Current antibiotic therapy of endo-perio lesions with secondary endodontic involvement
https://doi.org/10.33925/1683-3759-2021-26-2-105-113
Abstract
Relevance. Successful treatment of endo-perio lesions depends on the thorough clinical assessment, accurate diagnosis and structural approach to the planning of periodontal and endodontic treatment. Aim – to provide clinical and laboratory evidence about the effectiveness of ciprofloxacin-and-tinidazole-containing antibiotic in the comprehensive treatment of endo-perio lesions with a primary periodontal disease which secondarily affects the pulp.
Materials and methods. We examined 29 patients aged from 35 to 50 (mean age 42.3±3.21) with class II endo-perio lesions according to P. Eickholz classification. The patients were randomly divided into 2 groups. All patients had comprehensive periodontal and endodontic treatment with (Group 2) and without (Group 1) antibiotic therapy. The clinical and paraclinical examination included determination of such indices as OHI-s, SL, PMA, SBI, as well as Doppler ultrasound, EPT, CBCT, microbiological test of the discharge from periodontal pockets and root canal system. We selected the systemic antibiotic after the antibiotic sensitivity testing.
Results. Comprehensive treatment of endo-perio lesions, which included systemic antibiotic therapy with ciprofloxacin and tinidazole, effectively arrested the inflammation in the periodontium and pulp beginning from the 7th day of use.
Conclusion. Cifran ST, a combination broad-spectrum antibiotic, helps reduce periodontal inflammation by effectively eliminating microbiota in the root canals and periodontal pockets in patients with moderate or severe chronic generalized periodontitis.
About the Authors
L. Yu. Orekhova
First St. Petersburg State Medical University named after I.P. Pavlov;
«PAKS» City Periodontal Center, LLC
Russian Federation
Russian Federation
Liudmila Yu. Orekhova, Dr. Sci. (Med.), Professor, Chief of the Department of Therapeutic Dentistry and Periodontology; President of the Russian Periodontological Association (RPA)
Saint Petersburg
V. G. Atrushkevitch
Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Victoria G. Atrushkevich, Dr. Sci. (Med.), Professor of the Department of periodontology; Vice-President of the Russian Periodontological Association (RPA)
Moscow
E. S. Loboda
First St. Petersburg State Medical University named after I.P. Pavlov;
«PAKS» City Periodontal Center, LLC
Russian Federation
Russian Federation
Ekaterina S. Loboda, PhD, Associate Professor of the Department Operative Dentistry and Periodontology; dentist at "PAKS" City Periodontal Center Ltd.
Saint Petersburg
V. Yu. Vashneva
First St. Petersburg State Medical University named after I.P. Pavlov
Russian Federation
Russian Federation
Veronica Yu. Vashneva, PhD, Associate Professor of the Department Operative Dentistry and Periodontology
Saint Petersburg
A. A. Petrov
First St. Petersburg State Medical University named after I.P. Pavlov
Russian Federation
Russian Federation
Alexander A. Petrov, Postgraduate student of the Department of Operative Dentistry and Periodontology
Saint Petersburg
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Review
For citations:
Orekhova LY, Atrushkevitch VG, Loboda ES, Vashneva VY, Petrov AA. Current antibiotic therapy of endo-perio lesions with secondary endodontic involvement. Parodontologiya. 2021;26(2):105-113. (In Russ.) https://doi.org/10.33925/1683-3759-2021-26-2-105-113
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