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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2019-24-4-372-377</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-277</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Модуляция иммунного ответа в пародонтологии и имплантологии: потенциал противовоспалительной, антибактериальной терапии и перспективные лекарственные формы. Обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Host response modulation in periodontology and implantology: potential of anti-inflammatory, antibacterial therapy and promising dosage forms. Review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6045-3333</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantsev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующий кафедрой пародонтологии</p><p>Тверь</p></bio><bio xml:lang="en"><p>PhD, MD, professor, Hear of Department of periodontology</p><p>Tver </p></bio><email xlink:type="simple">rumyancev_v@tvergma.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5251-9424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авакова</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Avakova</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-стоматолог стоматологической поликлиники </p><p>Тверь</p></bio><bio xml:lang="en"><p>dentist of dental clinic</p><p>Tver </p></bio><email xlink:type="simple">iavakova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4315-163X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блинова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blinova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студентка 5 курса стоматологического факультета</p><p>Тверь</p></bio><bio xml:lang="en"><p>5th year student of the dental faculty</p><p>Tver </p></bio><email xlink:type="simple">blinova-alisa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тверской государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Educational «Tver State Medical University» of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>23</day><month>12</month><year>2019</year></pub-date><volume>24</volume><issue>4</issue><fpage>372</fpage><lpage>377</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Румянцев В.А., Авакова Д.Р., Блинова А.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Румянцев В.А., Авакова Д.Р., Блинова А.В.</copyright-holder><copyright-holder xml:lang="en">Rumyantsev V.A., Avakova D.R., Blinova A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/277">https://www.parodont.ru/jour/article/view/277</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>пародонтит</kwd><kwd>модуляция иммунного ответа</kwd><kwd>бисфосфонаты</kwd><kwd>антибиотики</kwd><kwd>нестероидные противовоспалительные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>periodontitis</kwd><kwd>host modulation therapy</kwd><kwd>bisphosphonates</kwd><kwd>antibiotics</kwd><kwd>non-steroidal anti-inflammatory drugs</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Румянцев В. А., Шиманский Ш. Л., Будашова Е. И. Клеточная и клиническая технологии репрограммирования макрофагов в составе комплексного лечения воспалительных заболеваний пародонта / в сборнике «Современная стоматология: от традиций к инновациям: материалы международной научно-практической конференции». 2018:328-331. https://elibrary.ru/download/elibrary_36632468_58064858.pdf.</mixed-citation><mixed-citation xml:lang="en">V. A. Rumyantsev, Sh. L. Shimanskii, E. I. Budashova. Kletochnaya i klinicheskaya tekhnologii reprogrammirovaniya makrofagov v sostave kompleksnogo lecheniya vospalitel’nykh zabolevaniy parodonta / V sbornike «Sovremennaya stomatologiya: ot traditsiy k innovatsiyam: materialy mezhdunarodnoy nauchno-prakticheskoy konferentsii». 2018:328-331. (In Russ). https://elibrary.ru/download/elibrary_36632468_58064858.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Шиманский Ш. Л., Суворова И. А., Чиликин В. Н., Малышев И. Ю., Румянцев В. А. Роль фенотипа и пластичности макрофагов в развитии воспалительной реакции при экспериментальном гингивите у мышей разных генетических линий. Dental Forum. 2015;1(56):21-24. https://elibrary.ru/download/elibrary_23062524_56311166.pdf.</mixed-citation><mixed-citation xml:lang="en">Sh. L. Shimanskii, I. A. Suvorova, V. N. Chilikin, I. Yu. Malyshev, V. A. Rumyantsev. Role of phenotype and macrophages’ plasticity in development of inflammatory reaction at experimental gingivitis in mice of different genetic lines. Dental Forum. 2015;1(56):21-24. (In Russ). https://elibrary.ru/download/elibrary_23062524_56311166.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">X. T. He, X. Li, Y.Xia et al. Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats. Acta Biomater. 2019;Feb:5. https://doi.org/10.1016/j.actbio.2019.02.004</mixed-citation><mixed-citation xml:lang="en">X. T. He, X. Li, Y.Xia et al. Building capacity for macrophage modulation and stem cell recruitment in high-stiffness hydrogels for complex periodontal regeneration: Experimental studies in vitro and in rats. Acta Biomater. 2019;Feb:5. https://doi.org/10.1016/j.actbio.2019.02.004</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">P. M. Bartold, T. E. Van Dyke. Host modulation: controlling the inflammation to control the infection. Periodontol 2000. 2017;Oct;75(1):317-329. https://doi.org/10.1111/prd.12169.</mixed-citation><mixed-citation xml:lang="en">P. M. Bartold, T. E. Van Dyke. Host modulation: controlling the inflammation to control the infection. Periodontol 2000.  2017;Oct;75(1):317-329. https://doi.org/10.1111/prd.12169.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">P. M. Preshaw. Host modulation therapy with anti-inflammatory agents. Periodontol 2000. 2018;Feb;76(1):131-149. https://doi.org/10.1111/prd.12148.</mixed-citation><mixed-citation xml:lang="en">P. M. Preshaw. Host modulation therapy with anti-inflammatory agents. Periodontol 2000. 2018;Feb;76(1):131-149. https://doi.org/10.1111/prd.12148.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">J. Slots. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;Oct;75(1):7-23. https://doi.org/10.1111/prd.12221.</mixed-citation><mixed-citation xml:lang="en">J. Slots. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;Oct;75(1):7-23. https://doi.org/10.1111/prd.12221.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">C. Heintz, W. Mair. You are what you host: microbiome modulation of the aging process. Cell. 2014;156;3:408-411. https://doi.org/10.1016/j.cell.2014.01.025.</mixed-citation><mixed-citation xml:lang="en">C. Heintz, W. Mair. You are what you host: microbiome modulation of the aging process. Cell. 2014;156;3:408-411. https://doi.org/10.1016/j.cell.2014.01.025.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">N. Donos. The periodontal pocket. Periodontol 2000. 2018;Feb;76(1):7-15. https://doi.org/10.1111/prd.12203.</mixed-citation><mixed-citation xml:lang="en">N. Donos. The periodontal pocket. Periodontol 2000. 2018;Feb;76(1):7-15. https://doi.org/10.1111/prd.12203.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">P. M. Bartold, T. E. Van Dyke An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis. J Clin Periodontol. 2019;Jan;46(1):6-11. https://doi.org/10.1111/jcpe.13046.</mixed-citation><mixed-citation xml:lang="en">P. M. Bartold, T. E. Van Dyke An appraisal of the role of specific bacteria in the initial pathogenesis of periodontitis. J Clin Periodontol. 2019;Jan;46(1):6-11. https://doi.org/10.1111/jcpe.13046.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">S. Ji, Y. S.Choi, Y. Choi. Bacterial invasion and persistence: Critical events in the pathogenesis of periodontitis? J Periodontal Res. 2015;Oct;50(5):570-85. https://doi.org/10.1111/jre.12248.</mixed-citation><mixed-citation xml:lang="en">S. Ji, Y. S.Choi, Y. Choi. Bacterial invasion and persistence: Critical events in the pathogenesis of periodontitis? J Periodontal Res. 2015;Oct;50(5):570-85. https://doi.org/10.1111/jre.12248.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">A. R. Jo, K. J. Baek, J. E. Shin, Y. Choi. Mechanisms of IL-8 suppression by Treponema denticola in gingival epithelial cells. Immunol. Cell. Biol. 2014;92;2:139-147. https://doi.org/10.1038/icb.2013.80.</mixed-citation><mixed-citation xml:lang="en">A. R. Jo, K. J. Baek, J. E. Shin, Y. Choi. Mechanisms of IL-8 suppression by Treponema denticola in gingival epithelial cells. Immunol. Cell. Biol. 2014;92;2:139-147. https://doi.org/10.1038/icb.2013.80.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">R. P. Settem, K. Honma, G. P. Stafford, A. Sharma. Protein-linked glycans in periodontal bacteria: prevalence and role at the immune interface. Front. Microbiol. 2013;17;4:310. https://doi.org/10.3389/fmicb.2013.00310.</mixed-citation><mixed-citation xml:lang="en">R. P. Settem, K. Honma, G. P. Stafford, A. Sharma. Protein-linked glycans in periodontal bacteria: prevalence and role at the immune interface. Front. Microbiol. 2013;17;4:310. https://doi.org/10.3389/fmicb.2013.00310.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">A. Plessas. Nonsurgical periodontal treatment: review of the evidence. Oral Health Dent. Manag. 2014;13;1:71-80. PubMed PMID: 24603920. https://www.ncbi.nlm.nih.gov/pubmed/24603920.</mixed-citation><mixed-citation xml:lang="en">A. Plessas. Nonsurgical periodontal treatment: review of the evidence. Oral Health Dent. Manag. 2014;13;1:71-80. PubMed PMID: 24603920. https://www.ncbi.nlm.nih.gov/pubmed/24603920.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Шинкаренко Т. В., Румянцев В. А., Егорова Е. Н., Елисеева Т. И. Матриксные металлопротеиназы при заболеваниях пародонта (Обзор литературы). Стоматология. 2013;2:77-80. Режим доступа: https://elibrary.ru/item.asp?id=19034130.</mixed-citation><mixed-citation xml:lang="en">T. V. Shinkarenko, V. A. Rumyantsev, E. N. Egorova, T. I. Eliseeva. Matrix metalloproteinases in periodontitis. Stomatologiya. 2013;2:77-80. (In Russ)]. https://elibrary.ru/item.asp?id=19034130.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Шиманский Ш. Л., Чиликин В. Н., Малышев И. Ю., Суворова И. А., Румянцев В. А., Денис А. Г. Фагоцитарная защита пародонта и способы ее активации (обзор литературы). Стоматология. 2013;5:60-65. https://elibrary.ru/item.asp?id=21084672.</mixed-citation><mixed-citation xml:lang="en">Sh. L. Shimanskii, V. N. Chilikin, I. Yu. Malyshev, I. A. Suvorova, V. A. Rumyantsev, Denis A.G.  Phagocytes protection of periodontium and its ways activation.  Stomatologiya. 2013;5:60-65. (In Russ)]. https://elibrary.ru/item.asp?id=21084672.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">P. Kumar, L. Kumar, S. Murthy, Gurudath G. Matrix metalloprotienases and its inhibitors: an insight. J. Int. Oral. Health. 2014;6;1:127-129. PubMed PMID: 24653617. https://www.ncbi.nlm.nih.gov/pubmed/24653617.</mixed-citation><mixed-citation xml:lang="en">P. Kumar, L. Kumar, S. Murthy, Gurudath G. Matrix metalloprotienases and its inhibitors: an insight. J. Int. Oral. Health. 2014;6;1:127-129. PubMed PMID: 24653617. https://www.ncbi.nlm.nih.gov/pubmed/24653617.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">P. Dash, B. Kar, A. Mishra, P. K. Sahoo. Effect of Dactylogyrus catlaius (Jain 1961) infection in Labeo rohita (Hamilton 1822): innate immune responses and expression profile of some immune related genes. Indian J. Exp. Biol. 2014;52;3:267-280. PubMed PMID: 24669670. https://www.ncbi.nlm.nih.gov/pubmed/24669670э</mixed-citation><mixed-citation xml:lang="en">P. Dash, B. Kar, A. Mishra, P. K. Sahoo. Effect of Dactylogyrus catlaius (Jain 1961) infection in Labeo rohita (Hamilton 1822): innate immune responses and expression profile of some immune related genes. Indian J. Exp. Biol. 2014;52;3:267-280. PubMed PMID: 24669670. https://www.ncbi.nlm.nih.gov/pubmed/24669670э</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">G. Conti, M. C. Rodriguez, A. L. Venturuzzi, S. Asurmendi. Modulation of host plant immunity by Tobamovirus proteins. Ann Bot. 2017;Mar1;119(5):737-747. https://doi.org/10.1093/aob/mcw216.</mixed-citation><mixed-citation xml:lang="en">G. Conti, M. C. Rodriguez, A. L. Venturuzzi, S. Asurmendi. Modulation of host plant immunity by Tobamovirus proteins. Ann Bot. 2017;Mar1;119(5):737-747. https://doi.org/10.1093/aob/mcw216.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">A. L. Hilchie, K. Wuerth, R. E. Hancock. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat. Chem. Biol. 2013;9;12:761-768. https://doi.org/10.1038/nchembio.1393.</mixed-citation><mixed-citation xml:lang="en">A. L. Hilchie, K. Wuerth, R. E. Hancock. Immune modulation by multifaceted cationic host defense (antimicrobial) peptides. Nat. Chem. Biol. 2013;9;12:761-768. https://doi.org/10.1038/nchembio.1393.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gokhale S.R., Padhye A.M. Future prospects of systemic host modulatory agents in periodontal therapy / Br. Dent. J., 2013, Vol. 214, № 9, Р. 467 – 471. https://doi.org/10.1038/sj.bdj.2013.432</mixed-citation><mixed-citation xml:lang="en">Gokhale S.R., Padhye A.M. Future prospects of systemic host modulatory agents in periodontal therapy / Br. Dent. J., 2013, Vol. 214, № 9, Р. 467 – 471. https://doi.org/10.1038/sj.bdj.2013.432</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Üstün K., Erciyas K., Kısacık B. et al. Host modulation in rheumatoid arthritis patients with TNF blockers significantly decreases biochemical parameters in periodontitis / Inflammation, 2013, Vol. 36, № 5, P. 1171 – 1177. https://doi.org/10.1007/s10753-013-9652-9</mixed-citation><mixed-citation xml:lang="en">Üstün K., Erciyas K., Kısacık B. et al. Host modulation in rheumatoid arthritis patients with TNF blockers significantly decreases biochemical parameters in periodontitis / Inflammation, 2013, Vol. 36, № 5, P. 1171 – 1177. https://doi.org/10.1007/s10753-013-9652-9</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Зубцов В. А., Румянцев В. А. Влияние избытка сахарозы и сахарозаменителей на регенерацию и остеоиндуктивную активность нижнечелюстной кости. Институт стоматологии. 2011;1(50):116-117. Режим доступа: https://elibrary.ru/download/elibrary_16553506_86637551.pdf.</mixed-citation><mixed-citation xml:lang="en">V. A. Zubtsov, V. A. Rumyantsev. Vliyanie izbytka sakharozy i sakharozameniteley na regeneratsiyu i osteoinduktivnuyu aktivnost’ nizhnechelyustnoy kosti. Institut stomatologii. 2011;1(50):116–117. (In Russ). https://elibrary.ru/download/elibrary_16553506_86637551.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">J. Uyanne, C. C. Calhoun, A. D. Le. Antiresorptive drug-related osteonecrosis of the jaw. Dent. Clin. North. Am. 2014;2:369-384. https://doi.org/10.1016/j.cden.2013.12.006</mixed-citation><mixed-citation xml:lang="en">J. Uyanne, C. C. Calhoun, A. D. Le. Antiresorptive drug-related osteonecrosis of the jaw. Dent. Clin. North. Am. 2014;2:369-384. https://doi.org/10.1016/j.cden.2013.12.006</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Y. H. Hwang, T. Kim, R. Kim, H. Ha. The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E₂ Levels. Int J Mol Sci. 2018;Jul;16;19(7). https://doi.org/10.3390/ijms19072068.</mixed-citation><mixed-citation xml:lang="en">Y. H. Hwang, T. Kim, R. Kim, H. Ha. The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E₂ Levels. Int J Mol Sci. 2018;Jul;16;19(7). https://doi.org/10.3390/ijms19072068.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">P. Gümüş, N. Nizam, A. Nalbantsoy et al. Saliva, Serum Levels of Interleukin-21, -33 and Prostaglandin E2 in Patients with Generalised Aggressive or Chronic Periodontitis. Oral Health Prev Dent. 2017;15(4):385-390. https://doi.org/10.3290/j.ohpd.a38740.</mixed-citation><mixed-citation xml:lang="en">P. Gümüş, N. Nizam, A. Nalbantsoy et al. Saliva, Serum Levels of Interleukin-21, -33 and Prostaglandin E2 in Patients with Generalised Aggressive or Chronic Periodontitis. Oral Health Prev Dent. 2017;15(4):385-390. https://doi.org/10.3290/j.ohpd.a38740.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">S. J. Shin, C. K. Noh, S. G. Lim et al. Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res. 2017;Oct;15(4):446-455. https://doi.org/10.5946/ce.2012.45.2.138.</mixed-citation><mixed-citation xml:lang="en">S. J. Shin, C. K. Noh, S. G. Lim et al. Non-steroidal anti-inflammatory drug-induced enteropathy. Intest Res. 2017;Oct;15(4):446-455. https://doi.org/10.5946/ce.2012.45.2.138.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">J. D. Luo, C. Miller, D. Sharma. Effect of Nonsteroidal Anti-inflammatory Drugs on the Osteogenic Activity of Osteoprogenitor Cells Cultured on Titanium Surfaces. Int J Oral Maxillofac Implants. 2019;Feb:19. https://doi.org/10.11607/jomi.7289.</mixed-citation><mixed-citation xml:lang="en">J. D. Luo, C. Miller, D. Sharma. Effect of Nonsteroidal Anti-inflammatory Drugs on the Osteogenic Activity of Osteoprogenitor Cells Cultured on Titanium Surfaces. Int J Oral Maxillofac Implants. 2019;Feb:19. https://doi.org/10.11607/jomi.7289.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">D. Tindle, C. A. Murdoch-Kinch. Dental management of patients taking oral bisphosphonates and other antiresorptive agents. J. Mich. Dent. Assoc. 2013;95;8:40-42. PubMed PMID: 24159705. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/24159705.</mixed-citation><mixed-citation xml:lang="en">D. Tindle, C. A. Murdoch-Kinch. Dental management of patients taking oral bisphosphonates and other antiresorptive agents. J. Mich. Dent. Assoc. 2013;95;8:40-42. PubMed PMID: 24159705. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/24159705.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">F. Paiva-Fonseca, A. R. Santos-Silva, R. Della-Coletta, P. A. Vargas, M. A. Lopes. Alendronate-associated osteonecrosis of the jaws: A review of the main topics. Med. Oral Patol. Oral Ci.r Bucal. 2014;19:2. https://doi.org/e106 – 111. 10.4317/medoral.19094.</mixed-citation><mixed-citation xml:lang="en">F. Paiva-Fonseca, A. R. Santos-Silva, R. Della-Coletta, P. A. Vargas, M. A. Lopes. Alendronate-associated osteonecrosis of the jaws: A review of the main topics. Med. Oral Patol. Oral Ci.r Bucal. 2014;19:2. https://doi.org/e106 – 111. 10.4317/medoral.19094.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">D. K. Wysowski, P. Greene. Trends in osteoporosis treatment with oral and intravenous bisphosphonates in the United States, 2002-2012. Bone. 2013;57;2:423-428. https://doi.org/10.1016/j.bone.2013.09.008.</mixed-citation><mixed-citation xml:lang="en">D. K. Wysowski, P. Greene. Trends in osteoporosis treatment with oral and intravenous bisphosphonates in the United States, 2002-2012. Bone. 2013;57;2:423-428. https://doi.org/10.1016/j.bone.2013.09.008.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">K. N. Hogan, J. L. Milchak, R. M. Heilmann, S. J. Billups, T. Delate. Evaluation of primary nonadherence to oral bisphosphonate therapy. J. Am. Geriatr. Soc. 2013;61;11:2046-2047. https://doi.org/10.1111/jgs.12521.</mixed-citation><mixed-citation xml:lang="en">K. N. Hogan, J. L. Milchak, R. M. Heilmann, S. J. Billups, T. Delate. Evaluation of primary nonadherence to oral bisphosphonate therapy. J. Am. Geriatr. Soc. 2013;61;11:2046-2047. https://doi.org/10.1111/jgs.12521.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">A. T. Moinzadeh, N. A. M. Neirynck, H. Shemesh, Aubert, P. R. Wesselink. Bisphosphonates and their clinical implications in endodontic therapy. Int. Endodont. J. 2013;46;5:391-398. https://doi.org/10.1111/iej.12018.</mixed-citation><mixed-citation xml:lang="en">A. T. Moinzadeh, N. A. M. Neirynck, H. Shemesh, Aubert, P. R. Wesselink. Bisphosphonates and their clinical implications in endodontic therapy. Int. Endodont. J. 2013;46;5:391-398.  https://doi.org/10.1111/iej.12018.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">S. Gupta, H. Gupta, D. Mandhyan, S. Srivastava. Bisphophonates related osteonecrosis of the jaw. Natl. J. Maxillofac. Surg. 2013;4;2:151-158. https://doi.org/10.4103/0975-5950.127643.</mixed-citation><mixed-citation xml:lang="en">S. Gupta, H. Gupta, D. Mandhyan, S. Srivastava. Bisphophonates related osteonecrosis of the jaw. Natl. J. Maxillofac. Surg. 2013;4;2:151-158. https://doi.org/10.4103/0975-5950.127643.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">M. Moeini, M. Moeini, N. Lotfizadeh, M. Alavi. Radiography finding in the jaws in children taking bisphosphonate. Iran J. Ped. Hematol. Oncol. 2013;3;3:114-118. PubMed PMID: 24575282. https://www.ncbi.nlm.nih.gov/pubmed/24575282.</mixed-citation><mixed-citation xml:lang="en">M. Moeini, M. Moeini, N. Lotfizadeh, M. Alavi. Radiography finding in the jaws in children taking bisphosphonate. Iran J. Ped. Hematol. Oncol. 2013;3;3:114-118. PubMed PMID: 24575282. https://www.ncbi.nlm.nih.gov/pubmed/24575282.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Спевак Е. М., Цымбал А. Н. Бифосфонатные остеонекрозы челюстей. Современное состояние проблемы. Казанский медицинский журнал. 2017;98;1:91-95. https://cyberleninka.ru/article/n/bisfosfonatnye-osteonekrozy-chelyustey-sovremennoe-sostoyanie-problemy/viewer.</mixed-citation><mixed-citation xml:lang="en">E. M. Spevak, A. N. Tsymbal. Bisphosphonate-related osteonecrosis of the jaw: current state of the problem / Kazanskiy meditsinskiy zhurnal. 2017;98;1:91-95. (In Russ). https://cyberleninka.ru/article/n/bisfosfonatnye-osteonekrozy-chelyustey-sovremennoe-sostoyanie-problemy/viewer.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">G. Campisi, S. Fedele, V. Fusco, G. Pizzo, Fede Di O. Bedogni A. Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents. Future Oncol. 2014;10;2: 257-275. https://doi.org/10.2217/fon.13.211.</mixed-citation><mixed-citation xml:lang="en">G. Campisi, S. Fedele, V. Fusco, G. Pizzo, Fede Di O. Bedogni A. Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents. Future Oncol. 2014;10;2: 257-275. https://doi.org/10.2217/fon.13.211.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">J. K. Lee, K. W. Kim, J. Y. Choi, S. Y. Moon, S. G. Kim et al. Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report. J. Korean. Assoc. Oral. Maxillofac. Surg. 2013;39;1:9-13. https://doi.org/10.5125/jkaoms.2013.39.1.9</mixed-citation><mixed-citation xml:lang="en">J. K. Lee, K. W. Kim, J. Y. Choi, S. Y. Moon, S. G. Kim et al. Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report. J. Korean. Assoc. Oral. Maxillofac. Surg. 2013;39;1:9-13. https://doi.org/10.5125/jkaoms.2013.39.1.9</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">C. J. Smiley, S. L. Tracy, E. Abt et al. Evidence‐based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146:525-535. https://doi.org/10.1016/j.adaj.2015.01.026.</mixed-citation><mixed-citation xml:lang="en">C. J. Smiley, S. L. Tracy, E. Abt et al. Evidence‐based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146:525-535. https://doi.org/10.1016/j.adaj.2015.01.026.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">G. K. Chadha, A. Ahmadieh, S. Kumar, P. P. Sedghizadeh. Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review. J. Oral Implantol. 2013;39;4:510-520. https://doi.org/10.1563/AAID-JOI-D-11-00234.</mixed-citation><mixed-citation xml:lang="en">G. K. Chadha, A. Ahmadieh, S. Kumar, P. P. Sedghizadeh. Osseointegration of dental implants and osteonecrosis of the jaw in patients treated with bisphosphonate therapy: a systematic review. J. Oral Implantol. 2013;39;4:510-520. https://doi.org/10.1563/AAID-JOI-D-11-00234.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">J. L. López-Cedrún, J. F. Sanromán, A. García et al. Oral bisphosphonate-related osteonecrosis of the jaws in dental implant patients: a case series. Br. J. Oral Maxillofac. Surg. 2013;8:874-879. https://doi.org/10.1016/j.bjoms.2013.06.011.</mixed-citation><mixed-citation xml:lang="en">J. L. López-Cedrún, J. F. Sanromán, A. García et al. Oral bisphosphonate-related osteonecrosis of the jaws in dental implant patients: a case series. Br. J. Oral Maxillofac. Surg. 2013;8:874-879. https://doi.org/10.1016/j.bjoms.2013.06.011.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">F. Zuffetti, T. Testori, M. Capelli, M. C. Rossi, M. Del Fabbro. The topical administration of bisphosphonates in implant surgery: a randomized split-mouthprospective study with a follow-up up to 5 years. Clin. Implant. Dent. Relat. Res. 2013;20:152-156. https://doi.org/10.1111/cid.12151.</mixed-citation><mixed-citation xml:lang="en">F. Zuffetti, T. Testori, M. Capelli, M. C. Rossi, M. Del Fabbro. The topical administration of bisphosphonates in implant surgery: a randomized split-mouthprospective study with a follow-up up to 5 years. Clin. Implant. Dent. Relat. Res. 2013;20:152-156. https://doi.org/10.1111/cid.12151.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">I. Kim, H. Ki, W. Lee, H. Kim, J. B. Park. The effect of systemically administered bisphosphonates on bony healing after tooth extraction and osseointegration of dental implants in the rabbit maxilla. Int. J. Ora.l Maxillofac. Implants. 2013;28;5:1194-1200. https://doi.org/10.11607/jomi.2685.</mixed-citation><mixed-citation xml:lang="en">I. Kim, H. Ki, W. Lee, H. Kim, J. B. Park. The effect of systemically administered bisphosphonates on bony healing after tooth extraction and osseointegration of dental implants in the rabbit maxilla. Int. J. Ora.l Maxillofac. Implants. 2013;28;5:1194-1200. https://doi.org/10.11607/jomi.2685.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">J. A. Vermeer, I. D. Jansen, M. Marthi et al. Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors. Bone. 2013;57;1:242-251. https://doi.org/10.1016/j.bone.2013.08.007.</mixed-citation><mixed-citation xml:lang="en">J. A. Vermeer, I. D. Jansen, M. Marthi et al. Jaw bone marrow-derived osteoclast precursors internalize more bisphosphonate than long-bone marrow precursors. Bone. 2013;57;1:242-251. https://doi.org/10.1016/j.bone.2013.08.007.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">L. Longato, L. Cavalli, G. Marcucci et al. Osteonecrosis of the jaw in a patient with rheumatoid artritis treated with an oralaminobisphosphonate: a clinical case report. Clin. Cases Miner. Bone Metab. 2013;10;2:139-141. PubMed PMID: 24133533. https://www.ncbi.nlm.nih.gov/pubmed/24133533.</mixed-citation><mixed-citation xml:lang="en">L. Longato, L. Cavalli, G. Marcucci et al. Osteonecrosis of the</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">M. Ulmner, F. Jarnbring, O. Törring. Osteonecrosis of the jaw in Sweden associated with the oral use of bisphosphonate. J. Oral. Maxillofac.Surg. 2014;72;1:76-82. https://doi.org/10.1016/j.joms.2013.06.221.</mixed-citation><mixed-citation xml:lang="en">jaw in a patient with rheumatoid artritis treated with an  oralaminobisphosphonate: a clinical case report. Clin. Cases Miner. Bone Metab. 2013;10;2:139-141. PubMed PMID: 24133533. https://www.ncbi.nlm.nih.gov/pubmed/24133533.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">C. Le Henaff, F. Velard, J. Jacquot. Bone health in cystic fibrosis: use of oral bisphosphonates. Lancet Respir. Med. 2013;1;5:349-350. https://doi.org/10.1016/S2213-2600(13)70096-1.</mixed-citation><mixed-citation xml:lang="en">M. Ulmner, F. Jarnbring, O. Törring. Osteonecrosis of the jaw in Sweden associated with the oral use of bisphosphonate. J. Oral. Maxillofac.Surg. 2014;72;1:76-82. https://doi.org/10.1016/j.joms.2013.06.221.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">T. Badel, I. S. Pavicin, A. J. Carek, K. Rosin-Grget, D. Grbesa. Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate. Coll. Antropol. 2013;37;2:645-651. PubMed PMID: 23941019. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/23941019.</mixed-citation><mixed-citation xml:lang="en">C. Le Henaff, F. Velard, J. Jacquot. Bone health in cystic fibrosis: use of oral bisphosphonates. Lancet Respir. Med. 2013;1;5:349-350. https://doi.org/10.1016/S2213-2600(13)70096-1.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">S. E. Pichardo, J. P. van Merkesteyn. Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin? Oral Surg. 2013;116;3:287-292. https://doi.org/10.1016/j.oooo.2013.05.005.</mixed-citation><mixed-citation xml:lang="en">T. Badel, I. S. Pavicin, A. J. Carek, K. Rosin-Grget, D. Grbesa. Pathophysiology of osteonecrosis of the jaw in patients treated with bisphosphonate. Coll. Antropol. 2013;37;2:645-651. PubMed PMID: 23941019. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/23941019.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">S. Otto, C. Pautke, S. Hafner et al. Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases / Craniomaxillofac. Trauma Reconstr. 2013;6;3:147-154. https://doi.org/10.1055/s-0033-1343776.</mixed-citation><mixed-citation xml:lang="en">S. E. Pichardo, J. P. van Merkesteyn. Bisphosphonate related osteonecrosis of the jaws: spontaneous or dental origin? Oral Surg. 2013;116;3:287-292. https://doi.org/10.1016/j.oooo.2013.05.005.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">M. U. Zaman, T. Nakamoto, K. Tanimoto. A retrospective study of digital subtraction technique to detect sclerotic changes in alveolar bone on intraoral radiographs of bisphosphonate-treated patients. Dentomaxillofac Radiоl. 2013;42;10:242. https://doi.org/10.1259/dmfr.20130242.</mixed-citation><mixed-citation xml:lang="en">S. Otto, C. Pautke, S. Hafner et al. Pathologic fractures in bisphosphonate-related osteonecrosis of the jaw-review of the literature and review of our own cases / Craniomaxillofac. Trauma Reconstr. 2013;6;3:147-154. https://doi.org/10.1055/s-0033-1343776.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">J. W. Kim, K. A. Kong, S. J. Kim, S. K. Choi, I. H. Cha, M. R. Kim. Prospective biomarker evaluation in patients with osteonecrosis of the jaw who received bisphosphonates. Bone. 2013;57;1:201-205. https://doi.org/10.1016/j.bone.2013.08.005.</mixed-citation><mixed-citation xml:lang="en">M. U. Zaman, T. Nakamoto, K. Tanimoto. A retrospective study of digital subtraction technique to detect sclerotic changes in alveolar bone on intraoral radiographs of bisphosphonate-treated patients. Dentomaxillofac Radiоl. 2013;42;10:242. https://doi.org/10.1259/dmfr.20130242.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">R. Bhatt, S. Hibbert, C. Munns. The use of bisphosphonates in children: review of the literature and guidelines for dental management. Aust. Dent. J. 2014;59;1:9-19. https://doi.org/10.1111/adj.12140.</mixed-citation><mixed-citation xml:lang="en">J. W. Kim, K. A. Kong, S. J. Kim, S. K. Choi, I. H. Cha, M. R. Kim. Prospective biomarker evaluation in patients with osteonecrosis of the jaw who received bisphosphonates. Bone. 2013;57;1:201-205. https://doi.org/10.1016/j.bone.2013.08.005.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">J. Christou, A. R. Johnson, T. A. Hodgson. Bisphosphonate-related osteonecrosis of the jaws and its relevance to children-a review. Int. J. Paediatr. Dent. 2013;23;5:330-337. https://doi.org/10.1111/ipd.12047.</mixed-citation><mixed-citation xml:lang="en">R. Bhatt, S. Hibbert, C. Munns. The use of bisphosphonates in children: review of the literature and guidelines for dental management. Aust. Dent. J. 2014;59;1:9-19. https://doi.org/10.1111/adj.12140.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">K. K. Ngan, J. Bowe, N. Goodger. The risk of bisphosphonate-related osteonecrosis of the jaw in children. A case report and literature review. Dent. Update. 2013;40;9:733-734. https://doi.org/10.12968/denu.2013.40.9.733.</mixed-citation><mixed-citation xml:lang="en">J. Christou, A. R. Johnson, T. A. Hodgson. Bisphosphonate-related osteonecrosis of the jaws and its relevance to children-a review. Int. J. Paediatr. Dent. 2013;23;5:330-337.  https://doi.org/10.1111/ipd.12047.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">M. R. Allen, S. L. Ruggiero. A review of pharmaceutical agents and oral bone health: how osteonecrosis of the jaw has affected the field. Int. J. Oral Maxillofac. Implants. 2014;29;1:e45-57. https://doi.org/10.11607/jomi.te41.</mixed-citation><mixed-citation xml:lang="en">K. K. Ngan, J. Bowe, N. Goodger. The risk of bisphosphonate-related osteonecrosis of the jaw in children. A case report and literature review. Dent. Update. 2013;40;9:733-734. https://doi.org/10.12968/denu.2013.40.9.733.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">H. S. Grover, S. Luthra, S. Maroo. Teriparatide: a novel means to ultimately achieve true regeneration! J. Clin. Diagn. Res. 2013;7;8:1820-1823. https://doi.org/10.7860/JCDR/2013/5893.3280.</mixed-citation><mixed-citation xml:lang="en">M. R. Allen, S. L. Ruggiero. A review of pharmaceutical agents and oral bone health: how osteonecrosis of the jaw has affected the field. Int. J. Oral Maxillofac. Implants. 2014;29;1:e45-57. https://doi.org/10.11607/jomi.te41.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">M. Pazianas, B. Abrahamsen, S. Ferrari, R. G. Russell. Eliminating the need for fasting with oral administration of bisphosphonates. Ther. Clin. Risk. Manag. 2013;9:395-402. https://doi.org/10.2147/TCRM.S52291.</mixed-citation><mixed-citation xml:lang="en">H. S. Grover, S. Luthra, S. Maroo. Teriparatide: a novel means to ultimately achieve true regeneration! J. Clin. Diagn. Res. 2013;7;8:1820-1823. https://doi.org/10.7860/JCDR/2013/5893.3280.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">A. A. Alyousef, D. D. Divakar, Muzaheed. Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: A randomized, double-blind, placebo-controlled, clinical trial. Microb Pathog. 2017;Sep;110:279-284. https://doi.org/10.1016/j.micpath.2017.07.002.</mixed-citation><mixed-citation xml:lang="en">M. Pazianas, B. Abrahamsen, S. Ferrari, R. G. Russell. Eliminating the need for fasting with oral administration of bisphosphonates. Ther. Clin. Risk. Manag. 2013;9:395-402. https://doi.org/10.2147/TCRM.S52291.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">D. N. Swamy, S. Sanivarapu, S. Moogla, V. Kapalavai. Chemically modified tetracyclines: The novel host modulating agents. J Indian Soc Periodontol. 2015;Jul-Aug;19(4):370-4. https://doi.org/10.4103/0972-124X.149934.</mixed-citation><mixed-citation xml:lang="en">A. A. Alyousef, D. D. Divakar, Muzaheed. Chemically modified tetracyclines an emerging host modulator in chronic periodontitis patients: A randomized, double-blind, placebo-controlled, clinical trial. Microb Pathog. 2017;Sep;110:279-284.  https://doi.org/10.1016/j.micpath.2017.07.002.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">T. Sorsa, U. Gursoy, S. Nwhator et al. Analysis of matrix metalloproteinases in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70:142-163. https://doi.org/10.1111/prd.12101.</mixed-citation><mixed-citation xml:lang="en">D. N. Swamy, S. Sanivarapu, S. Moogla, V. Kapalavai. Chemically modified tetracyclines: The novel host modulating agents. J Indian Soc Periodontol. 2015;Jul-Aug;19(4):370-4. https://doi.org/10.4103/0972-124X.149934.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">S. Memmert, M. Nokhbehsaim, A. Damanaki et. al. Role of cathepsin S In periodontal wound healing–an in vitro study on human PDL cells. BMC Oral Health. 2018;Apr;5;18(1):60. https://doi.org/10.1186/s12903-018-0518-2.</mixed-citation><mixed-citation xml:lang="en">T. Sorsa, U. Gursoy, S. Nwhator et al. Analysis of matrix metalloproteinases in gingival crevicular fluid, mouthrinse and saliva for monitoring periodontal diseases. Periodontol 2000. 2016;70:142-163. https://doi.org/10.1111/prd.12101.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">C. J. Smiley, S. L. Tracy, E. Abt et al. Evidence‐based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146:525-535. https://doi.org/10.1016/j.adaj.2015.01.026.</mixed-citation><mixed-citation xml:lang="en">S. Memmert, M. Nokhbehsaim, A. Damanaki et. al. Role of cathepsin S In periodontal wound healing–an in vitro study on human PDL cells. BMC Oral Health. 2018;Apr;5;18(1):60. https://doi.org/10.1186/s12903-018-0518-2.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">L. M. Golub, M. S. Elburki, C. Walker et al. Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases. Int Dent J. 2016;Jun;66(3):127-35. https://doi.org/10.1111/idj.12221.</mixed-citation><mixed-citation xml:lang="en">C. J. Smiley, S. L. Tracy, E. Abt et al. Evidence‐based clinical practice guideline on the nonsurgical treatment of chronic periodontitis by means of scaling and root planing with or without adjuncts. J Am Dent Assoc. 2015;146:525-535. https://doi.org/10.1016/j.adaj.2015.01.026.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">A. Yağan, S. Kesim, N. Liman. Effect of low‐dose doxycycline on serum oxidative status, gingival antioxidant levels, and alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2014,85:478-489. https://doi.org/10.1902/jop.2013.130138.</mixed-citation><mixed-citation xml:lang="en">L. M. Golub, M. S. Elburki, C. Walker et al. Non-antibacterial tetracycline formulations: host-modulators in the treatment of periodontitis and relevant systemic diseases. Int Dent J. 2016;Jun;66(3):127-35. https://doi.org/10.1111/idj.12221.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">A. A. Ghangurde, K. K. Ganji, M. L. Bhongade, B. Sehdev. Role of Chemically Modified Tetracyclines in the Management of Periodontal Diseases: A Review. Drug Res (Stuttg). 2017;May;67(5):258-265. https://doi.org/10.1055/s-0043-100633.</mixed-citation><mixed-citation xml:lang="en">A. Yağan, S. Kesim, N. Liman. Effect of low‐dose doxycycline on serum oxidative status, gingival antioxidant levels, and alveolar bone loss in experimental periodontitis in rats. J Periodontol. 2014,85:478-489. https://doi.org/10.1902/jop.2013.130138.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">K. Kaur, P. Sikri. Evaluation of the effect of allograft with doxycycline versus the allograft alone in the treatment of infrabony defects: A controlled clinical and radiographical study. Dent. Res. J. (Isfahan). 2013;10;2:238-246. PubMed PMID: 23946743. https://www.ncbi.nlm.nih.gov/pubmed/23946743.</mixed-citation><mixed-citation xml:lang="en">A. A. Ghangurde, K. K. Ganji, M. L. Bhongade, B. Sehdev. Role of Chemically Modified Tetracyclines in the Management of  Periodontal Diseases: A Review. Drug Res (Stuttg). 2017;May;67(5):258-265. https://doi.org/10.1055/s-0043-100633.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">T. H. Grossman. Tetracycline Antibiotics and Resistance. Cold Spring Harb Perspect Med. 2016:Apr. https://doi.org/10.1101/cshperspect.a025387.</mixed-citation><mixed-citation xml:lang="en">K. Kaur, P. Sikri. Evaluation of the effect of allograft with doxycycline versus the allograft alone in the treatment of infrabony defects: A controlled clinical and radiographical study. Dent. Res. J. (Isfahan). 2013;10;2:238-246. PubMed PMID: 23946743. https://www.ncbi.nlm.nih.gov/pubmed/23946743.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">M. S. Shinwari, F. Tanwir, P. R. Hyder, M. H. Bin Saeed Host modulation therapeutics in periodontics: role as an adjunctive periodontal therapy. J Coll Physicians Surg Pak. 2014;Sep;24(9):676-84. PubMed PMID: 25233975. https://www.ncbi.nlm.nih.gov/pubmed/25233975.</mixed-citation><mixed-citation xml:lang="en">T. H. Grossman. Tetracycline Antibiotics and Resistance. Cold Spring Harb Perspect Med. 2016:Apr. https://doi.org/10.1101/cshperspect.a025387.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">S. Shetty, A. Bose, S. Sridharan, A. Satyanarayana, A. Rahul. A clinicobiochemical evaluation of the role of an herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study. Oral Health Dent. Manag. 2013;12;2:95-104. PubMed PMID: 23756425. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/23756425.</mixed-citation><mixed-citation xml:lang="en">M. S. Shinwari, F. Tanwir, P. R. Hyder, M. H. Bin Saeed Host modulation therapeutics in periodontics: role as an adjunctive periodontal therapy. J Coll Physicians Surg Pak. 2014;Sep;24(9):676-84. PubMed PMID: 25233975. https://www.ncbi.nlm.nih.gov/pubmed/25233975.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">H. S. Grover, S. Luthra, S. Maroo, N. Maroo. The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? Dent. Res. J. (Isfahan). 2013;10;2:143-148. PubMed PMID: 23946727. https://www.ncbi.nlm.nih.gov/pubmed/23946727.</mixed-citation><mixed-citation xml:lang="en">S. Shetty, A. Bose, S. Sridharan, A. Satyanarayana, A. Rahul. A clinicobiochemical evaluation of the role of an herbal (Ayurvedic) immunomodulator in chronic periodontal disease: a pilot study. Oral Health Dent. Manag. 2013;12;2:95-104. PubMed PMID: 23756425. Режим доступа: https://www.ncbi.nlm.nih.gov/pubmed/23756425.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">H. S. Grover, S. Luthra, S. Maroo, N. Maroo. The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? Dent. Res. J. (Isfahan). 2013;10;2:143-148. PubMed PMID: 23946727. https://www.ncbi.nlm.nih.gov/pubmed/23946727.</mixed-citation><mixed-citation xml:lang="en">H. S. Grover, S. Luthra, S. Maroo, N. Maroo. The pleotropic role of statins: Could it be the imminent host modulation agent in periodontics? Dent. Res. J. (Isfahan). 2013;10;2:143-148. PubMed PMID: 23946727. https://www.ncbi.nlm.nih.gov/pubmed/23946727.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
