<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2022-27-2-126-133</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-630</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Интегральная характеристика показателей ультразвуковой доплерографии при оценке состояния гемодинамики в тканях пародонта</article-title><trans-title-group xml:lang="en"><trans-title>Integral characteristics of Doppler ultrasound parameters in periodontal status assessment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4809-1338</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бондарчук</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bondarchuk</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бондарчук Александра Вадимовна, ассистент кафедры пропедевтики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Aleksandra V. Bondarchuk, DMD, Assistant Professor, Department of Introduction to Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">freya090994@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7181-8211</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харах</surname><given-names>Я. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharakh</surname><given-names>Y. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ясер Насерович Харах, кандидат медицинских наук, доцент кафедры пропедевтики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Yaser N. Kharakh, DMD, PhD, Associate Professor, Department of Introduction to Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">c.kharakh@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5380-1475</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киракосян</surname><given-names>Л. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirakosyan</surname><given-names>L. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Киракосян Левон Гамлетович, ассистент кафедры пропедевтики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Levon G. Kirakosyan, DMD, Assistant Professor, Department of Introduction to Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">dr.lkirakosyan@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1003-6667</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карпова</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Karpova</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карпова Вероника Марковна, кандидат медицинских наук, доцент кафедры пропедевтики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Veronika M. Karpova, DMD, PhD, Associate Professor, Department of Introduction to Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">karpovavm82@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6512-8724</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арутюнов</surname><given-names>С. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Arutyunov</surname><given-names>S. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергей Дарчоевич Арутюнов, доктор медицинских наук, профессор, заведующий кафедрой пропедевтики стоматологических заболеваний</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey D. Arutyunov, DMD, PhD, DSc,  Professor, Head of the Department of Introduction to Dental Diseases</p><p>Moscow</p></bio><email xlink:type="simple">sd.arutyunov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А. И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>20</day><month>05</month><year>2022</year></pub-date><volume>27</volume><issue>2</issue><fpage>126</fpage><lpage>133</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бондарчук А.В., Харах Я.Н., Киракосян Л.Г., Карпова В.М., Арутюнов С.Д., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Бондарчук А.В., Харах Я.Н., Киракосян Л.Г., Карпова В.М., Арутюнов С.Д.</copyright-holder><copyright-holder xml:lang="en">Bondarchuk A.V., Kharakh Y.N., Kirakosyan L.G., Karpova V.M., Arutyunov S.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/630">https://www.parodont.ru/jour/article/view/630</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Нарушения микроциркуляции являются одним из ведущих механизмов в патогенезе воспалительных и дистрофических заболеваний пародонта. Для диагностики гемодинамики в современной медицине используется метод ультразвуковой доплерографии, имеющий ряд существенных для исследователя преимуществ. Однако возможности интерпретации данных ультразвуковой доплерографии в научной литературе остаются недостаточно освященными.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. У 40 пациентов обоих полов в возрасте от 18 до 25 лет с клинически интактным пародонтом методом ультразвуковой доплерографии было проведено исследование микроциркуляции в области зуба 1.6 на уровнях свободной десны, прикрепленной десны и переходной складки, с целью изучения интегральной характеристики показателей ультразвуковой доплерографии тканевого кровотока. На основе полученных данных был проведен статистический анализ методом анализа главных компонент.</p></sec><sec><title>Результаты</title><p>Результаты. На основе анализа главных компонент показателями, наиболее близкими к интегральной скорости кровотока, определены Vam и Qam, а оптимальной точкой локализации датчика – область прикрепленной десны.</p></sec><sec><title>Заключение</title><p>Заключение. В ходе анализа главных компонент удалось получить интегральный показатель скорости кровотока (ГК 1), а также его особенности в различных областях пародонта зуба 1.6. Необходимы дополнительные исследования ввиду возможной изменчивости показателей микроциркуляции пародонта в области остальных зубов верхней и нижней челюсти.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Microcirculation disorder is one of the leading mechanisms in the pathogenesis of inﬂammatory and degenerative periodontal diseases. Modern medicine assesses the blood ﬂow by the Doppler ultrasound, which has some essential advantages for a researcher. However, the possibilities of interpreting Doppler ultrasound data remain scarcely enlightened in the scientiﬁc literature.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Forty patients of both sexes, aged 18–25 years, with clinically intact periodontium, underwent a Doppler ultrasound test to investigate microcirculation in the area of tooth 1.6 at the levels of free gingiva, attached gingiva and mucobuccal fold, to study the integral characteristics of a Doppler ultrasound of tissue blood ﬂow. The obtained data were statistically analyzed using the method of principal component analysis.</p></sec><sec><title>Results</title><p>Results. The principal component analysis demonstrated that Vam and Qam were the parameters closest to the integral blood ﬂow velocity, and the attached gingiva was the optimal point for transducer position.</p></sec><sec><title>Conclusion</title><p>Conclusion. The principal component analysis allowed obtaining an integral parameter of blood ﬂow velocity (PC 1) and its features in various areas of the periodontium on tooth 1.6. Further studies are necessary due to the possible variability of periodontal microcirculation on other maxillary and mandibular teeth.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ультразвуковое исследование</kwd><kwd>доплерография</kwd><kwd>диагноз</kwd><kwd>пародонт</kwd><kwd>стоматологическая диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ultrasound study</kwd><kwd>Doppler ultrasound</kwd><kwd>diagnosis</kwd><kwd>periodontium</kwd><kwd>oral diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Canjau S, Todea C. Minimally-invasive diagnostic approaches in periodontics: laser Doppler imaging and optical coherence tomography. Clinical Dentistry Reviewed. 2021;5(1). doi: 10.1007/s41894-021-00099-x</mixed-citation><mixed-citation xml:lang="en">Canjau S, Todea C. Minimally-invasive diagnostic approaches in periodontics: laser Doppler imaging and optical coherence tomography. Clinical Dentistry Reviewed. 2021;5(1). doi: 10.1007/s41894-021-00099-x</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Todea C, Canjau S, Miron M, Vitez B, Noditi B.V. Laser Doppler Flowmetry Evaluation of the Microcirculation in Dentistry. In: Lenasi H editor. Microcirculation Revisited – From Molecules to Clinical Practice [ebook]. London: IntechOpen; 2016 [cited 2022 Apr 28]. doi: 10.5772/64926</mixed-citation><mixed-citation xml:lang="en">Todea C, Canjau S, Miron M, Vitez B, Noditi B.V. Laser Doppler Flowmetry Evaluation of the Microcirculation in Dentistry. In: Lenasi H editor. Microcirculation Revisited – From Molecules to Clinical Practice [e-book]. London: IntechOpen; 2016 [cited 2022 Apr 28 doi: 10.5772/64926</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Benedek T, Rodean I, Ratiu M, Rat N, Yero Eremie L, Biris C, et al. Periodontal disease, inflammation and atherosclerotic progression in patients with acute coronary syndromes – the ATHERODENT study. Journal of Cardiovascular Emergencies. 2018;4(1):17–23. doi: 10.2478/jce-2018-0001</mixed-citation><mixed-citation xml:lang="en">Benedek T, Rodean I, Ratiu M, Rat N, Yero Eremie L, Biris C, et al. Periodontal disease, inflammation and atherosclerotic progression in patients with acute coronary syndromes – the ATHERODENT study. Journal of Cardiovascular Emergencies. 2018;4(1):17–23. doi: 10.2478/jce-2018-0001</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Орехова ЛЮ, Александрова АА, Александрова ЛА, Мусаева РС, Толибова ГХ, Посохова ЭВ. Состояния ротовой полости у беременных при различных типах сахарного диабета: клиническая и цитологическая характеристика. Журнал акушерства и женских болезней. 2016;65(6):45–51. doi: 10.17816/JOWD65645-51</mixed-citation><mixed-citation xml:lang="en">Orekhova LYu, Aleksandrova AA, Aleksandrova LA, Musaeva RS, Tolibova GKh, Posokhova EV. Clinical and cytological characteristic of a condition of the oral cavity at pregnant women with various types of a diabetes mellitus. Journal of obstetrics and womans diseases. 2016;65(6):45–51 (In Russ.). doi: 10.17816/JOWD65645-51.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Yang PY, Chen YT, Wang YH, Su NY, Yu HC, Chang YC. Malignant transformation of oral submucous fibrosis in Taiwan: a nationwide population-based retrospective cohort study. Journal of Oral Pathology and Medicine. 2017;46(10):1040–1045. doi: 10.1111/jop.12570</mixed-citation><mixed-citation xml:lang="en">Yang PY, Chen YT, Wang YH, Su NY, Yu HC, Chang YC. Malignant transformation of oral submucous fibrosis in Taiwan: a nationwide population-based retrospective cohort study. Journal of Oral Pathology and Medicine. 2017;46(10):1040–1045. doi: 10.1111/jop.12570</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kerdvongbundit V, Vongsavan N, Soo-Ampon S, Hasegawa A. Microcirculation and micromorphology of healthy and inflamed gingivae. Odontology. 2003;91(1):19–25. doi: 10.1007/s10266-003-0024-z</mixed-citation><mixed-citation xml:lang="en">Kerdvongbundit V, Vongsavan N, Soo-Ampon S, Hasegawa A. Microcirculation and micromorphology of healthy and inflamed gingivae. Odontology. 2003;91(1):19–25. doi: 10.1007/s10266-003-0024-z</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rodríguez-Martınez M, Patiño-Marín N, Loyola-Rodríguez JP, Brito-Orta MD. Gingivitis and periodontitis as antagonistic modulators of gingival perfusion. Journal of periodontology. 2006;77(10):1643–1650. doi: 10.1902/jop.2006.050311</mixed-citation><mixed-citation xml:lang="en">Rodríguez-Martınez M, Patiño-Marín N, Loyola-Rodríguez JP, Brito-Orta MD. Gingivitis and periodontitis as antagonistic modulators of gingival perfusion. Journal of periodontology. 2006;77(10):1643–1650. doi: 10.1902/jop.2006.050311</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kouadio AA, Jordana F, Koffi NJ, Le Bars P, Soueidan A. The use of laser Doppler flowmetry to evaluate oral soft tissue blood flow in humans: A review. Archives of oral biology. 2018;86:58–71. doi: 10.1016/j.archoralbio.2017.11.009</mixed-citation><mixed-citation xml:lang="en">Kouadio AA, Jordana F, Koffi NJ, Le Bars P, Soueidan A. The use of laser Doppler flowmetry to evaluate oral soft tissue blood flow in humans: A review. Archives of oral biology. 2018;86:58–71. doi: 10.1016/j.archoralbio.2017.11.009</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gou H, Fan R, Chen X, Li L, Wang X, Xu Y, et al. Adjunctive effects of laser therapy on somatosensory function and vasomotor regulation of periodontal tissues in patients with periodontitis: A randomized controlled clinical trial. Journal of periodontology. 2020;91(10):1307–1317. doi: 10.1002/JPER.19-0562</mixed-citation><mixed-citation xml:lang="en">Gou H, Fan R, Chen X, Li L, Wang X, Xu Y, et al. Adjunctive effects of laser therapy on somatosensory function and vasomotor regulation of periodontal tissues in patients with periodontitis: A randomized controlled clinical trial. Journal of periodontology. 2020;91(10):1307–1317. doi: 10.1002/JPER.19-0562</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">To M, Matsuo M, Wada-Takahashi S, Sugiyama S, Tamaki K, Takahashi SS. Microcirculation changes in gingival tissue after ultrasonic tooth preparation in beagle dogs. Journal of applied oral science: revista FOB. 2020;28:1-9. doi: 10.1590/1678-7757-2019-0145</mixed-citation><mixed-citation xml:lang="en">To M, Matsuo M, Wada-Takahashi S, Sugiyama S, Tamaki K, Takahashi SS. Microcirculation changes in gingival tissue after ultrasonic tooth preparation in beagle dogs. Journal of applied oral science: revista FOB. 2020;28:1-9. doi: 10.1590/1678-7757-2019-0145</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nakamoto T, Kanao M, Kondo Y, Kajiwara N, Masaki C, Takahashi T, и др. Two-dimensional real-time blood ﬂow and temperature of soft tissue around maxillary anterior implants. Implant dentistry. 2012;21(6):522–527. doi: 10.1097/ID.0b013e318272fe81</mixed-citation><mixed-citation xml:lang="en">Nakamoto T, Kanao M, Kondo Y, Kajiwara N, Masaki C, Takahashi T, et al. Two-dimensional real-time blood flow and temperature of soft tissue around maxillary anterior implants. Implant dentistry. 2012;21(6):522–527. doi: 10.1097/ID.0b013e318272fe81</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Patiño-Marín N, Martínez F, Loyola-Rodríguez JP, Tenorio-Govea E, Brito-Orta MD, Rodríguez-Martínez M. A novel procedure for evaluating gingival perfusion status using laser-Doppler flowmetry. Journal of clinical periodontology. 2005;32(3):231–237. doi: 10.1111/j.1600-051X.2005.00655.x</mixed-citation><mixed-citation xml:lang="en">Patiño-Marín N, Martínez F, Loyola-Rodríguez JP, Tenorio-Govea E, Brito-Orta MD, Rodríguez-Martínez M. A novel procedure for evaluating gingival perfusion status using laser-Doppler flowmetry. Journal of clinical periodontology. 2005;32(3):231–237. doi: 10.1111/j.1600-051X.2005.00655.x</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Yamamoto R, Amano K, Takahashi SW, To M, Takahashi S, Matsuo M. Changes in the microcirculation in periodontal tissue due to experimental peri-implantitis. Journal of oral biosciences. 2021;63(2):153–160. doi: 10.1016/j.job.2021.03.002</mixed-citation><mixed-citation xml:lang="en">Yamamoto R, Amano K, Takahashi SW, To M, Takahashi S, Matsuo M. Changes in the microcirculation in periodontal tissue due to experimental peri-implantitis. Journal of oral biosciences. 2021;63(2):153–160. doi: 10.1016/j.job.2021.03.002</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Кречина ЕК, Маслова ВВ, Рахимова ЭН. Определение гемомикроциркуляции в тканях пародонта с использованием методов лазерной и ультразвуковой допплерографии [Электронный ресурс]. Москва: ЦНИИС и ЧЛХ Росмедтехнологий; 2008 [дата обращения 2022 Апр 28]. Режим доступа: https://www.cniis.ru/downloads/download_private/scientific/files/technology_n5_doppler.pdf.</mixed-citation><mixed-citation xml:lang="en">Krechina EK, Maslova VV, Rakhimova EN. Determination of hemomicrocirculation in periodontal tissues using laser and ultrasound Dopplerography [ebook]. Moscow: TSNIIS and ChLH of Rosmedtechnologies; 2008 [cited 2022 Apr 28] (In Russ.). Available from: https://www.cniis.ru/downloads/download_private/scientific/files/technology_n5_doppler.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Орехова ЛЮ, Лобода ЕС, Яманидзе Н. Значение ультразвуковой допплерографии в динамике лечения воспалительных заболеваний пародонта. Евразийский союз ученых. 2016;30:89–94. Режим доступа: https://elibrary.ru/item.asp?id=27316055</mixed-citation><mixed-citation xml:lang="en">Orekhova LYu, Loboda EU, Yamanidze N. The signiﬁcance of the ultrasound doppler during the treatment of inﬂammatory periodontal diseases. Eurasian Union of Scientists. 2016;30:89–94 (In Russ.). Available from: https://elibrary.ru/item.asp?id=27316055</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Ahn SY, Kim D, Park SH. Efficacy of Ultrasound Doppler Flowmetry in Assessing Pulp Vitality of Traumatized Teeth: A Propensity Score Matching Analysis. Journal of endodontics. 2018;44(3):379–383. doi: 10.1016/j.joen.2017.10.004</mixed-citation><mixed-citation xml:lang="en">Ahn SY, Kim D, Park SH. Efficacy of Ultrasound Doppler Flowmetry in Assessing Pulp Vitality of Traumatized Teeth: A Propensity Score Matching Analysis. Journal of endodontics. 2018;44(3):379–383. doi: 10.1016/j.joen.2017.10.004</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Арутюнов СД, Бондарчук АВ, Атрушкевич ВГ, Золотницкий ИВ, Пивоваров АА, авторы; Арутюнов СД, патентообладатель. Устройство для мониторинга гемодинамики тканей пародонта. Пат. 2758963 Рос. Федерация. Опубл. 03.11.2021.</mixed-citation><mixed-citation xml:lang="en">Arutyunov SD, Bondarchuk АV, Atrushkevich VG, Zolotnitsky IV, Pivovarov AA, inventors; Arutyunov SD, assignee. Device for monitoring hemodynamics of periodontal tissues. Russian Federation patent RU 2758963. 2021 Nov 03 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jackson DA. Stopping rules in principal component analysis: a comparison of heuristical and statistical approaches. Ecology. 1993;74(8):2204–2214. doi: 10.2307/1939574</mixed-citation><mixed-citation xml:lang="en">Jackson DA. Stopping rules in principal component analysis: a comparison of heuristical and statistical approaches. Ecology. 1993;74(8):2204–2214. doi: 10.2307/1939574</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Jolliffé IT, редактор. Principal component analysis. New York: Springer-Verlag; 2002. 486 с.</mixed-citation><mixed-citation xml:lang="en">Jolliffé IT, editor. Principal component analysis. New York: Springer-Verlag; 2002. 486 p.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Osborne JW. Improving your data transformations: applying the Box-Cox transformation. Practical Assessment, Research &amp; Evaluation. 2010;15(12):1–9. doi: 10.7275/QBPC-GK17</mixed-citation><mixed-citation xml:lang="en">Osborne JW. Improving your data transformations: applying the Box-Cox transformation. Practical Assessment, Research &amp; Evaluation. 2010;15(12):1–9. doi: 10.7275/QBPC-GK17</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
