Clinical and biochemical parameters of the effectiveness a periodontal probiotic complex
E. V. Brusnitsyna,
T. V. Zakirov,
I. V. Gavrilov,
L. A. Kaminskaya,
A. S. Prikhodkin,
G. D. Savchenko,
E. S. Beda https://doi.org/10.33925/1683-3759-2020-25-3-225-230
Abstract
Relevance. The article describes the use of probiotics in dentistry. This is a possible alternative to antibiotic therapy for major periodontal diseases. The efficacy of the probiotic complex «ASEPTA PARODONTAL®» containing Lactobacillus plantarum, Lactobacillus brevis, vitamin D was studied in the gingivitis treatment.
Purpose. To prove use of the probiotic complex in patients with gingivitis.
Materials and methods. An open comparative study of the use the probiotic complex «ASEPTA PARODONTAL®» for a month was conducted, in which 37 volunteers took part, with an average age of 21.3 ± 1.0 years.
Results. After a month of using the medicine, a decrease in the hygiene index by 38,19 % and the inflammation index PMA by 46,65% were revealed. The decrease of index SBI was 63,47 %, the decrease the level of halitosis on the VAS scale was 66,23%. The biochemical indicators of saliva revealed a decrease in GOT from 22,25 ± 4,06 U/l to 7,36 ± 1,24 U/l, GPT from 14,26 ± 2,61 to 4,67 ± 1,08 U/l, saliva protein level by 70,28% to 0,63 ± 0.10 g/l, a decrease in the integral index of total antioxidant activity from 1,15 ± 0,04 to 0,81 ± 0,05 mmol/l.
Conclusion. The probiotic complex «ASEPTA PARODONTAL®» has anti-inflammatory effect and reduces the level of halitosis. The studied complex normalizes the biochemical parameters of saliva, characterizing the change in the microbiota of the oral cavity.
About the Authors
E. V. Brusnitsyna
Ural State Medical University
Russian Federation
Russian Federation
Brusnitsyna Elena V. - PhD, Assistant of the Department of Children's Dentistry and Ortodontics.
Ekaterinburg
T. V. Zakirov
Ural State Medical University
Russian Federation
Russian Federation
Zakirov Taras V. - PhD, Associate Professor of the Department of Children's Dentistry and Ortodontics.
Ekaterinburg
I. V. Gavrilov
Ural State Medical University
Russian Federation
Russian Federation
Gavrilov Ilia V., PhD, Associate Professor of the Department of biochemistry.
Ekaterinburg
L. A. Kaminskaya
Ural State Medical University
Russian Federation
Russian Federation
Kaminskaya Ludmila A., PhD, Associate Professor of the Department of biochemistry.
Ekaterinburg
A. S. Prikhodkin
Ural State Medical University
Russian Federation
Russian Federation
Prikhodkin Artem S. - student.
EkaterinburgG. D. Savchenko
Ural Federal University
Russian Federation
Russian Federation
Savchenko Gleb D. - fifth year student of Biology Faculty.
Ekaterinburg
E. S. Beda
Ural Federal University
Russian Federation
Russian Federation
Beda Elizaveta S., fifth year student of Biology Faculty.
Ekaterinburg
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Review
For citations:
Brusnitsyna EV, Zakirov TV, Gavrilov IV, Kaminskaya LA, Prikhodkin AS, Savchenko GD, Beda ES. Clinical and biochemical parameters of the effectiveness a periodontal probiotic complex. Parodontologiya. 2020;25(3):225-230. (In Russ.) https://doi.org/10.33925/1683-3759-2020-25-3-225-230
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