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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2021-26-1-52-57</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-429</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Состояние пародонтального, глоссального и иммунного статусов у мужчин с синдромом зависимости от алкоголя</article-title><trans-title-group xml:lang="en"><trans-title>Condition of the tongue, periodontal and immune statuses in men with alcohol dependence syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3537-5817</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кунавина</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kunavina</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кунавина Карина Александровна, к.м.н., доцент кафедры терапевтической стоматологии </p><p>Архангельск</p></bio><bio xml:lang="en"><p>Kunavina, Karina A., PhD, Associate professor of Department of Restorative Dentistry </p><p>Arkhangelsk</p></bio><email xlink:type="simple">kunavina.karina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0057-3357</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оправин</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Opravin</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оправин Александр Сергеевич, д.м.н., профессор, заведующий кафедрой терапевтической стоматологии</p><p>Архангельск</p></bio><bio xml:lang="en"><p>Opravin, Aleksandr S., PhD, MD, DSc, Professor, Head of Department of Restorative Dentistry </p><p>Arkhangelsk</p></bio><email xlink:type="simple">opravinas@nsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0350-1359</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьев</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Soloviev</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьев Андрей Горгоньевич, д.м.н., профессор, заведующий кафедрой психиатрии и клинической психологии </p><p>Архангельск</p></bio><bio xml:lang="en"><p>Kharkova, Olga A., phD, Associate Professor of Department of Pedagogics and Psychology </p><p>Arkhangelsk</p></bio><email xlink:type="simple">asoloviev1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3130-2920</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харькова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Harkova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харькова Ольга Александровна, к.м.н., доцент кафедры педагогики и психологии</p><p>Архангельск</p></bio><bio xml:lang="en"><p>Soloviev, Andrey G., PhD, MD, DSc, Professor, Head of Department of Psychiatry and Clinical Psychology </p><p> Arkhangelsk</p></bio><email xlink:type="simple">harkovaolga@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6414-9870</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давидович</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Davidovich</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давидович Наталия Валерьевна, к.м.н., доцент кафедры клинической биохимии, микробиологии и лабораторной диагностики </p><p>Архангельск</p></bio><bio xml:lang="en"><p>Davidovich, Nataliia V., PhD, Associate professor of Department of Clinical Biochemistry, Microbiology and Laboratory Diagnostics </p><p>Arkhangelsk</p></bio><email xlink:type="simple">nvdavidovich@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северный государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Northern State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>05</day><month>03</month><year>2021</year></pub-date><volume>26</volume><issue>1</issue><fpage>52</fpage><lpage>57</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кунавина К.А., Оправин А.С., Соловьев А.Г., Харькова О.А., Давидович Н.В., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Кунавина К.А., Оправин А.С., Соловьев А.Г., Харькова О.А., Давидович Н.В.</copyright-holder><copyright-holder xml:lang="en">Kunavina K.A., Opravin A.S., Soloviev A.G., Harkova O.A., Davidovich N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/429">https://www.parodont.ru/jour/article/view/429</self-uri><abstract><p>Актуальность. Стоматологические проблемы, среди которых существенную долю занимают заболевания пародонта, часто выявляются у лиц с синдромом зависимости от алкоголя (СЗА). Перспективным представляется изучение совокупности показателей пародонтального, глоссального и иммунного статусов у больных СЗА.Материалы и методы. Проведено стоматологическое обследование по показателям пародонтального, глоссального и иммунного статусов 114 мужчин, в том числе 47 пациентов СЗА II стадии и 67 человек без СЗА в анамнезе. Для статистического анализа использовались критерии Хи-квадрат Пирсона, Манна – Уитни, логистическая регрессия, факторный анализ.Результаты. У больных СЗА достоверно хуже уровень гигиены полости рта (p &lt; 0,001) и в 35,5 раза выше вероятность возникновения средней и высокой интенсивности воспаления десны (p &lt; 0,001). Среди пациентов СЗА преобладали секстанты с кровоточивостью (39,0%) и зубным камнем (25,9%), в группе сравнения большинство секстантов были здоровыми (85,8%). По всем кодам CPI, кроме кода 4, выявлены существенные межгрупповые различия (p &lt; 0,001). На дорсальной поверхности языка больных СЗА превалировал налет (63,8%) и незначительный гиперкератоз (27,7%), в группе сравнения отсутствовали изменения у 34,3% и имелся налет у 38,8% (р = 0,003). Спрогнозировано повышение риска удовлетворительной и плохой гигиены полости рта в 3,7 раза (p = 0,007) и средней и тяжелой степени воспаления десны в 6,5 раза (p = 0,015) при наличии изменений на слизистой языка среди обследованных. Получены различия по уровню IgG, ФНО-α и кортизола с преобладанием среди больных СЗА (p &lt; 0,001).Заключение. У больных СЗА статистически значимо превалирует тяжесть заболеваний пародонта, изменения слизистой дорсальной поверхности языка, выражен дисбаланс показателей мукозального иммунитета. Рассмотренные стоматологические маркеры хронической алкогольной интоксикации предложено использовать на стоматологическом приеме по обращаемости и на профилактических осмотрах для скрининга лиц наркологического риска.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. Oral health problems, particularly periodontal diseases, are frequent complications in people with alcohol dependence syndrome (ADS). The assessment of the periodontal, immune status and the tongue condition in ADS patients by the set of indices is promising.Materials and methods. The periodontal and immune status and the tongue condition were examined in 114 men, of whom 47 were patients with stage II ADS and 67 were subjects without a history of ADS. Pearson's chi-squared test, Mann–Whitney U test, logistic regression, factor analysis were used for statistical analysis.Results. ADS patients have significantly worse oral hygiene (p &lt; 0.001) and 35.5 times higher probability of moderate to severe gum inflammation (p &lt; 0.001). Sextants with bleeding (39.0%) and calculus (25.9%) prevailed among ADS patients whereas most of sextants were healthy (85.8%) in the comparison group. Significant inter-group differences were found for all CPI codes except code 4 (p &lt; 0.001). The dorsal surface tongue coating (63.8%) and minor hyperkeratosis (27.7%) prevailed among ADS patients, while in the comparison group, there were no changes in 34.3% of subjects and coating was present in 38.8% (p = 0.003). The risk of satisfactory to poor oral hygiene was 3.7 times (p = 0.007) higher and the risk of moderate to severe gum inflammation was predicted to be 6.5 times (p = 0.015) higher if the examined subjects had changes in the tongue mucosa. The obtained differences in the level of IgG, TNF-α and cortisol prevailed in ADS patients (p &lt; 0.001).Conclusion. In ADS patients, the severity of periodontal diseases, changes in the tongue mucosa and mucosal immunity imbalance are statistically significant. The considered dental markers of chronic alcohol intoxication are proposed to be used at the treatment and checkup dental visits to screen individuals at risk of alcohol use disorder.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром зависимости от алкоголя</kwd><kwd>пародонтальный</kwd><kwd>глоссальный</kwd><kwd>иммунный статус</kwd></kwd-group><kwd-group xml:lang="en"><kwd>alcohol dependence syndrome</kwd><kwd>tongue</kwd><kwd>periodontal</kwd><kwd>immune status</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Орехова Л.Ю., Пачкория М.Г., Яманидзе Н.А. 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