Risk factors for the progression of chronic generalized periodontitis in women during menopause
https://doi.org/10.33925/1683-3759-2020-25-3-201-205
Abstract
Relevance. The global trend associated with increasing life expectancy leads to an augmentation of the frequency of diseases and conditions associated with the cessation of estrogen production. Hormonal changes in the female body, which lead to changes in the mineral density of bone tissue, microcirculation, and immune status, create prerequisites for the destruction of target organs, including periodontal tissues. The highest prevalence of periodontal pathology is observed against the background of estrogen deficiency, especially during menopause. The multifactorial nature of the Association of pathologies that develop against the background of estrogen deficiency requires further study.
Purpose. Assessment of the contribution of various pathogenetic factors to the progression of oral pathology in women in the period of reproductive aging.
Materials and methods. The paper uses the results obtained during the examination of 73 patients with chronic generalized periodontitis at various stages of menopause with an assessment of the level of reproductive hormones, endothelial dysfunction, major periodontogens, and local immunity.
Results. An increase in the duration of menopause leads to the formation of endothelial dysfunction, increased destruction of periodontal bone tissue, and local immunosuppression.
Conclusion. The progression of periodontal diseases in menopause depends on many factors, including estrogen deficiency, violations of local and general blood supply, immunity disorders and microbial flora.
About the Authors
L. Yu. Ostrovskaya
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Ostrovskaya Larisa Yu., PhD, Md, DSc, Professor of the department of Therapeutical Stomatology.
SaratovA. V. Lepilin
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Lepilin Alexander V. - PhD, Md, DSc, Professor, chief of the department of surgical dentistry and maxillofacial surgery.
SaratovN. L. Erokina
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Erokina Nadezhda L. - PhD, Md, DSc, Professor of the department of surgical dentistry and maxillofacial surgery.
SaratovL. S. Katkhanova
Saratov State Medical University named after V.I. Razumovsky
Russian Federation
Russian Federation
Katkhanova Lilia S. - MD of the department of Therapeutical Stomatology.
SaratovS. B. Fischev
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
Fishchev Sergey B. - PhD, Md, DSc, Professor, chief of the department of pediatric dentistry and orthodontics.
Saint-PetersburgReferences
1. L. Yu. Orekhova, E. S. Loboda, N. A. Yamanidze. Improving the methods for the diagnosis and treatment of periodontal inflammatory diseases using various forms of medical ozone, by evaluating the microcirculation of periodontal tissues. Periodontology. 2018;23(1):58-63. (In Russ.). https://doi.org/10.25636/PMP.1.2018.1.13.
2. V. G. Atrushkevich, L. Y. Orekhova, O. O. Yanushevich, E. Y. Sokolova, E. S. Loboda. Optimization of the terms of supportive periodontal therapy using photoactivated disinfection. Periodontology. 2019;24(2):121-126. (In Russ.). https://doi.org/10.33925/1683-3759-2019-24-2-121-126.
3. A. A. Aleksandrova, L. Yu. Orekhova, L. A. Aleksandrova, R. S. Musaeva, E. V. Posokhova. An individual approach in development of oral hygiene complex for pregnant women with diabetes mellitus. Periodontology. 2017;22(2):33-39. (In Russ.). https://www.parodont.ru/jour/article/view/143.
4. A. V. Lepilin, N. V. Bulkina, L. Yu. Ostrovskaya, Yu. L. Osipova, V. V. Masumova, N. L. Erokina. Inflammatory periodontal diseases with helicobacter pylori-associated gastroduodenal pathology (clinical-morphological and immunohistochemical examination). Russian Dental Journal. 2008;2:31-34. (In Russ.). https://elibrary.ru/item.asp?id=11576109.
5. V. F. Kirichuk, V. Yu. Shirokov, N. L. Erokina, S. G. Goloseev, T. V. Govorunova. The microcirculatory component of the hemostasis system in patients with chronic generalized periodontitis in combination with diseases of the gastroduodenal region and its dynamics during combined UHF therapy. Periodontology. 2005;1:21-25. https://elibrary.ru/item.asp?id=9483481.
6. A. V. Lepilin, N. L. Erokina, V. A. Titorenko, L. Yu. Ostrovskaya, H. U. Bisultanov. The state of periodontal tissues in patients with fractures of the lower jaw in combination with inflammatory periodontal diseases in the dynamics of treatment Saratov Journal of Medical Scientific Research. 2008;1:115-118. (In Russ.). https://elibrary.ru/item.asp?id=10209115.
7. E. Yamashita-Mikami, M. Tanaka, N. Sakurai, Y. Arai, A. Matsuo, H. Ohshima, S. Nomura, S. Ejiri. Correlations between alveolar bone microstructure and bone turnover markers in pre and post-menopausal women. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013;115(4):e12-9. https://doi.org/10.1016/j.oooo.2011.10.028.
8. B. C. Lopez, M. G. Perez, Y. J. Soriano. Dental considerations in pregnancy and menopause. J Clin Exp Dent. 2011;3:135–144. https://doi.org/10.4317/jced.3.e135.
9. G. A. Scardina, P. Messina. Oral microcirculation in post-menopause: a possible correlation with periodontitis. Gerodontology. 2012;29(2):e1045-1051. https://doi.org/10.1111/j.1741-2358.2011.00608.x.
10. G. Hajishengallis. Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response. Trends Immunol. 2014;35(1):3-11. http://dx.doi.org/10.1016/j.it.2013.09.001.
11. A. Wilensky, H. Segev, G. Mizraji, Y. Shaul, T. Capucha, M. Shacham, A-H. Hovav. Dendritic cells and their role in periodontal disease. Oral Diseases. 2014;20(2):119-126. http://dx.doi.org/10.1111/odi.12122.
12. L. Tarkkila, K. Kari, J. Furuholm, A. Tiitinen, J. H. Meurman. Periodontal disease-associated microorganisms in peri-menopausal and post-menopausal women using or not using hormone replacement therapy. A twoyear follow-up study. BMC Oral Health. 2010;10:10. https://doi.org/10.1186/1472-6831-10-10.
13. A. N. Haas, C. K. Rosing, R. V. Oppermann, J. M. Albandar, C. Susin. Association among menopause, hormone replacement therapy, and periodontal attachment loss in southern Brazilian women. J. of Periodontology. 2009;80(9):1380-1387. http://doi.org/10.1902/jop.2009.090082.
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For citations:
Ostrovskaya LY, Lepilin AV, Erokina NL, Katkhanova LS, Fischev SB. Risk factors for the progression of chronic generalized periodontitis in women during menopause. Parodontologiya. 2020;25(3):201-205. (In Russ.) https://doi.org/10.33925/1683-3759-2020-25-3-201-205
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