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Study of the anti-inflammatory properties of preventive toothpaste

https://doi.org/10.33925/1683-3759-2024-950

Abstract

Relevance. An essential component of the treatment and prevention of periodontal diseases is regular individual oral hygiene. Educating patients on effective hygiene practices using toothpaste with anti-inflammatory properties can significantly reduce gingivitis symptoms. Our study evaluated the impact of toothpaste containing octadecafluorodecahydronaphthalene on periodontal tissues among international students who experienced a change in residence.

Material and methods. Over 10 days, we observed a group of 26 international students studying at Kirov State Medical University, who used toothpaste containing perfluorodecalin and identical toothbrushes twice daily. The study included index assessments (OHI-S, PMA), as well as microbiological and biochemical analyses. Descriptive and analytical statistical methods were employed.

Results. Positive clinical dynamics were observed, with reductions in OHI-S and PMA indices. There was a decrease in the total microbial count and specific types of periodontopathogenic microorganisms. Additionally, clinical improvement in periodontal tissue condition (gingival mucosa) was noted, attributed to the effects of perfluorinated compounds on periodontal microcirculation. The product's anti-plaque and anti-inflammatory effects were confirmed through clinical, microbiological, and biochemical methods.

Conclusion. Daily use of toothpaste with octadecafluorodecahydronaphthalene (perfluorodecalin) had a beneficial effect on the condition of periodontal tissues, reducing inflammation by altering the microbiota structure within the biofilm and decreasing the number of periodontopathogenic microorganisms.

About the Authors

S. N. Gromova
Kirov State Medical University
Russian Federation

Svetlana N. Gromova, DMD, PhD, Dean, Head of the Department of Dentistry

Kirov



E. P. Kolevatich
Kirov State Medical University
Russian Federation

Ekaterina P. Kolevatykh, MD PhD, Head of the Department of Microbiology and Virology

Kirov



A. V. Elikov
Kirov State Medical University
Russian Federation

Anton V. Elikov, MD, PhD, Associate Professor, Department of the Chemistry

Kirov



M. S. Medvedeva
Kirov State Medical University
Russian Federation

Maria S. Medvedeva, DMD, Assistant Professor, Department of the Dentistry

Kirov



B. A. Kreneva
Kirov State Medical University
Russian Federation

Victoria A. Kreneva, DMD, Senior Lecturer, Department of the Dentistry

Kirov



А. А. Sychugova
Kirov State Medical University
Russian Federation

Alina A. Sychugova, 4th year Student, Dental School, Department of the Dentistry

Kirov



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Supplementary files

Review

For citations:


Gromova SN, Kolevatich EP, Elikov AV, Medvedeva MS, Kreneva BA, Sychugova АА. Study of the anti-inflammatory properties of preventive toothpaste. Parodontologiya. 2024;29(2):225-234. (In Russ.) https://doi.org/10.33925/1683-3759-2024-950

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ISSN 1683-3759 (Print)
ISSN 1726-7269 (Online)