Study of the anti-inflammatory properties of preventive toothpaste

Relevance. An essential component of the treatment and prevention of periodontal diseases is regular individual oral hygiene. Educating patients on effective hygiene practices using toothpaste with anti-inflammatory properties can significantly reduce gingivitis symptoms. Our study evaluated the impact of toothpaste containing octadecafluorodecahydronaphthalene on periodontal tissues among international students who experienced a change in residence.

Material and methods. Over 10 days, we observed a group of 26 international students studying at Kirov State Medical University, who used toothpaste containing perfluorodecalin and identical toothbrushes twice daily. The study included index assessments (OHI-S, PMA), as well as microbiological and biochemical analyses. Descriptive and analytical statistical methods were employed.

Results. Positive clinical dynamics were observed, with reductions in OHI-S and PMA indices. There was a decrease in the total microbial count and specific types of periodontopathogenic microorganisms. Additionally, clinical improvement in periodontal tissue condition (gingival mucosa) was noted, attributed to the effects of perfluorinated compounds on periodontal microcirculation. The product's anti-plaque and anti-inflammatory effects were confirmed through clinical, microbiological, and biochemical methods.

Conclusion. Daily use of toothpaste with octadecafluorodecahydronaphthalene (perfluorodecalin) had a beneficial effect on the condition of periodontal tissues, reducing inflammation by altering the microbiota structure within the biofilm and decreasing the number of periodontopathogenic microorganisms.

1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366(9499):1809-1820. doi: 10.1016/S0140-6736(05)67728-8

2. Kuzmina EM, Yanushevich OO, Kuzmina IN, Lapatina AV. Tendency in the prevalence of dental caries among the Russian population over a 20-year period. Dental Forum. 2020;(3):2-8. (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=43825063

3. Kaysina TN, Guzhavina NA, Mal’tzeva OA, Gromova SN, Tolmacheva II, Medvedeva MS, Khalyavina IN. Comparative characteristics of dental status оf the population of Kirov and the Russian Federation оf different age groups. Medical newsletter of vyatka. 2023;(2):85-88. doi: 10.24412/2220-7880-2023-2-85-88

4. Tsakoeva AA, Daurova FY, Kicha DI. Periodontal condition at the medic-students from South-East Asia. Parodontologiya. 2008;(3):75-78 (In Russ.). Available from: https://elibrary.ru/item.asp?id=11636747

5. Kodzaeva ZS, Daurova FU. Oral health status among foreign students of Peoples’ Friendship University of Russia from different regions of the world. Russian Journal of Dentistry. 2012;16(4):58-62 (In Russ.). Available from: https://rjdentistry.com/1728-2802/article/view/39116/26012

6. Neupane SP, Virtej A, Myhren LE, Bull VH. Biomarkers common for inflammatory periodontal disease and depression: A systematic review. Brain Behav Immun Health. 2022;21:100450. doi: 10.1016/j.bbih.2022.100450

7. Daurova FU. Complex program of dental diseases prevention and treatment among foreign students of Peoples’ Friendship University of Russia. Russian Journal of Dentistry. 2012;16(4):54-58 (In Russ.). Available from: https://rjdentistry.com/1728-2802/article/view/39111/26007

8. Usenko LV, Tsarev AV. Blood substitutes with gas transport function: hope and realties. Emergency medicine. 2018;(1):9-18. (In Russ.). Available from: https://elibrary.ru/item.asp?id=32660631

9. Dronov EB. Pharmaco-economic analysis of the application of perftoran and ascorbic acid in the treatment of patients with acute pancreatitis. Al'manah molodoj nauki. 2014;(4):35-39 (In Russ.). Available from: https://elibrary.ru/item.asp?id=23447838

10. Spahn DR. Blood substitutes. Artificial oxygen carriers: perfluorocarbon emulsions. Crit Care. 1999;3(5):93-97. doi: 10.1186/cc364

11. Khamad Z, Rasulov KM, Gadzhiev MG, Magomedov MА. Microcirculatory disorders in experimental mild periodontitis and treatment by perftoranum. Fundamental Research. 2004;(4):88-89. (In Russ.). Available from: https://fundamental-research.ru/ru/article/view?id=5459

12. Musalov KMG, Magomedov MA, Osmanova AA, Magomedov KM. Morphological assessment of tissue repair in complex with perftoran chronic relapsing crack lips in the experiment. Endodontics Today. 2017;15(2):62-66 (In Russ.). Available from: https://www.endodont.ru/jour/article/view/71/73

13. Kislykh FI, Komlev VV, Vlasova OS, Shvyleva OS, Snurnitsina ZA. Improvement of methods of treatment of inflammatory maxillofacial area deaseases using perphtoran. Perm Medical Journal. 2006;23(4):95-104 (In Russ.). Available from: https://elibrary.ru/item.asp?id=15100617

14. Orlov AA, Carmen NB, Marinicheva IG, Petrova IN, Ippolitov VP, Mayevsky EI. Correction of the regional blood flow by perftoran in patients with maxillofacial deformations. Russin Journal of Dentistry. 2004;(3):14-16 (In Russ.). Available from: https://elibrary.ru/ggnhck

15. Moroz VV. Kirsanova AK, Novoderzhkina IS, Aleksandrin VV, Nazarova GA. Membrane-Protecting Effects of Perfluorane on Red Blood Cells in Acute Blood Loss (an experimental study). General Reanimatology. 2011;7(1):5 (In Russ.) doi: 10.15360/1813-9779-2011-1-5

16. Orlov AA, Grigoryan AS, Marinicheva IG, Ippolitov VP, Carmen NB, Mayevsky EI. Perftoran in healing of soft and osseous tissues in rats. Russian journal of Dentistry. 2004;3:69 (In Russ.). Available from: https://elibrary.ru/okjwkj

17. Durnovo EA, Bespalova NA, Vorobjeva AV. Clinical estimation of Perftoran local effect periodontal tissues healing at postoperation period. Parodontologiya. 2010;1(54):61-64 (In Russ.). Available from: https://elibrary.ru/item.asp?id=15244683

18. Bel’skaya LV, Sarf EA, Kosenok VK, Massard Zh. Antioxidant activity of human mixed saliva in norm. Human Ecology. 2017;24(6):36-40 (In Russ.). doi: 10.33396/1728-0869-2017-6-36-40

19. Leontyev VK, Ivanova GG. Methods of investigating the oral fluid and the state of dental hard tissues (review). The Dental Institute. 2013;(4):86-88 (In Russ.). Available from: https://elibrary.ru/item.asp?id=22988431

20. Sokolova KV, Voynova AV, Elikov AV, Tsapok PI. Influence of diabetogenic factors on biochemical parameters of mixed saliva. Medical education today. 2018;(3):14-26 (In Russ.). Available from: https://medobrtoday.ru/index.php/medobrtoday/issue/view/4/№3%202018

21. Tsarev VN, Nikolaeva EN, Ippolitov EV. Periodontophatogenic bacteria of the main factors of emergence and development of periodontitis. Journal of Microbiology, Epidemiology and Immunobiology. 2017;94(5):101-112 (In Russ.). Available from: https://microbiol.crie.ru/jour/article/view/214/323

22. Tamarova ER, Masagutova NR. Molecular genetic characteristics of the oral microflora in periodontitis. Bulletin of Chelyabinsk State University. 2013;(7):70-71 (In Russ.). Available from: https://elibrary.ru/item.asp?id=18958119

23. Glushanova NA. Biological properties of lactobacillus. Bulletin of Siberian Medicine. 2003;2(4):50-58 (In Russ.). doi: 10.20538/1682-0363-2003-4-50-58