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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">periodontology-189</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Особенности процессов иммунной регуляции в тканях пародонта у лиц, находящихся на ортодонтическом лечении</article-title><trans-title-group xml:lang="en"><trans-title>Peculiarities of immune regulation processes in periodontal tissues in patients undergoing orthodontic treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блашкова</surname><given-names>С.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мустафин</surname><given-names>И.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Халиуллина</surname><given-names>Г.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Казанский государственный медицинский университет</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>04</day><month>04</month><year>2019</year></pub-date><volume>21</volume><issue>3</issue><fpage>23</fpage><lpage>26</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Блашкова С., Мустафин И., Халиуллина Г., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Блашкова С., Мустафин И., Халиуллина Г.</copyright-holder><copyright-holder xml:lang="en">Блашкова С., Мустафин И., Халиуллина Г.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/189">https://www.parodont.ru/jour/article/view/189</self-uri><abstract><p>В статье представлены исследование клинико-иммунологического статуса 97 пациентов с разными видами ортодонтической патологии до начала и на этапах ортодонтического лечения. Всем пациентам проводилось иммунологическое обследование, включавшее определение уровня антимикробного пептида и провоспалительного цитокина. В ходе исследования было установлено, что наряду с клиническим методами целесообразно определять уровень α-дефензина и IL-1β, выполняющих функцию регулятора иммунологических процессов при воспалительных заболеваниях в тканях пародонта. Выявление предрасположенности и степени воспалительного процесса у пациентов, находящихся на ортодонтическом лечении, позволит реализовывать меры профилактики и лечения, улучшить наблюдение и контроль за такими пациентами.</p></abstract><trans-abstract xml:lang="en"><p>The article presents the results of the study of clinical and immunological status of 97 patients with different types of orthodontic disease before and during the orthodontic treatment. All patients underwent immunological examination which included determination of the level of antimicrobial peptide and pro-inflammatory cytokine. The study revealed that along with clinical methods it is advisable to determine the level of α-defensin and IL-1β whose function is to regulate the immunological processes during inflammation in periodontal tissues. Identifying the predisposition to inflammatory periodontal disease and degree of inflammation in patients undergoing orthodontic treatment will help to implement the measures of prevention and treatment and to improve the monitoring of the patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>заболевания пародонта</kwd><kwd>зубочелюстные аномалии</kwd><kwd>ортодонтическое лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>periodontal disease</kwd><kwd>dentoalveolar anomalies</kwd><kwd>orthodontic treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Будихина А. С., Пинегин Б. 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