Cicatricial pemphigoid (Lortat-Jacob disease) with oral manifestations: clinical case descriptions
https://doi.org/10.33925/1683-3759-2025-1082
Abstract
Relevance. Cicatricial pemphigoid (Lortat-Jacob disease, ICD-10 code L12.1) is a rare chronic autoimmune disorder characterized by the formation of subepithelial blisters and erosions on mucous membranes, typically leading to scarring. Since the oral mucosa may serve as the initial site of manifestation, the dentist plays a critical role in the early identification and comprehensive management of this condition
Clinical case description. This article presents two clinical cases of cicatricial pemphigoid (Lortat-Jacob disease). In the male patient, lesions were localized on the oral mucosa and manifested as erosions on the gingiva, soft palate, and vestibular fold. In the female patient, erosions were observed on the soft and hard palate and the alveolar ridge. Due to ocular involvement, both patients required care not only from a dermatologist but also from an ophthalmologist.
Conclusion. Limited awareness of this condition, the variability of its clinical manifestations, and the potential for severe complications highlight the need for interdisciplinary collaboration to ensure early recognition and timely treatment.
Supporting agencies: The authors declare that there was no external funding for the study.
About the Authors
E. A. Volkov
Russian University of Medicine
Russian Federation
Russian Federation
Evgeny A. Volkov, DMD, Professor, Department of the Restorative Dentistry and Periodontology
Moscow
O. M. Vasyukova
Russian University of Medicine
Russian Federation
Russian Federation
Olga M. Vasyukova, DMD, PhD, Docent, Assistant Professor, Department of the Restorative Dentistry and Periodontics
4 Dolgorukovskaya Str., Moscow, 127006
E. S. Slazhneva
Russian University of Medicine
Russian Federation
Russian Federation
Ekaterina S. Slazhneva, DMD, PhD, Associate Professor, Department of the Restorative Dentistry and Periodontology
Moscow
O. A. Bazikyan
Russian University of Medicine
Russian Federation
Russian Federation
Olga A. Bazikyan, DMD, PhD, Associate Professor, Department of the Oral Surgery and Implantology, Vice-President of RPA
Moscow
V. G. Atrushkevich
Russian University of Medicine
Russian Federation
Russian Federation
Victoria G. Atrushkevich, DMD, PhD, DSc, Professor, Head of the Department of Restorative Dentistry and Periodontology, Vice-President of RPA
Moscow
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Review
For citations:
Volkov EA, Vasyukova OM, Slazhneva ES, Bazikyan OA, Atrushkevich VG. Cicatricial pemphigoid (Lortat-Jacob disease) with oral manifestations: clinical case descriptions. Parodontologiya. 2025;30(1):86-93. (In Russ.) https://doi.org/10.33925/1683-3759-2025-1082
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