The value of vascular endothelial growth factor in patients with chronic generalized periodontitis associated metabolic syndrome
Abstract
Endothelial dysfunction (ED) is one of the key independent risk factors for the development of diabetes mellitus, inflammatory, autoimmune and tumoral diseases.
Purpose: to study the relationship between the expression of vascular endothelial factor and the number of desquamated endothelial cells in patients with chronic generalized periodontitis (CGP) associated insulin resistance syndrome.
14 practically healthy persons (control) and 72 patients with moderate BPH (24 patients without concomitant diseases, 48 patients with CHP in combination with MS) were examined. Immunoenzymatic methods were used to determine the number of desquamated cells and vascular endothelial growth factor in blood plasma.
In patients with CGP associated MS, an increase in the level of desquamated endothelial blood cells was revealed against a background of a significant increase in the vascular endothelial growth factor, which is caused by dysfunction of the carbohydrate, lipid and hormonal systems.
About the Authors
Zh. U. Abduvakilov
Ташкентский государственный стоматологический институт
Uzbekistan
Uzbekistan
Zh. A. Rizaev
Ташкентский государственный стоматологический институт
Uzbekistan
Uzbekistan
References
1. Abramova N. O., Pashkovskaja N. V. Harakteristika ekspressii sosudistogo endotelial’nogo faktora rosta i intensivnosti deskvamacii jendotelial’nyh kletok u pacientov s sindromom netireoidnoj patologii na fone arterial’noj gipertenzii i abdominal’nogo ozhirenija // Journal of clinical medicine of Kazakhstan. 2013. Vol. 4. №30. P. 37-41.
2. Barer G. M., Grigorjan K. R. Parodontit u bol’nyh saharnym diabetom pervogo tipa (obzor literatury) // Parodontologija. 2006. №2 (39). S. 6-10.
3. Gorbacheva I. A., Orehova Ju L., Shestakova L. A. Svjaz’ zabolevanij vnutrennih organov s vospalitel’nymi porazhenijami polosti rta // Parodontologija. 2009. №3 (53). S. 3-7.
4. Kovalenko L. V., Belova E. A. Sostojanie lipidnogo, uglevodnogo obmenov i endotelial’naja funkcija pri metabolicheskom sindrome // Vestnik KazNMU. 2013. №5 (1). S. 367-370.
5. Kovalenko L. V., Belova E. A., Verizhnikova L. N. Endotelial’naja disfunkcija i metabolicheskij sindrom // Vestnik SurGU. Medicina. 2013. №3 (17). S. 8-13.
6. Levin M. Ja., Fedosenko T D., Vasil’ev O. N. Kolichestvennyj i funkcional’nyj sostav sistemnogo i mestnogo immuniteta u pacientov s hronicheskim periodon-titami i parodontitami // Parodontologija. 2010. №4. S. 37-40.
7. Shljahto E. V., Berkovich O. A., Beljaeva O. D. Sovremennye predstavlenija o disfunkcii endotelija i metodah ee korrekcii pri ateroskleroze // Mezhdunarodnyj nevrologicheskij zhurnal. 2002. №3. S. 9-10.
8. Arimatsu K., Yamada H., Miyazawa H. et al. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota // Sci. Rep. 2014. Vol. 4. P. 4828.
9. Chen L., Wei B., Liu F. et al. Association of periodontal parameters with metabolic level and systemic inflammatory markers in patients with type-2 diabetes // J. Periodontol. 2010. Vol. 81. P 364-371.
10. Dandona P, Aljada A., Chaudhuri A. et al. Metabolic syn-drome: a comprehensive perspective based on interactions between obesity, diabetes and inflammation // Circulation. 2005. №1. P 1448-1454.
11. Garcia de la Torre N., Rubio M. A., Bordiu E. et al. Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines, and insulin // J. Clin. Endocrinol. Metab. 2008. Vol. 93 (11). P.4276-4281. 12. Tripolt N. J. et al. Short communication: Effect of supplementation with Lactobacillus caseiShirota on insulin sensitivity, p-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome — a pilot study // J Dairy Sci. 2013. Vol. 96 (1). P 89-95.
Review
For citations:
Abduvakilov ZU, Rizaev ZA. The value of vascular endothelial growth factor in patients with chronic generalized periodontitis associated metabolic syndrome. Parodontologiya. 2018;24(4):123-126. (In Russ.)
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