periodontologyПародонтологияParodontologiya1683-37591726-7269Russian Periodontal Association (RPA)10.33925/1683-3759-2023-792periodontology-792Research ArticleОБЗОРREVIEWЗначение Veillonella в микробиоме полости рта и ее влияние на патологию зубов и пародонта. Обзор литературыThe importance of Veillonella in the oral microbiome and its impact on dental and periodontal pathology: a literature reviewhttps://orcid.org/0000-0002-4243-4689СагановаТ. Р.SaganovaT. R.

Москва

Tatiana R. Saganova, MD, Junior Researcher, Laboratory of Molecular Biological Research, Research Institute of Medicine and Dentistry

Moscow

saganova.tatiana@yandex.ruhttps://orcid.org/0000-0002-3311-0367ЦаревВ. Н.TsarevV. N.

Москва

Victor N. Tsarev, DMD, PhD, DSc, Professor, Director of the Research Institute of Medicine and Dentistry, Head of the Department Microbiology, Virology, Immunology

Moscow

nikola777@rambler.ruhttps://orcid.org/0000-0002-5983-9674ДжанниА. Б.GianniA. B.

Милан

Aldo Bruno Gianni , MD, PhD, DSc, Professor, Head of the Department of Biomedical, Surgical and Dental Sciences

Milan

aldo.gianni@unimi.ithttps://orcid.org/0000-0002-6691-736XСиньориниЛ.SignoriniL.

Милан

Lucia Signorini, MD, PhD, Fixed Term researcher, Department of Biomedical, Surgical and Dental Sciences

Milan

lucia.signorini@unimi.itКаваллеЭ.CavalléE.

Милан

Edoardo Cavallé, MD, PhD, Assistant Professor, Departmet of the Oral Pathology

Milan

edoardocavalle@email.itМосковский государственный медико-стоматологический университет имени А. И. ЕвдокимоваРоссияA. I. Evdokimov Moscow State University of Medicine and DentistryRussian FederationУниверситет МиланаИталияUniversity of MilanItalyУниверситет Милана-БикоккаИталияUniversity of Milan-BicoccaItaly202327092023283Принято в печать218226Copyright © Саганова Т.Р., Царев В.Н., Джанни А.Б., Синьорини Л., Кавалле Э., 20232023Саганова Т.Р., Царев В.Н., Джанни А.Б., Синьорини Л., Кавалле Э.Saganova T.R., Tsarev V.N., Gianni A.B., Signorini L., Cavallé E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.parodont.ru/jour/article/view/792Актуальность

Актуальность. Вейлонеллы связаны с заболеваниями полости рта. Представители этого рода занимают значительную долю в составе микробиоты зубного налета (бляшки) и участвуют в формировании пищевых цепей и регуляции pH микробиома полости рта.

Целью данной статьи является предоставление обзора научных исследований, посвященных положению таксономической группы вейлонелл в микробиоме полости рта и их возможном влиянии на развитие инфекционных заболеваний полости рта.

Материалы и методы

Материалы и методы. Был проведен научный поиск в базах данных MEDLINE, EMBASE, NCBI, Web of Science, PubMed, Scopus и eLibrary.RU за последние 40 лет. Были проанализированы 88 источников на английском языке, 1 на русском языке.

Результаты

Результаты. Различные виды Veillonella способствуют адгезии Streptococcus mutans и метаболизируют лактат, вырабатываемом стрептококками. Они также играют важную роль в формировании микробной биопленки пародонта, вступая в коагрегацию с первичными, промежуточными и поздними колонизаторами, в том числе с такими пародонтопатогенами, как Fusobacterium nucleatum и Porphyromonas gingivalis. Вейлонеллы участвуют в образовании липополисахаридов и сероводорода при пульпите, периапикальном периодонтите и галитозе.

Заключение

Заключение. Veillonella spp. является важным компонентом микробиома полости рта и может рассматриваться как стабилизирующий компонент и как индикатор нарушений метаболической ситуации в экосистеме ниши.

Relevance

Relevance. Veillonella is associated with diseases of the oral cavity. Representatives of this genus occupy a significant share in the composition of the plaque microbiota and are involved in the formation of food chains and regulating the pH of the oral microbiome.

The aim of this article is to provide an overview of scientific studies on the Veillonella taxonomic group's position in the oral microbiome and their possible impact on the development of infectious diseases of the oral cavity.

Materials and methods

Materials and methods. A scientific search was conducted in the databases MEDLINE, EMBASE, NCBI, Web of Science, PubMed, Scopus, and eLibrary.RU for the last 40 years. 88 sources in English and 1 in Russian were analyzed and included in this review.

Results

Results. Various species of Veillonella promote the adhesion of Streptococcus mutans and metabolize the lactate produced by streptococci. They also play an essential role in forming the periodontium microbial biofilm, entering into co-aggregation with primary, intermediate and late colonizers, including such periodontal pathogens as Fusobacterium nucleatum and Porphyromonas gingivalis. Veilonella is involved in the formation of lipopolysaccharides and hydrogen sulfide in pulpitis, periapical periodontitis and halitosis.

Conclusion

Conclusion. Veillonella spp. is a significant component of the oral microbiome and can be viewed as a stabilizing component and as an indicator of a violation of the ecosystem's metabolic situation.

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The authors declare that there are no conflicts of interest present.