acyclovir Cream. Medical Journal of Babylon. 2025;22(1):289–293. https://doi.org/10.4103/MJBL.MJBL_815_23</mixed-citation><mixed-citation xml:lang="en">Sahib Nadia H, Salih, Ayam Mohammed; Fakhry, Fatin Ahmed; Al-Hattab, Mhammed K. Treatment of Herpes Labialis Virus by Low–Level Laser Therapy in Comparison with Acyclovir Cream. Medical Journal of Babylon. January–March 2025;22(1):289–293. https://doi.org/10.4103/MJBL.MJBL_815_23</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Senti G, Iannaccone R, Graf N, Felder M, Tay F, Kündig T. A randomized, double-blind, placebo-controlled study to test the efficacy of topical 2-hydroxypropyl-Beta-cyclodextrin in the prophylaxis of recurrent herpes labialis. Dermatology. 2013;226(3):247–252. https://doi.org/10.1159/000349991</mixed-citation><mixed-citation xml:lang="en">Senti G, Iannaccone R, Graf N, Felder M, Tay F, Kündig T. A randomized, double-blind, placebo-controlled study to test the efficacy of topical 2-hydroxypropyl-Beta-cyclodextrin in the prophylaxis of recurrent herpes labialis. Dermatology. 2013;226(3):247–252. https://doi.org/10.1159/000349991</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">McQuillan G, Kruszon D. Age–adjusted trends in the prevalence of herpes simplex virus type 1 (HSV–1) and herpes simplex virus type 2 (HSV–2) among adolescents and adults aged 14–49 years–united states,1999–2000 through 2015–2016. Morb Mortal Wkly Rep. 2018;67:203. https://doi.org/10.15585/mmwr.mm6706a7</mixed-citation><mixed-citation xml:lang="en">McQuillan G, Kruszon D. Age–adjusted trends in the prevalence of herpes simplex virus type 1 (HSV–1) and herpes simplex virus type 2 (HSV–2) among adolescents and adults aged 14–49 years–united states,1999–2000 through 2015–2016. Morb Mortal Wkly Rep. 2018;67:203. https://doi.org/10.15585/mmwr.mm6706a7</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. https://doi.org/10.1109/JSTQE.2016.2561201</mixed-citation><mixed-citation xml:lang="en">de Freitas LF, Hamblin MR. Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy. IEEE J Sel Top Quantum Electron. 2016;22(3):7000417. https://doi.org/10.1109/JSTQE.2016.2561201</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T. Pre-Irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg. 2008;107(3):1058-1063. https://doi.org/10.1213/ane.0b013e31817ee43e</mixed-citation><mixed-citation xml:lang="en">Hagiwara S, Iwasaka H, Hasegawa A, Noguchi T. Pre-Irradiation of blood by gallium aluminum arsenide (830 nm) low-level laser enhances peripheral endogenous opioid analgesia in rats. Anesth Analg. 2008;107(3):1058-1063. https://doi.org/10.1213/ane.0b013e31817ee43e</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira FC, Parisi JR, Maglioni CB, et al. Antinociceptive effects of low-level laser therapy at 3 and 8 j/cm 2 in a rat model of postoperative pain: possible role of endogenous Opioids. Lasers in Medical Sciences. 2017;49(9):844–851. https://doi.org/10.1002/lsm</mixed-citation><mixed-citation xml:lang="en">Pereira FC, Parisi JR, Maglioni CB, et al. Antinociceptive effects of low-level laser therapy at 3 and 8 j/cm 2 in a rat model of postoperative pain: possible role of endogenous Opioids. Lasers in Medical Sciences. 2017;49(9):844–851. https://doi.org/10.1002/lsm</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rocca JP, Zhao M, Fornaini C, Tan L, Zhao Z, Merigo E. Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison. J Photochem Photobiol B. 2018;189:1–4. https://doi.org/10.1016/j.jphotobiol.2018.09.016</mixed-citation><mixed-citation xml:lang="en">Rocca JP, Zhao M, Fornaini C, Tan L, Zhao Z, Merigo E. Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison. J Photochem Photobiol B. 2018;189:1–4. https://doi.org/10.1016/j.jphotobiol.2018.09.016</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
