The influence of bile acids on the mucous membranes of the oral cavity in rats in the experiment

Abstract

The article presents the results of the analysis of biochemical changes occurring in the oral mucosa in rats under the influence of bile acid.

The experiment was carried out on 18 male rats of Wistar line. The 1st (control) group included intact animals, the 2nd group carried out applications of litholic acid to the oral mucosa in the form of a gel (1 mg/ml CMC, 2.5%) for 4 hours, in the 3rd-24 hours.

It is established that the application of bile acid causes inflammatory processes in the oral mucosa. In this case, there is a decrease in the level of MDA (p>0.05, p>0.05), accompanied by a significant increase in the activity of the antioxidant enzyme catalase (p>0.05, p<0.05).

The digital values of the API index after application of lithocholic acid significantly increased in all periods of study (p>0.05, p<0.001). Its local effect affects the General somatic status, as evidenced by a significant increase in serum of one of the biochemical markers of inflammation — elastase activity (p>0.05, p<0.05).

Our studies indicate the dual nature of the effects of bile acids on the oral mucous membrane. On the one hand, they activate several inflammatory processes, and on the other, induce activation of protective systems, in this case, the antioxidant system.