Dynamics of indicators of reparative regeneration of the oral mucosa in patients with lichen planus

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite difficult to differentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic effects that help accelerate the healing of the oral mucosa.

Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.

Materials and methods: all patients were divided into two groups using simple randomization: in patients of the first group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a film, which fixed betamethasone B in the lesion area.

Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.

Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.

1. S. V. Sirak, V. V. Chebotarev, A. G. Sirak, E. M. Kirzhinova, S. A. Khanova. Lichen planus of the oral mucosa: opportunities for local treatment against the background of general therapy. Periodontology. 2015;20(1):26-30. (In Russ.). https://elibrary.ru/item.asp?id=23413719.

2. Yu. A. Makedonova, I. V. Firsova, S. V. Poroisky. Evaluation of the parameters of the basal blood flow of the oral mucosa in patients with lichen planus against the background of local medical treatment. Periodontology. 2017;1(82):41-45. (In Russ.). https://elibrary.ru/ item.asp?id=29233672.

3. V. G. Solodkiy, M. V. Ovechkina. The use of autologous plasma platelet plasma in the practice of surgical dentistry. Periodontology. 2016;21(3):62-66. (In Russ.). https://elibrary.ru/item.asp?id=27185786.

4. A. I. Yaremenko, T. B. Tkachenko, L. Yu. Orekhova, A. V. Silin, M. I. Koreshkina. The algorithm of the use of nonsteroidal anti-inflammatory drugs in dental practice. Periodontology. 2016;3(80):47-52. (In Russ.). https://elibrary.ru/item.asp?id=27185783.

5. S .A. Khanova, S. V. Sirak, I. M. Bykov, A. G. Sirak. Clinical and biochemical aspects of local therapy of lichen planus of the oral mucosa. Periodontology. 2014;19(2):13-18. (In Russ.). https://elibrary.ru/item.asp?id=22135428.

6. L. A. Dmitrieva, N. A. Glybina, T. A. Glybina, Kh. Kh. Babaniyazov, E. V. Larionov, V. P. Tumanov, E.A. Ruzhitskaya. Experimental rationale for the use of a new antioxidant drug for treatment of erosive and ulcerative lesions. Periodontology. 2012;3(64):52-58. (In Russ.). https://elibrary.ru/item.asp?id=18258267.

7. A. V. Sevbitov, A.S. Nevdakh, V.V. Platonova A new approach to the treatment of traumatic erosive-ulcerative injuries of the oral mucosa in orthodontic patients. Periodontology. 2016;3:12-14. (In Russ.). https://elibrary.ru/item.asp?id=27185775

8. O. S. Gileva, S. V. Koshkin, T. V. Libik, E. A. Gorodilova, I. N. Khalyavina Periodontal aspects of diseases of the oral mucosa: lichen planus. Periodontology. 2017;22(3):9-14. (In Russ.). https://elibrary.ru/item.asp?id=30060549.

9. S. V. Poroiskiy, Yu. A. Makedonova, I. V. Firsova, A. V. Poroiskaya, N. N. Trigolos. Experimental morphologic study of reparative processes in erosive lesions of the oral mucosa. General Dentistry. 2018;66(4):5-9. https:// doi.org/10.5604/01.3001.0010.8761.

10. R. C. Page, J. A. Martin. Quantification of periodontal risk and disease severity and extent using the Oral Health Information Suite (OHIS). Periodontal Practice Today. 2007;4:163-180. https://perio.quintessenz.de/index. php?doc=pdf&abstractID=12634.