Modern concept of polarization of macrophages and its importance for periodontology (literature review)
https://doi.org/10.25636/PMP.1.2018.3.11
Abstract
In periodontology, the plasmolifting technique is successfully used, based on the use of platelet-enriched autoplasm. Another promising method for the treatment of inflammatory periodontal diseases is programming of macrophages. The review analyzed information on the ability of tissue macrophages under the influence of environmental stimuli to acquire different phenotypes, including the classical M1 and the alternative M2. The first of them produces pro-inflammatory factors and promotes the development of an inflammatory reaction. The M2 phenotype produces anti-inflammatory factors and stimulates reparative processes in the tissue. A technique for reprogramming macrophages with a view to obtaining a therapeutic effect is described, the mechanism of its action.
About the Authors
V. A. Rumyantsev
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
Sh. L. Shimansky
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
E. I. Budashova
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
Yu. I. Yusupova
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
V. S. Afonenkova
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
D. A. Moiseyev
ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Rumyantsev VA, Shimansky SL, Budashova EI, Yusupova YI, Afonenkova VS, Moiseyev DA. Modern concept of polarization of macrophages and its importance for periodontology (literature review). Parodontologiya. 2018;24(3):64-69. (In Russ.) https://doi.org/10.25636/PMP.1.2018.3.11
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