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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2025-1182</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-1182</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Влияние применения профилактической зубной пасты, обогащенной макро- и микроэлементами, на элементный состав ротовой жидкости у пациентов с соматической патологией</article-title><trans-title-group xml:lang="en"><trans-title>Influence of a mineral-enriched preventive toothpaste on the elemental composition of saliva in patients with systemic diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6211-6453</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матвеева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Matveeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Матвеева Екатерина Владимировна - младший научный сотрудник отдела современных стоматологических технологий Научно-исследовательского института стоматологии и челюстно-лицевой хирургии.</p><p> 97000, ул. Льва Толстого, д. 6-8, Санкт-Петербург</p></bio><bio xml:lang="en"><p>Ekaterina V. Matveeva - Junior Researcher, Department of the Modern Dental Technologies, Research Institute of Dentistry and Oral and Maxillofacial Surgery.</p><p>6-8 Lev Tolstoy St., 97000, Saint Petersburg</p></bio><email xlink:type="simple">doktor.katerinka@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2543-6137</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антонова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Antonova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антонова Ирина Николаевна - доктор медицинских наук, профессор, директор Научно-исследовательского института стоматологии и челюстно-лицевой хирургии, заведующая кафедрой пропедевтики стоматологических заболеваний.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Irina N. Antonova - DМD, PhD, DSc, Professor, Director, Research Institute of Dentistry and Oral and Maxillofacial Surgery, Head of the Department of Preclinical Dentistry of dental diseases.</p><p>Saint Petersburg</p></bio><email xlink:type="simple">irina.antonova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>10</day><month>02</month><year>2026</year></pub-date><volume>30</volume><issue>4</issue><fpage>441</fpage><lpage>447</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Матвеева Е.В., Антонова И.Н., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Матвеева Е.В., Антонова И.Н.</copyright-holder><copyright-holder xml:lang="en">Matveeva E.V., Antonova I.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/1182">https://www.parodont.ru/jour/article/view/1182</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Одним из перспективных направлений профилактики стоматологических заболеваний является использование лечебно-профилактических зубных паст, обогащенных биодоступными формами эссенциальных элементов. Однако эффективность таких паст и их влияние на элементный гомеостаз ротовой жидкости у пациентов с коморбидной соматической патологией изучены недостаточно.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено изучение влияния профилактической зубной пасты, обогащенной макрои микроэлементами, на динамику концентрации кальция (Ca), меди (Cu), железа (Fe), магния (Mg), фосфора (P) и цинка (Zn) в ротовой жидкости в трех группах пациентов по 25 человек в каждой: 1) хроническая патология почек; 2) патология сердечно-сосудистой системы; 3) патология желудочно-кишечного тракта. Образцы ротовой жидкости исследовали методом электротермической атомно-абсорбционной спектрометрии на спектрометре «КВАНТ.Z.1» («КОРТЭК», Россия) с графитовой печью в динамике: до чистки зубов, сразу после чистки зубов, через 5 минут, 30 минут и 60 минут после чистки зубов.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что однократное использование исследуемой зубной пасты приводит к статистически значимым кратковременным изменениям элементного состава ротовой жидкости, которые варьируют в зависимости от соматической патологии. Наиболее выраженные статистически значимые изменения были получены для макроэлементов – кальция и магния и микроэлементов – меди и цинка. Заключение. Результаты свидетельствуют о необходимости учета соматического статуса пациента при подборе средств индивидуальной гигиены полости рта.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. One of the promising approaches to the prevention of oral diseases involves the use of preventive toothpastes enriched with bioavailable essential minerals. However, the effectiveness of such formulations and their impact on salivary mineral balance in patients with concomitant systemic diseases remain insufficiently investigated.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The effect of a preventive toothpaste enriched with macroand trace elements on changes in salivary concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorus (P), and zinc (Zn) was evaluated in three groups of patients (25 individuals per group): (1) chronic kidney disease, (2) cardiovascular disease, and (3) gastrointestinal disorders. Saliva samples were analyzed using electrothermal atomic absorption spectrometry with a graphite furnace (KVANT.Z.1 spectrometer, Kortek, Russia). Measurements were performed at the following time points: before tooth brushing, immediately after brushing, and 5, 30, and 60 minutes postbrushing.</p></sec><sec><title>Results</title><p>Results. Single use of the tested toothpaste resulted in statistically significant short-term alterations in the elemental composition of saliva, with patterns varying depending on the underlying systemic condition. The most pronounced statistically significant changes were observed for calcium and magnesium, as well as for the trace elements copper and zinc.</p></sec><sec><title>Conclusion</title><p>Conclusion. The findings indicate the importance of considering the patient’s systemic health status when selecting individual oral hygiene products.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ротовая жидкость</kwd><kwd>элементный состав</kwd><kwd>зубная паста</kwd><kwd>макроэлементы</kwd><kwd>микроэлементы</kwd><kwd>соматическая патология</kwd><kwd>атомно-абсорбционная спектрометрия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>saliva</kwd><kwd>salivary mineral composition</kwd><kwd>preventive toothpaste</kwd><kwd>essential minerals</kwd><kwd>trace elements</kwd><kwd>systemic diseases</kwd><kwd>atomic absorption spectrometry</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Индивидуальные благодарности для декларирования отсутствуют</funding-statement><funding-statement xml:lang="en">The authors declare that there was no external funding for the study. 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