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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2021-26-4-275-283</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-565</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Роль Enterococcus faecalis при апикальном периодонтите</article-title><trans-title-group xml:lang="en"><trans-title>The role of Enterococcus faecalis in apical periodontitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1000-2240</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранцевич</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Barantsevitch</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранцевич Наталья Евгеньевна, научный сотрудник</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Natalya E. Barantsevich, Researcher</p><p>Saint Petersburg</p></bio><email xlink:type="simple">natabara@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8026-0800</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орехова</surname><given-names>Л. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Orekhova</surname><given-names>L. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Орехова Людмила Юрьевна, доктор медицинских наук, профессор, заведующая кафедрой стоматологии терапевтической и пародонтологии, президент Российской пародонтологической ассоциации</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Liudmila Yu. Orekhova, DMD, PhD, DSc, Professor, Head of the Department of Restorative Dentistry and  Periodontology, President of the Russian Periodontal Association</p><p>Saint Petersburg</p></bio><email xlink:type="simple">prof_orekhova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4800-3345</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баранцевич</surname><given-names>Е. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Barantsevitch</surname><given-names>E. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баранцевич Елена Петровна, доктор медицинских наук, заведующая научно-исследовательским отделом микробиологии и внутрибольничных инфекций</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Barantsevich Elena Petrovna, MD, PhD, DSc, Head of the Research Department of Microbiology and Nosocomial Infections</p><p>Saint Petersburg</p></bio><email xlink:type="simple">lenabara2003@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр им. В. А. Алмазова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre, Saint Petersburg</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Первый Санкт-Петербургский государственный университет им. академика И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pavlov First Saint Petersburg State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>20</day><month>01</month><year>2022</year></pub-date><volume>26</volume><issue>4</issue><fpage>275</fpage><lpage>283</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баранцевич Н.Е., Орехова Л.Ю., Баранцевич Е.П., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Баранцевич Н.Е., Орехова Л.Ю., Баранцевич Е.П.</copyright-holder><copyright-holder xml:lang="en">Barantsevitch N.E., Orekhova L.Y., Barantsevitch E.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/565">https://www.parodont.ru/jour/article/view/565</self-uri><abstract><p>Актуальность. Апикальный периодонтит – одно из самых распространенных заболеваний периодонта. Enterococcus faecalis, естественным местообитанием которого является кишечник, относительно редко колонизирует слизистые полости рта здоровых лиц – в 1-20% случаев, однако его выявляют у 68% больных с инфекционными заболеваниями полости рта (кариесом, пульпитом, пародонтитом и др.) и особенно у пациентов с отягощенным соматическим анамнезом, например с сахарным диабетом (в 60% случаев). Это может изменить профиль риска прогрессирования воспалительных заболеваний пародонта, обусловленных появлением в полости рта нехарактерных представителей патогенной микробиоты. При развитии первичного апикального периодонтита микроорганизмы распространяются в пародонт, как правило, из некротизированных тканей пульпы зуба, при вторичном – из корневых каналов, уже подвергшихся эндодонтическому лечению. E. faecalis обладает уникальными свойствами – устойчивостью к физическим и химическим факторам, к дефициту питательных веществ, что приводит к селекции этого микроорганизма при развитии вторичного апикального периодонтита. Его обнаруживают в 30-90% проб из корневых каналов при этой патологии. Важно, что 33% случаев неудач при лечении вторичного апикального периодонтита связаны с инфекцией этим микроорганизмом. Для E. faecalis характерна природная и часто приобретенная резистентность к местным и системным антимикробным препаратам.</p><p>Таким образом, для успешной терапии апикального периодонтита крайне важным представляется идентификация микроорганизма и/или определение состава микробного сообщества, обусловившего его развитие с определением чувствительности к антимикробным препаратам, особенно в связи с высокой частотой ассоциации этого заболевания с инфицированием области поражения E. faecalis.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. Apical periodontitis is one of the most common periodontal diseases. Enterococcus faecalis, which naturally inhabits the intestine, relatively rarely colonizes the oral mucosa of healthy individuals – in 1-20% of cases. However, 68% of patients with oral infectious diseases (caries, pulpitis, periodontitis, etc.) demonstrate it, especially patients with comorbidity, e.g., diabetes mellitus (60% of cases). It may change the risk profile of the inflammatory periodontal disease progression caused by the appearance of unusual pathogens in the oral cavity. In the primary apical periodontitis, microorganisms usually spread into the periodontium from necrotized tissues of the tooth pulp, in secondary periodontitis – from the endodontically treated root canals. E faecalis has unique properties, i.e. resistance to physical and chemical factors, nutrient deficiency, which leads to the selection of this microorganism during the development of secondary apical periodontitis. 30-90% of root canals demonstrate this microorganism in this pathology. 33% of secondary apical periodontitis treatment fail due to this microorganism infection. E. faecalis exhibits natural and often acquired resistance to local and systemic antimicrobial drugs.Thus, successful treatment of apical periodontitis requires identifying the microorganism and/or determining the composition of the microbial community that caused its development and determination of sensitivity to antimicrobial drugs due to the high frequency of association of this disease with i nfection of the affected area of E. faecalis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вторичный апикальный периодонтит</kwd><kwd>микроорганизмы</kwd><kwd>E. faecalis</kwd><kwd>резистентность</kwd><kwd>местная терапия</kwd><kwd>системные антибиотики</kwd></kwd-group><kwd-group xml:lang="en"><kwd>secondary apical periodontitis</kwd><kwd>microorganisms</kwd><kwd>E. faecalis</kwd><kwd>resistance</kwd><kwd>local therapy</kwd><kwd>systemic antibiotics</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nair PN. 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