Evaluation of enzyme systems gums on a background of application of mildronate in experimental periodontitis
https://doi.org/10.25636/PMP.1.2018.3.12
Abstract
A histochemical analysis of the state of enzyme systems of the gum in experimental periodontitis with the use of mildro-natewere presented.10-20 days after the formation of the periodontitis model in rats, the activity of alkaline and acid phosphatases, lipoamide dehydrogenase and nonspecific AS-esterase increases in the background of systemic application of mildronate in the gingival tissues, and the activity of lactate dehydrogenase and succinate dehydrogenase decreases.In later terms (40-60 days), the use of the drug almost does not change the activity of acidic and alkaline phosphatases. In contrast to the control, in the late period of periodontitis development, mildronate reduces the activity of lactate dehydrogenase, lipoamide dehydrogenase and nonspecific AS-esterase, the most significant being a decrease in the activity of the isoenzyme fractions of lactate dehydrogenase-3 and AS-esterase-1.
About the Authors
S. V. Sirak
ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
E. V. Shchetinin
ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
N. I. Bykova
ФГБОУ ВО «Кубанский государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
A. G. Tarabrina
ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
R. G. Romanenko
ФГБОУ ВО «Ставропольский государственный медицинский университет» Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Sirak SV, Shchetinin EV, Bykova NI, Tarabrina AG, Romanenko RG. Evaluation of enzyme systems gums on a background of application of mildronate in experimental periodontitis. Parodontologiya. 2018;24(3):70-74. (In Russ.) https://doi.org/10.25636/PMP.1.2018.3.12
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