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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2023-850</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-850</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Сравнительный анализ эффективности хлоргексидинсодержащих антисептических препаратов, применяемых в пародонтологии и имплантологии</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of chlorhexidine-containing antiseptic agents used in periodontics and implantology</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7019-3053</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богатырева</surname><given-names>Р. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogatyreva</surname><given-names>R. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Богатырева Радима Мурадиновна, кандидат медицинских наук, ассистент кафедры терапевтической стоматологии и пародонтологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Radima M. Bogatyreva, DMD, PhD, Assistan Professor, Department of the Restorative Dentistry and Periodontology</p><p>Moscow</p></bio><email xlink:type="simple">bog-radima@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4527-7471</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слажнева</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Slazhneva</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Слажнева Екатерина Сергеевна, кандидат медицинских наук, доцент кафедры терапевтической стоматологии и пародонтологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina S. Slazhneva, DMD, PhD, Associate Professor, Department of the Restorative Dentistry and Periodontology</p><p>Moscow</p></bio><email xlink:type="simple">ekaterinaslazhneva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0206-0026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Блашкова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Blashkova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Блашкова Юлия Валерьевна, аспирант кафедры терапевтической стоматологии и пародонтологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Yulia V. Blashkova, DMD, PhD student, Department of the Operative Dentistry and Periodontology</p><p>Moscow</p></bio><email xlink:type="simple">blashkova.j@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4141-1370</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Атрушкевич</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Atrushkevich</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Атрушкевич Виктория Геннадьевна, доктор медицинских наук, заведующая кафедрой терапевтической стоматологии и пародонтологии, вице-президент Российской пародонтологической ассоциации</p><p>Москва</p></bio><bio xml:lang="en"><p>Victoria G. Atrushkevich, DMD, PhD, DSc, Professor, Head of the Department of Restorative Dentistry and Periodontology, Vice-President of RPA Moscow</p><p>Moscow</p></bio><email xlink:type="simple">atrushkevichv@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет имени А. И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>A. I. Yevdokimov Moscow State University of Medicine and Dentistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>15</day><month>10</month><year>2023</year></pub-date><volume>28</volume><issue>3</issue><issue-title>Принято в печать</issue-title><fpage>264</fpage><lpage>275</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Богатырева Р.М., Слажнева Е.С., Блашкова Е.В., Атрушкевич В.Г., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Богатырева Р.М., Слажнева Е.С., Блашкова Е.В., Атрушкевич В.Г.</copyright-holder><copyright-holder xml:lang="en">Bogatyreva R.M., Slazhneva E.S., Blashkova Y.V., Atrushkevich V.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/850">https://www.parodont.ru/jour/article/view/850</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Несмотря на разнообразие лекарственных средств с антибактериальным эффектом, в том числе многокомпонентных, золотым стандартом антисептических препаратов, актуальных в терапии заболеваний пародонта, в настоящее время являются хлоргексидинсодержащие. В то же время нежелательные побочные эффекты, новые данные о неблагоприятном воздействии от применения хлоргексидина на микробиом определяют необходимость поиска оптимального хлоргексидинсодержащего продукта, сочетающего высокую эффективность и относительную безвредность. Цель исследования: провести сравнительный анализ эффективности хлоргексидинсодержащих антисептических препаратов, применяемых в стоматологической практике.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Были проанализированы результаты клинических исследований, посвященных изучению эффективности хлоргексидина в терапии заболеваний пародонта, опубликованные в период с 2018 по 2023 год. Подбор публикаций производили в базе данных PubMed по ключевым словам: chlorhexidine, periodontal disease, periodontitis. Общее количество публикаций, отвечающих критериям поиска, составило 84. В результате первичного анализа всех доступных публикаций, согласно критериям включения и не включения было изучено и проанализировано 27 публикации.</p></sec><sec><title>Результаты</title><p>Результаты. В результате анализа данных клинических исследований, проведенных за последние пять лет, было установлено, что в медикаментозном сопровождении терапии заболеваний пародонта обнаруживается тенденция к более частому применению более высоких концентраций препаратов хлоргексидина, таких как 0,12% и 0,2%.</p></sec><sec><title>Заключение</title><p>Заключение. Факт назначения хлоргексидинсодержащих препаратов должен быть обоснованным и отвечать особенностям клинической картины. При этом подбор концентрации действующего вещества хлоргексидина, форма выпуска лекарственного препарата, длительность применения должны быть тщательно подобраны в соответствии с клинической ситуацией и преследуемой целью.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Despite the variety of antibacterial drugs, including multicomponent ones, chlorhexidine-containing antiseptics are nowadays the gold standard of antiseptic products relevant for periodontal therapy. At the same time, adverse side effects and new data about unfavourable chlorhexidine effects on the microbiome determine it necessary to search for a new optimal chlorhexidine-containing product that combines high effectiveness and relative safety. Purpose. The study aimed to compare and analyze the effectiveness of chlorhexidine-containing antiseptics used in dental practice.</p></sec><sec><title>Material and Methods</title><p>Material and Methods. The study analyzed the results of clinical studies published from 2018 to 2023 and devoted to the investigation of chlorhexidine effectiveness in the treatment of periodontal diseases. The publications were searched in the Pub Med database by the keywords 'chlorhexidine', 'periodontal disease', and 'periodontitis'. A total of eighty-four publications corresponded to the search criteria. After the primary analysis of all available publications corresponding to the inclusion and exclusion criteria, we studied and analyzed 32 publications.</p></sec><sec><title>Results</title><p>Results. The analysis of the publications for the past five years extracted a trend for a more frequent increase of chlorhexidine concentrations to 0.12% and 0.2% in periodontal therapy medications.</p></sec><sec><title>Conclusion</title><p>Conclusion. Prescribing chlorhexidine-containing medications should be reasonable and respond to the characteristics of the clinical picture. At that, a thorough selection of chlorhexidine active agent concentration, a form of presentation and duration of use should correspond to the clinical situation and goal.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хлоргексидин</kwd><kwd>микробиом</kwd><kwd>пародонтит</kwd><kwd>гингивит</kwd><kwd>мукозит</kwd><kwd>периимплантит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chlorhexidine</kwd><kwd>microbiome</kwd><kwd>periodontitis</kwd><kwd>gingivitis</kwd><kwd>mucositis</kwd><kwd>periimplantitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. The oral microbiome: Role of key organisms and complex networks in oral health and disease. Periodontol 2000. 2021;87(1):107-131. doi: 10.1111/prd.12393</mixed-citation><mixed-citation xml:lang="en">Sedghi L, DiMassa V, Harrington A, Lynch SV, Kapila YL. 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