Influence therapeutic and prophylactic toothpaste on free radical oxidation processes in model systems and oral fluid of patients with chronic gingivitis

Abstract

It was conducted chemiluminescent (CL) study of oral fluid 48 somatically healthy individuals (20 men and 28 women) aged 18 to 24 years and 74 patients (40 men and 34 women) of the same age with chronic gingivitis (CG). The study was performed in HL model systems and oral fluid in vitro and in vivo, radiation light sum evaluated indicators - S and its maximum value - I max during the study. In an experiment to study the effect of toothpastes Parodontax and Sensodyne fluoride CPO processes for model systems. In 33 patients studied showed an increase (S - 36,3 ± 5,4 standard units, I max -15,8 ± 2,1 standard units...), 41 - there was a decrease of intensity of chemiluminescence oral fluid (2,1 ± 0,4 standard units, I max - 0,9 ± 0,06 standard units)... In studying the effect of toothpastes on the processes of free radical oxidation in model systems revealed that the toothpaste Sensodyne fluoride significantly inhibited HL model system, generating ROS. Parodontax - stimulated ROS formation, but at the same time suppresses lipid peroxidation reaction. Similar changes CL showed toothpastes studied when added in vitro to the oral fluid of patients with chronic hepatitis. Our research has shown that using a properly selected toothpastes can correct the status of free radical oxidation in oral fluid.