The relationship of inflammatory diseases in the oral cavity and cardiovascular system. Literature review and determining the level of dental education
https://doi.org/10.33925/1683-3759-2019-24-4-301-307
Abstract
Materials and methods. We carried out the analysis of 11 studies, including 610 patients with cardiovascular disease, who need surgical treatment. After the meta-analysis, we determined the gradation of periodontal pathogens from the most frequently detected in vascular biopsies to the least. We also conducted a sociological interview among 230 people and with the help of its results, we developed a multi-stage dental education program.
Results. Based on the analysis of a number of clinical studies, a positive correlation was observed (in 100% cases) between chronic oral infection and detection of periodontal pathogens in vascular biopsies. Sociological survey showed a low level of awareness between doctors and patients on this issue, and we have identified an actual lack of educational work with patients in doctor`s daily practice.
Conclusion. The analyzed works and modern clinical studies confirm the possible relationship of oral infection with cardiovascular disease, also, the results of the sociological survey motivate us to realize a large-scale educational program to inform our patients and to increase the knowledge and skills of doctors of various specialties in order to control the greatest possible number of risk factors which lead to atherosclerosis, including chronic infection of the oral cavity.
About the Authors
E. N. AnisimovaRussian Federation
PhD, associate Professor, Department of anesthesia in dentistry o
Moscow
N. A. Ryazancev
Russian Federation
PhD, associate Professor, Department of anesthesia in dentistry
Moscow
A. A. Raskurajev
Russian Federation
PhD, researcher, neurologist
Moscow
M. M. Tanashyan
Russian Federation
PhD, MD, professor, Honored Scientist of the Russian Federation, head of department, deputy director for scientific work, head of the 1st neurological department (general angioneurology)
Moscow
M. P. Philippova
Russian Federation
PhD, associate Professor, Department of internal medicine
Moscow
A. H. Sadulaev
Russian Federation
post-graduate student, staff member, Department of anesthesia in dentistry
Moscow
M. A. Labzenkova
Russian Federation
student, staff member, Department of anesthesia in dentistry
Moscow
References
1. A. I. Startseva, M. Yu. Shcherbakova, T. V. Weather. Risk factors for atherosclerosis. Pediatrics. Journal them. GN Speransky. 2005;(84)3:95. (In Russ.). http://pediatriajournal.ru/files/upload/mags/268/2005_3_1372.pdf.
2. A. A. Kuranov, M. S. Baleev, N. N. Mitrofanova, V. L. Melnikov. Some aspects of the pathogenesis of atherosclerosis and risk factors for the development of cardiovascular diseases. Journal of Fundamental Research. 2014;10:1234-1238. (In Russ.). https://elibrary.ru/item.asp?id=22633983.
3. D. I. Trukhan, L. Yu. Trukhan. Relationships of periodontal diseases and cardiovascular diseases. International Journal of Heart and Vascular Diseases. 2016;11. (In Russ.). https://elibrary.ru/item.asp?id=28407695.
4. B. F. Bradley, A. L. Doneen, D. J. Vigerust. High-risk periodontal pathogens contribute to the pathogenesis of atherosclerosis. Postgrad Medical Journal. 2017;93:215-220. http://dx.doi.org/10.1136/postgradmedj-2016-134279.
5. E. Gaetti-Jardim, S. L. Marcelino, C. R. Feitosa, G. A. Romito, M. J. Avila-Campos. Quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. Journal of Medical Microbiology. 2009;58. https://doi.org/10.1099/jmm.0.013383-0.
6. E. Figuero, M. Sanchez-Beltran, S. Cuesta-Frechoso, J. Marıa Tejerina, J. Antonio del Castro, Jose Marıa Gutierrez, D. Herrera, M. Sanz. Detection of Periodontal Bacteriain Atheromatous Plaque by Nested Polymerase Chain Reaction. Journal Periodontol. 2011;10. https://doi.org/10.1902/jop.2011.100719.
7. A. Pucar, J. Milasin, V. Lekovic, M. Vukadinovic, M. Ristic, S. Putnik, E. B. Kenney. Correlation between atherosclerosis and periodontal putative pathogenic bacterial infections in coronary and internal mammary arteries. Journal Periodontol. 2007;78(4):677-82. https://doi.org/10.1902/jop.2007.060062.
8. D. Taylor-Robinson, J. Aduse-Opoku, P. Sayed, J. M. Slaney, B. J. Thomas, M. A. Curtis. Oro-Dental Bacteria in Various Atherosclerotic Arteries. European Journal of Clinical Microbiology and Infectious Diseases. 2002;21:755-757. https://doi.org/10.1007/s10096-002-0810-5.
9. I. M. Velsko , S. S. Chukkapalli, M. F. Rivera, Ju-Youn Lee, H. Chen, D. Zheng, I. Bhattacharyya, P. R. Gangula, A. R. Lucas, L. Kesavalu. Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis. PLOS ONE. 2014;9(5). https://doi.org/10.1371/journal.pone.0097811.
10. T. Toyofuku, Y. Inoue, N. Kurihara, T. Kudo, M. Jibiki, N. Sugano, M. Umeda, Y. Izumi. Differential detection rate of periodontopathic bacteria in atherosclerosis. Surgery Today. 2011;41(10):1395-400. https://doi.org/10.1007/s00595-010-4496-5.
11. M. Szulc, W. Kustrzycki, D. Janczak, D. Michalowska, D. Baczynska, M. Radwan-Oczko. Presence of Periodontopathic Bacteria DNA in Atheromatous Plaques from Coronary and Carotid Arteries. BioMed Research International. 2015;ID825397. http://dx.doi.org/10.1155/2015/825397.
12. K. Ishihara , A. Nabuchi, R. Ito, K. Miyachi, H. K. Kuramitsu, K. Okuda. Correlation between Detection Rates of Periodontopathic Bacterial DNA in Carotid Coronary Stenotic Artery Plaque and in Dental Plaque Samples. JOURNAL Clinical Microbiology. 2004;42(11):5437. https://doi.org/10.1128/JCM.42.3.1313-1315.2004.
13. E. E. Ziganshina, D. M. Sharifullina, A. P. Lozhkin, R. N. Khayrullin, I. M. Ignatyev, A. M. Ziganshin. Bacterial Communities Associated with Atherosclerotic Plaques from Russian Individuals with Atherosclerosis. PLoS One. 2016;13;11(10):e0164836. https://doi.org/10.1371/journal.pone.0164836.
14. K. Nakano, H. Nemoto, R. Nomura, H. Inaba, H. Yoshioka, K. Taniguchi, A. Amano, T. Ooshima. Detection of oral bacteria in cardiovascular specimens. Oral Microbiology Immunology. 2009;Feb;24(1):64-8. https://doi.org/10.1111/j.1399-302X.2008.00479.x.
15. N. Kurihara, Y. Inoue, T. Iwai, M. Umeda, Y. Huang, I. Ishikawa. Detection and Localization of Periodontopathic Bacteria in Abdominal Aortic Aneurysms. European Journal Vascular Endovascular Surgery. 2004;28:553-558. https://doi.org/10.1016/j.ejvs.2004.08.010.
16. R. Rezzani, G. Favero, B. Buffoli, L. Fabrizio Rodella. Atherosclerosis and Periodontal Disease. 2016;25. https://smjournals.com/ebooks/atherosclerotic-cardiovascular-disease/chapters/ACD-16-07.pdf.
17. P. B. Lockhart, A. F. Bolger, P. N. Papapanou, O. Osinbowale, M. Trevisan, M. E. Levison, K. A. Taubert, J. W. Newburger, H. L. Gornik, M. H. Gewitz, W. R. Wilson, S. C. Smith, L. M. Baddour. Periodontal Disease and Atherosclerotic Vascular Disease: Does the Evidence Support an Independent Association. A Scientific Statement From the American Heart Association. 2012;May;22;125(20):2520-44. https://doi.org/10.1161/CIR.0b013e31825719f3.
18. Shuai Xu, Mingbao Song, Yu Xiong, Xi Liu, Yongming He, Zhexue Qin. The association between periodontal disease and the risk of myocardial infarction: a pooled analysis of observational studies. BMC Cardiovascular Disorders. 20174;(17):50. https://doi.org/10.1186/s12872-017-0480-y.
19. J. Budzyński, J. Wiśniewska, M. Ciecierski, A. Kędzia. Association between Bacterial Infection and Peripheral Vascular Disease: A Review. International Journal of Angiology. 2016;1(25). https://doi.org/10.1055/s-0035-1547385.
20. I. S. Dankevych-Kharchyshyn, O. M. Vynogradova, N. V. Malko, R. M. Gnid, A. P. Skalat, L. Y. Minko, O. I. Mrochko, Y. L. Bandrivsky, O. O. Bandrivska. Periodontal disease and Atherosclerosis (literature review). Wiadomosci Lekarskie. 2019;72(3):462-465. https://www.ncbi.nlm.nih.gov/pubmed/31050999.
21. P. N. Papapano. Relationship of periodontitis and atherosclerosis: actual information and significance for specialists and society. Attending physician 2013;7:44-49. (In Russ.). elibrary.ru/contents.asp?issueid=1346486.
22. A. I. Grudyanov, V. V. Ovchinnikova. The composition of the periodontal pathogenic microflora in people with periodontitis (different degrees of severity) according to the polymerase chain reaction. Dentistry. 2008;87;3:20-23. (In Russ.). https://elibrary.ru/item.asp?id=11517402
23. N. A. Volkova, L. A. Alekseeva, E. V. Dorofeeva, T. G. Makhovskaya, E. D. Dokina, N. V. Svistunova, N. V. Karpikova. Improving preventive measures in the context of cardiovascular diseases and their complications in a multidisciplinary clinic. Analytical Bulletin. 44(597). (In Russ.). http://council.gov.ru/media/files/vDAae8RlETGBbkLMUlOAkE2keXyvvYi5.pdf.
24. I. A. Gorbachev, L. Yu. Orekhova, L. A. Shestakova, O. V. Mikhailova. Connection of diseases of internal organs with inflammatory lesions of the oral cavity. Parodontologiya. 2009;3(53):3-7. (In Russ.). https://elibrary.ru/contents.asp?titleid=9334.
Review
For citations:
Anisimova EN, Ryazancev NA, Raskurajev AA, Tanashyan MM, Philippova MP, Sadulaev AH, Labzenkova MA. The relationship of inflammatory diseases in the oral cavity and cardiovascular system. Literature review and determining the level of dental education. Parodontologiya. 2019;24(4):301-307. (In Russ.) https://doi.org/10.33925/1683-3759-2019-24-4-301-307