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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">periodontology</journal-id><journal-title-group><journal-title xml:lang="ru">Пародонтология</journal-title><trans-title-group xml:lang="en"><trans-title>Parodontologiya</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1683-3759</issn><issn pub-type="epub">1726-7269</issn><publisher><publisher-name>Russian Periodontal Association (RPA)</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33925/1683-3759-2024-929</article-id><article-id custom-type="elpub" pub-id-type="custom">periodontology-929</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИССЛЕДОВАНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>RESEARCH</subject></subj-group></article-categories><title-group><article-title>Функциональная оценка состояния микроциркуляции в тканях зоны инъекции при применении местного обезболивания</article-title><trans-title-group xml:lang="en"><trans-title>Functional assessment of microcirculation in the injection site tissues when using local anaesthesia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7109-6431</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анисимова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Anisimova</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анисимова Евгения Николаевна, кандидат медицинских наук, доцент кафедры стоматологии и челюстно-лицевой хирургии</p><p>Москва</p></bio><bio xml:lang="en"><p>Evgenia N. Anisimova, DMD, PhD, Associate Professor, Department of Dentistry and Maxillofacial Surgery</p><p>Moscow </p></bio><email xlink:type="simple">evg-anis@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3073-7041</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анисимова</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Anisimova</surname><given-names>N. U.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Анисимова Наталья Юрьевна, кандидат медицинских наук, доцент кафедры обезболивания в стоматологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia Yu. Anisimova, DMD, PhD, Associate Professor, Department of Local Anesthesia</p><p>Moscow </p></bio><email xlink:type="simple">dent.natalia@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1698-0368</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орехова</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orekhova</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Орехова Ирина Викторовна, кандидат медицинских наук, доцент кафедры стоматологии и челюстно-лицевой хирургии</p><p>Москва</p></bio><bio xml:lang="en"><p>Irina V. Orekhova, DMD, PhD, Associate Professor, Department of Dentistry and Maxillofacial Surgery</p><p>Moscow </p></bio><email xlink:type="simple">irina-stomdent@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4914-3873</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Першина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Pershina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Першина Любовь Витальевна, кандидат медицинских наук, доцент кафедры стоматологии и челюстно-лицевой хирургии</p><p>Москва</p></bio><bio xml:lang="en"><p>Lubov V. Pershina, DMD, PhD, Associate Professor, Department of Dentistry and Maxillofacial Surgery</p><p>Moscow</p></bio><email xlink:type="simple">pershina.iubov-08@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский биотехнологический университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Biotechnology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский университет медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>24</day><month>06</month><year>2024</year></pub-date><volume>29</volume><issue>2</issue><fpage>179</fpage><lpage>186</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Анисимова Е.Н., Анисимова Н.Ю., Орехова И.В., Першина Л.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Анисимова Е.Н., Анисимова Н.Ю., Орехова И.В., Першина Л.В.</copyright-holder><copyright-holder xml:lang="en">Anisimova E.N., Anisimova N.U., Orekhova I.V., Pershina L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.parodont.ru/jour/article/view/929">https://www.parodont.ru/jour/article/view/929</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. В современной стоматологии основными критериями успешной анестезии являются эффективность и безопасность используемого обезболивания, которые зависят от вида местного анестетика и способа его введения в ткани челюстно-лицевой области. Изучение влияния местноанестезирующего раствора, вводимого различными инъекционными способами, на ткани пародонта возможно регистрацией изменений микроциркуляции методом ЛДФ.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Регистрация базового показателя микроциркуляции в динамике в тканях в зоне инъекции при использовании различных способов и средств местного обезболивания.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Исследование изменений микроциркуляции тканей пародонта проводилось среди 105 пациентов: 67 женщин и 38 мужчин в возрасте от 25 до 56 лет без патологии пародонта и сопутствующих заболеваний с использованием инъекционных способов анестезии (инфильтрационная и модифицированная пародонтальная анестезии) 2% и 4% растворами артикаина с различной концентрацией вазоконстриктора. Изменения показателя микроциркуляции регистрировались в области места вкола анестетика: проекции верхушки корня при инфильтрации и в области зубодесневого сосочка при МПА, время экспозиции во время регистрации ЛДФ составило 5 минут. Для удержания световодного зонда мы использовался индивидуальный ключ, изготовленный из C-силикона с дополнительным коррегирующим слоем при повторном позиционировании. Наиболее информативным показателем исследования явилась величина среднего потока перфузии крови – М в интервале времени регистрации, ее изменения отражались в результатах исследования.</p></sec><sec><title>Результаты</title><p>Результаты. Анализ динамики показателей микроциркуляции тканей в зоне инъекции при использовании различных способов введения местноанестезирующих препаратов на основе 2% и 4% растворов артикаина без вазоконстриктора и с эпинефрином в концентрации 1:200000 и 1:100000 позволил определить глубину ишемизации тканей в зоне инъекции и скорость восстановления кровотока после применения анестезии.</p></sec><sec><title>Заключение</title><p>Заключение. Изменения показателей микроциркуляции в тканях зоны инъекции местноанестезирующего препарата зависят от концентрации местного анестетика и вазоконстриктора, способа используемого введения и объема вводимого препарата.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. In modern dentistry, the primary criteria for successful anaesthesia are the effectiveness and safety of the anaesthetic used. These factors depend on the type of local anaesthetic and the method of its administration in the maxillofacial tissues. Studying the impact of locally anaesthetizing solutions administered by different injection techniques on the periodontal tissues is possible by recording changes in microcirculation using the LDF method.</p></sec><sec><title>Purpose</title><p>Purpose. To dynamically record the baseline microcirculation indicator in the tissues at the injection site when using various methods and means of local anaesthesia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study of changes in the microcirculation of periodontal tissues was conducted among 105 patients: 67 women and 38 men aged 25 to 56 years without periodontal pathology and comorbidities, using injection methods of anaesthesia (infiltration and modified periodontal anaesthesia) with 2% and 4% solutions of articaine with varying concentrations of vasoconstrictor. Changes in the microcirculation index were recorded at the injection site: at the root apex projection during infiltration and in the gingival papilla region during MPA, with an exposure time during LDF registration of 5 minutes. To maintain the fiber optic probe, an individual key made of C-silicone with an additional corrective layer was used for repeat positioning. The most informative indicator of the study was the magnitude of the average blood perfusion flow (M) in the time interval of registration, with its changes reflected in the study results.</p></sec><sec><title>Results</title><p>Results. Analysis of the dynamics of microcirculation indicators in the injection site tissues when using various methods of administering locally anaesthetizing drugs based on 2% and 4% solutions of articaine without vasoconstrictor and with epinephrine at concentrations of 1:200,000 and 1:100,000 allowed the determination of tissue ischemia depth at the injection site and the rate of blood flow restoration after anaesthesia.</p></sec><sec><title>Conclusion</title><p>Conclusion. Changes in microcirculation indicators in the tissues at the injection site of the local anaesthetic depend on the concentration of the local anaesthetic and vasoconstrictor, the method of administration used, and the volume of the drug administered.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>пародонтальные способы анестезии</kwd><kwd>модифицированная пародонтальная анестезия</kwd><kwd>2% артикаин</kwd><kwd>4% артикаин с эпинефрином</kwd></kwd-group><kwd-group xml:lang="en"><kwd>periodontal anaesthesia techniques</kwd><kwd>modified periodontal anaesthesia</kwd><kwd>2% articaine</kwd><kwd>4% articaine with epinephrine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова НЮ, Анисимова ЕН, Рязанцев НА, Кравченко ИА. Сравнительный анализ применения 2% и 4% раствора артикаина при инъекционной местной анестезии. Стоматология. 2021;100(5):25-29. doi: 10.17116/stomat202110005125</mixed-citation><mixed-citation xml:lang="en">Anisimova NY, Anisimova EN, Ryazantcev NA, Kravchenko IA. Comparative analysis of 2% and 4% articaine solution efficacy and safety for the local anesthesia. Stomatology. 2021;100(5):25-29 (In Russ.). doi:10.17116/stomat202110005125</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Анисимова ЕН, Першина ЛВ, Ермольев СН, Орехова ИВ, Летунова НЮ, Рязанцев НА, и др. Разработка способа пародонтальной анестезии при лечении зубов. Институт стоматологии. 2017;3(76):42-48. Режим доступа: https://instom.spb.ru/catalog/article/10945/</mixed-citation><mixed-citation xml:lang="en">Anisimova EN, Ermolev SN, Pershina LV, Letunova NU, Orekhova IV, Ryzancev NA, et al. The method of periodontal anesthesia during dental treatment. The Dental Institute. 2017;(3):38-40 (In Russ). Available from: https://instom.spb.ru/catalog/article/10945/</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Berlin J, Nusstein J, Reader A, Beck M, Weaver J. Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(3):361-6. doi: 10.1016/j.tripleo.2004.11.009</mixed-citation><mixed-citation xml:lang="en">Berlin J, Nusstein J, Reader A, Beck M, Weaver J. Efficacy of articaine and lidocaine in a primary intraligamentary injection administered with a computer-controlled local anesthetic delivery system. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99(3):361-6. doi: 10.1016/j.tripleo.2004.11.009</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hintze A, Paessler L. Comparative investigations on the efficacy of articaine 4% (epinephrine 1:200,000) and articaine 2% (epinephrine 1:200,000) in local infiltration anaesthesia in dentistry a randomised double-blind study. Clinical Oral Investigation. 2006;10(2):145-150. doi: 10.1007/s00784-005-0025-0</mixed-citation><mixed-citation xml:lang="en">Hintze A, Paessler L. Comparative investigations on the efficacy of articaine 4% (epinephrine 1:200,000) and articaine 2% (epinephrine 1:200,000) in local infiltration anaesthesia in dentistry a randomised double-blind study. Clinical Oral Investigation. 2006;10(2):145-150. doi: 10.1007/s00784-005-0025-0</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Brickhouse TH, Unkel JH, Webb MD, Best AiM, Hollowell R. Articaine use in children among dental practitioners. Pediatric Dentistry. 2007;30(6): 516-521. Режим доступа: https://www.researchgate.net/publication/23970919_Articaine_Use_in_Children_Among_Dental_Practitioners</mixed-citation><mixed-citation xml:lang="en">Brickhouse TH, Unkel JH, Webb MD, Best AiM, Hollowell R. Articaine use in children among dental practitioners. Pediatric Dentistry. 2007;30(6): 516-521. Available from: https://www.researchgate.net/publication/23970919_Articaine_Use_in_Children_Among_Dental_Practitioners</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Elheeny AAH. Articaine efficacy and safety in young children below the age of four years: An equivalent parallel randomized control trial. Int J Paediatr Dent. 2020;30(5):547-555. doi: 10.1111/ipd.12640</mixed-citation><mixed-citation xml:lang="en">Elheeny AAH. Articaine efficacy and safety in young children below the age of four years: An equivalent parallel randomized control trial. Int J Paediatr Dent. 2020;30(5):547-555. doi: 10.1111/ipd.12640</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Kämmerer PW, Krämer N, Esch J, Pfau H, Uhlemann U, Piehlmeier L, Daubländer M. Epinephrine-reduced articaine solution (1:400,000) in paediatric dentistry: a multicentre non-interventional clinical trial. Eur Arch Paediatr Dent. 2013;14(2):89-95. doi: 10.1007/s40368-013-0024-9.</mixed-citation><mixed-citation xml:lang="en">Kämmerer PW, Krämer N, Esch J, Pfau H, Uhlemann U, Piehlmeier L, Daubländer M. Epinephrine-reduced articaine solution (1:400,000) in paediatric dentistry: a multicentre non-interventional clinical trial. Eur Arch Paediatr Dent. 2013;14(2):89-95. doi: 10.1007/s40368-013-0024-9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kämmerer PW, Schneider D, Palarie V, Schiegnitz E, Daubländer M. Comparison of anesthetic efficacy of 2 and 4 % articaine in inferior alveolar nerve block for tooth extraction-a double-blinded randomized clinical trial. Clin Oral Investig. 2017;21(1):397-403. doi: 10.1007/s00784-016-1804-5</mixed-citation><mixed-citation xml:lang="en">Kämmerer PW, Schneider D, Palarie V, Schiegnitz E, Daubländer M. Comparison of anesthetic efficacy of 2 and 4 % articaine in inferior alveolar nerve block for tooth extraction-a double-blinded randomized clinical trial. Clin Oral Investig. 2017;21(1):397-403. doi: 10.1007/s00784-016-1804-5</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Rathi NV, Khatri AA, Agrawal AG, M SB, Thosar NR, Deolia SG. Anesthetic Efficacy of Buccal Infiltration Articaine versus Lidocaine for Extraction of Primary Molar Teeth. Anesth Prog. 2019;66(1):3-7. doi: 10.2344/anpr-65-04-02</mixed-citation><mixed-citation xml:lang="en">Rathi NV, Khatri AA, Agrawal AG, M SB, Thosar NR, Deolia SG. Anesthetic Efficacy of Buccal Infiltration Articaine versus Lidocaine for Extraction of Primary Molar Teeth. Anesth Prog. 2019;66(1):3-7. doi: 10.2344/anpr-65-04-02</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Flanagan DF. The effectiveness of articaine in mandibular facial infiltrations. Local Reg Anesth. 2015;9:1-6. doi: 10.2147/LRA.S94647</mixed-citation><mixed-citation xml:lang="en">Flanagan DF. The effectiveness of articaine in mandibular facial infiltrations. Local Reg Anesth. 2015;9:1-6. doi: 10.2147/LRA.S94647</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Meechan JG. The use of the mandibular infiltration anesthetic technique in adults. J Am Dent Assoc. 2011;142 Suppl 3:19S-24S. doi: 10.14219/jada.archive.2011.0343.</mixed-citation><mixed-citation xml:lang="en">Meechan JG. The use of the mandibular infiltration anesthetic technique in adults. J Am Dent Assoc. 2011;142 Suppl 3:19S-24S. doi: 10.14219/jada.archive.2011.0343.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Mittal M, Sharma S, Kumar.A, Chopra R, Srivastava D. Comparison of Anesthetic Efficacy of Articaine and Lidocaine During Primary Maxillary Molar Extractions in Children. Pediatric Dentistry. 2015;37(7):520-524. Режим доступа: https://www.researchgate.net/publication/292447939_Comparison_of_Anesthetic_Efficacy_of_Articaine_and_Lidocaine_During_Primary_Maxillary_Molar_Extractions_in_Children#fullTextFileContent</mixed-citation><mixed-citation xml:lang="en">Mittal M, Sharma S, Kumar.A, Chopra R, Srivastava D. Comparison of Anesthetic Efficacy of Articaine and Lidocaine During Primary Maxillary Molar Extractions in Children. Pediatric Dentistry. 2015;37(7):520-524. Available from: https://www.researchgate.net/publication/292447939_Comparison_of_Anesthetic_Efficacy_of_Articaine_and_Lidocaine_During_Primary_Maxillary_Molar_Extractions_in_Children#fullTextFileContent</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Scardina GA, Pisano T, Cacioppo A, Messina P. Periodontal alteration of the microcirculation and hypercholesterolemia: a possible correlation? South Med J. 2011;104(2):116-20. doi: 10.1097/SMJ.0b013e318205ddf1</mixed-citation><mixed-citation xml:lang="en">Scardina GA, Pisano T, Cacioppo A, Messina P. Periodontal alteration of the microcirculation and hypercholesterolemia: a possible correlation? South Med J. 2011;104(2):116-20. doi: 10.1097/SMJ.0b013e318205ddf1</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
