periodontologyПародонтологияParodontologiya1683-37591726-7269Russian Periodontal Association (RPA)10.33925/1683-3759-2021-26-3-211-222periodontology-535Research ArticleОБЗОРREVIEWАктуальность применения нестероидных противовоспалительных препаратов в пародонтологииRelevance of non-steroidal anti-inflammatory drugs in periodontologyhttps://orcid.org/0000-0002-8026-0800ОреховаЛ. Ю.OrekhovaL. Yu.

Орехова Людмила Юрьевна, доктор медицинских наук, профессор, заведующая кафедрой терапевтической стоматологии и пародонтологии

Санкт-Петербург

Liudmila Yu. Orekhova, DMD, PhD, DSc, Professor, Head of the Department of Operative Dentistry and Periodontology

Saint Petersburg 

prof_orekhova@mail.ruhttps://orcid.org/0000-0003-1094-7209ЛободаЕ. С.LobodaE. S.

Лобода Екатерина Сергеевна, кандидат медицинских наук, доцент, доцент кафедры стоматологии терапевтической и пародонтологии

Санкт-Петербург

Ekaterina S. Loboda, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology

Saint Petersburg 

ekaterina.loboda@gmail.comhttps://orcid.org/0000-0002-4141-1370АтрушкевичВ. Г.AtrushkevichV. G.

Атрушкевич Виктория Геннадьевна, доктор медицинских наук, профессор, профессор кафедры пародонтологии

Москва

Victoria G. Atrushkevich, DMD, PhD, DSc, Professor, Department of periodontology

Moscow 

atrushkevichv@mail.ruhttps://orcid.org/0000-0003-3433-3623КосоваЕ. В.KosovaE. V.

Косова Елена Владимировна, кандидат медицинских наук, доцент кафедры стоматологии терапевтической и пародонтологии

Санкт-Петербург

Elena V. Kosova, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology

Saint Petersburg 

kosova.ev@bk.ruhttps://orcid.org/0000-0001-5548-4389ВашневаВ. Ю.VashnevaV. Yu.

Вашнева Вероника Юрьевна, кандидат медицинских наук, доцент кафедры стоматологии терапевтической и пародонтологии

Санкт-Петербург

Veronica Yu. Vashneva, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology

Saint Petersburg 

veronicakrylova@yandex.ruhttps://orcid.org/0000-0002-8813-4577ПетровА. А.PetrovA. A.

Петров Александр Александрович, аспирант кафедры стоматологии терапевтической и пародонтологии

Санкт-Петербург

Alexander A. Petrov, DMD, PhD student, department of Operative Dentistry and Periodontology

Saint Petersburg

paa_stom@mail.ruПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова; ООО «Городской пародонтологический центр ПАКС»РоссияPavlov First Saint Petersburg State Medical University; «PAKS» City Periodontal CenterRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian FederationПервый Санкт-Петербургский государственный медицинский университет им. академика И.П. ПавловаРоссияPavlov First Saint Petersburg State Medical UniversityRussian Federation202103112021263211222Copyright © Орехова Л.Ю., Лобода Е.С., Атрушкевич В.Г., Косова Е.В., Вашнева В.Ю., Петров А.А., 20212021Орехова Л.Ю., Лобода Е.С., Атрушкевич В.Г., Косова Е.В., Вашнева В.Ю., Петров А.А.Orekhova L.Y., Loboda E.S., Atrushkevich V.G., Kosova E.V., Vashneva V.Y., Petrov A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.parodont.ru/jour/article/view/535

Актуальность. Нестероидные противовоспалительные препараты (НПВП) часто назначаются в стоматологической практике для снятия боли и отека. В настоящем исследовании рассматривается информация о НПВС с особым акцентом на те аспекты, которые имеют отношение к стоматологической практике.Материалы и методы. Проведен систематический поиск литературы, в который были включены исследования, датированные с 1970 года по июнь 2021 года. Исследования были выявлены путем поиска в электронных базах данных e-LIBRARY.ru, Embase, Pubmed и Medline. Статьи рассматривались при соблюдении критериев включения и невключения.Результаты. Первоначально в результате электронного поиска данных было выявлено 589 исследований. После изучения названий и аннотаций 69 потенциально релевантных исследования были подвергнуты полнотекстовой оценке. Из них 34 исследования были исключены на основании дизайна исследования, исследовательского вопроса или отсутствия числовых данных по всем переменным, подлежащим оценке в данном исследовании, поэтому 35 исследований с подробным перечнем таких данных могли быть включены в количественное сравнение.Заключение. Применение нестероидных противовоспалительных препаратов обладают потенциалом для изменения воспалительной реакции в тактике лечения стоматологических заболеваний. Исходя из данных проведенных исследований возникает вопрос эффективности и внедрения альтернативных способов использования НПВС в стоматологии, в частности использования их диспергируемых форм.

Relevance. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed in dental practice to relieve pain and swelling. This study reviews information on NSAIDs, with a particular focus on those aspects that are relevant to the practice of dentistry.Materials and methods. A systematic literature search was conducted, which included studies dating from 1970 to June 2021. The search in the electronic databases e-LIBRARY.ru, Embase, Pubmed and Medline identified the studies. Articles were reviewed by meeting the inclusion and non-inclusion criteria.Results. Initially, the electronic search identified 589 studies. After reviewing the titles and abstracts, 69 potentially relevant studies were subject to full-text evaluation. Of these, 34 studies were excluded based on study design, research question, or lack of numerical data on all variables to be assessed in this study, so 35 studies with a detailed list of such data could be included in the quantitative comparison.Conclusion. The use of non-steroidal anti-inflammatory drugs may alter the inflammatory response in the treatment of oral diseases. The conducted studies have brought up questions about the effectiveness and alternative ways of NSAID delivery in dentistry, namely, dispersible formulation.

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The authors declare that there are no conflicts of interest present.