Relevance of non-steroidal anti-inflammatory drugs in periodontology
https://doi.org/10.33925/1683-3759-2021-26-3-211-222
Abstract
Relevance. Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed in dental practice to relieve pain and swelling. This study reviews information on NSAIDs, with a particular focus on those aspects that are relevant to the practice of dentistry.
Materials and methods. A systematic literature search was conducted, which included studies dating from 1970 to June 2021. The search in the electronic databases e-LIBRARY.ru, Embase, Pubmed and Medline identified the studies. Articles were reviewed by meeting the inclusion and non-inclusion criteria.
Results. Initially, the electronic search identified 589 studies. After reviewing the titles and abstracts, 69 potentially relevant studies were subject to full-text evaluation. Of these, 34 studies were excluded based on study design, research question, or lack of numerical data on all variables to be assessed in this study, so 35 studies with a detailed list of such data could be included in the quantitative comparison.
Conclusion. The use of non-steroidal anti-inflammatory drugs may alter the inflammatory response in the treatment of oral diseases. The conducted studies have brought up questions about the effectiveness and alternative ways of NSAID delivery in dentistry, namely, dispersible formulation.
About the Authors
L. Yu. Orekhova
Pavlov First Saint Petersburg State Medical University; «PAKS» City Periodontal Center
Russian Federation
Russian Federation
Liudmila Yu. Orekhova, DMD, PhD, DSc, Professor, Head of the Department of Operative Dentistry and Periodontology
Saint Petersburg
E. S. Loboda
Pavlov First Saint Petersburg State Medical University; «PAKS» City Periodontal Center
Russian Federation
Russian Federation
Ekaterina S. Loboda, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology
Saint Petersburg
V. G. Atrushkevich
A.I. Yevdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Victoria G. Atrushkevich, DMD, PhD, DSc, Professor, Department of periodontology
Moscow
E. V. Kosova
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Elena V. Kosova, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology
Saint Petersburg
V. Yu. Vashneva
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Veronica Yu. Vashneva, DMD, PhD, Associate Professor, Department of Operative Dentistry and Periodontology
Saint Petersburg
A. A. Petrov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
Alexander A. Petrov, DMD, PhD student, department of Operative Dentistry and Periodontology
Saint Petersburg
References
1. Wongrakpanich S, Wongrakpanich A, Melhado K, Rangaswami JA. Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. aging dis. 2018;9(1):143-150. doi: 10.14336/AD.2017.0306
2. Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of Cox 2 inhibition: therapeutic challenges and opportunities. J clin Invest. 2006;116(1):4-15. doi: 10.1172/JCI27291
3. Hernandez-Dıaz S, Lorenzo V, Rodrıguez GL. Non-steroidal anti-inflammatory drugs and the risk of acute myocardial infarction. Basic clin Pharmacol Toxicol. 2006;98(3):266-274. doi: 10.1111/j.1742-7843.2006.pto_302.x
4. McGettigan P, Henry D. Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclo-oxygenase. JaMa. 2006;296(13):1633-1644. doi: 10.1001/jama.296.13.jrv60011
5. McGettigan P, Henry D. Cardiovascular risk with non– steroidal anti–inflammatory drugs: systematic review of population–based controlled observational studies. PloS Med. 2011;8(9):e1001098. doi: 10.1371/journal.pmed.1001098
6. Scheiman JM., Hindley CE. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther. 2010;32(4):667-677. doi: 10.1016/j.clinthera.2010.04.009
7. Rostom A, Muir K, Dube C, Lanas A, Jolicoeur E, Tugwell P. of NSAID–related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and cox–2 inhibitors. drug healthcare Patient Safety. 2009;1:47-71. doi: 10.2147/dhps.s4334
8. Strand V. Are COX–2 inhibitors preferable to non–selective non–steroidal anti–inflammatory drugs in patients with risk of cardiovascular events taking low dose aspirin? lancet. 2007;370(9605):2138-2151. doi: 10.1016/S0140-6736(07)61909-6
9. Garcia Rodriguez L, Tacconelli S, Patrignani P. Role of dose potency in the prediction of risk of myocardial infarction associated with non–steroidal anti–inflammatory drugs in the general population. J am coll cardiol. 2008;52(20):1628-1636. doi: 10.1016/j.jacc.2008.08.041
10. Fokunang CN, Fokunang ET, Frederick K, Ngameni B, Ngadjui B. Overview of non-steroidal anti-inflammatory drugs (nsaids) in resource limited countries. MoJ Toxicol. 2018;4(1):5-13. doi: 10.15406/mojt.2018.04.00081
11. Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA., Bombardier C, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. lancet. 2013;382:769-79. doi: 10.1016/S0140-6736(13)60900-9
12. Bacchi S, Palumbo P, Sponta A, Coppolino MF. Clinical pharmacology of non-steroidal anti-inflammatory drugs: a review. antiinflamm antiallergy agents Med chem. 2012;11:52-64. doi: 10.2174/187152312803476255.
13. Birmingham B., Buvanendran A. Nonsteroidal antiinflammatory drugs, Acetaminophen, and COX-2 inhibitors. In: Turk DC, Argoff CE, Hurley RW, editors. Practical Management of Pain. Philadelphia: elsevier; 2014:553-568. doi: 10.5152/eurasianjmed.2018.0010
14. Zidar N, Odar K, Glavac D, Jerse M, Zupanc T, Stajer D. Cyclooxygenase in normal human tissues-is COX-1 really a constitutive isoform, and COX-2 an inducible isoform? J cell Mol Med. 2009;13:3753-63. doi: 10.1111/j.1582-4934.2008.00430.x
15. Consalvi S, Biava M, Poce G. COX inhibitors: a patent review (2011–2014). expert opin Ther Pat. 2015;25:1357-71. doi: 10.1517/13543776.2015.1090973.2015
16. Liu J, Gao H.Y, Wang XF. The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system. neural regen res. 2015;10:1892-6. doi: 10.4103/1673-5374.170325
17. Tsujimoto S, Kishina M, Koda M, Yamamoto M, Tanaka Y, Harada K, Yoshida Y, et al. Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related nonalcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ. Int J Mol Med. 2016;38:721-8. doi: 10.3892/ijmm.2016.2674
18. Lee CH, Yoo KY, Choi JH, et al. Cyclooxygenase-2 immunoreactivity and protein level in the gerbil hippocampus during normal aging. neurochem res. 2010;35:99-106. doi: 10.1007/s11064-009-0037-2
19. Yagami T, Koma H, Yamamoto Y. Pathophysiological roles of cyclooxygenases and prostaglandins in the central nervous system. Mol neurobiol. 2016;53:4754-71. doi: 10.1007/s12035-015-9355-3
20. Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochem Pharmacol. 2020;180:114147. doi:10.1016/j.bcp.2020.114147
21. Орехова ЛЮ, Шайда ЛП, Вашнева ВЮ, Сычева ЮА, Рахова ВН, Петров АА, Качалов АБ. Особенности применения нестероидных противовоспалительных препаратов при лечении осложнения кариеса у пациентов с сопутствующей соматической патологией. Эндодонтия Today. 2021;19(1):45-52. [Orekhova LYu, Shayda LP, Vashneva VYu, Sycheva YuA, Rakhova VN, Petrov AA, Kachalov AB. Peculiarities of non-steroidal anti-inflammatory drugs in the treatment of complicated caries in patients with concomitant somatic pathology. Endodontics Today. 2021;19(1):45-52. (In Russ.).] doi: 10.36377/1683-2981-2021-19-1-45-52
22. Könönen E, Gursoy M, Gursoy UK. Periodontitis: A Multifaceted Disease of Tooth-Supporting Tissues. J clin Med. 2019;8(8):1135. doi:10.3390/jcm8081135
23. Katusic ZS, Santhanam AV, He T. Vascular effects of prostacyclin: does activation of PPARδ play a role? Trends Pharmacol Sci. 2012;33(10):559-564. doi:10.1016/j.tips.2012.05.005
24. Yao C, Narumiya S. Prostaglandin-cytokine crosstalk in chronic inflammation. Br J Pharmacol. 2019;176(3):337-354. doi:10.1111/bph.14530
25. Dewhirst F, Moss D, Offenbacher S, Goodson J. Levels of prostaglandin E2, thromboxane, and prostacyclin in periodontal tissues. Journal of Periodontal research. 2006;18:156-163. doi: 10.1111/j.1600-0765.1983.tb00348.x
26. Weinberg E, Zeldich E, Weinreb M, Moses O, Nemcovsky C, Weinreb M. Prostaglandin E-2 Inhibits the Proliferation of Human Gingival Fibroblasts Via the EP2 Receptor and Epac. Journal of cellular biochemistry. 2009;108:207-215. doi: 10.1002/jcb.22242
27. Williams RC. Periodontal disease. N Engl J Med. 1990;322:373-382. doi: 10.1056/NEJM199002083220606
28. Golub LM, Suomalainen K, Sorsa T. Host modulation with tetracyclines and their chemically modified analogues. Curr Opin Dent. 1992;2:80-90. PMID: 1325849
29. Kantarci A, Hasturk H, Van Dyke TE. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000. 2006;40:144-163. doi: 10.1111/j.1600-0757.2005.00145.x
30. Ryan ME. Host modulation: conceptualization to clinical trials and integration into clinical practice. J. candian assoc. 2002;6:1-8. PMID: 12005373
31. Honibald EN., Mathew S, Padmanaban IJ., Sundaram E, Ramamoorthy RD. Perioceutics: Matrix metalloproteinase inhibitors as an adjunctive therapy for inflammatory periodontal disease. J Pharm Bioallied Sci. 2012;4:417-21. doi: 10.4103/0975-7406.100315
32. Ryan M.E. Nonsurgical approaches for the treatment of periodontal diseases. dent clin n am. 2005;49:611-636. doi:10.1016/j.cden.2005.03.010
33. Serhan CN. A search for endogenous mechanisms of anti-inflammation uncovers novel chemical mediators: missing links to resolution. histochem cell Biol. 2004;122:305-321. doi: 10.1007/s00418-004-0695-8
34. Salvi GE, Lang NP. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. curr Pharm des. 2005;11(14):1757-69. doi: 10.2174/1381612053764878. PMID: 15892673
35. Jeffcoat MK, Page R, Reddy M, Wannawisute A, Waite P, Palcanis K, Cogen R, et al. Use of Digital Radiography to Demonstrate the Potential of Naproxen as an Adjunct in the Treat- ment of Rapidly Progressive Periodontitis. Periodontal res. 1991; 26:415:421. doi: 10.1111/j.1600-0765.1991.tb01731.x
36. Waite IM, Saxton CA, Young A, Wagg BJ, Corbett M. The Periodontal Status of Subjects Receiving Nonsteroidal Antiinflammatory Drugs. Periodontal. res. 1981;16:100-108. doi:10.1111/j.1600-0765.1981.tb00953.x
37. Jeffcoat MK, Williams RC, Reddy MS, English R, Goldhaber P. Flurbiprofen Treatment of Human Periodontitis: Effect on Alveolar Bone Height and Metabolism. Periodontal. res. 1988;23:381-385. doi: 10.1111/j.1600-0765.1988.tb01617.x
38. Heasman PA, Seymour RA. An Association Be- tween Long-Term Nonsteroidal Antiinflammatory Drug Therapy and the Severity of Periodontal Dis- ease. J. clin. Periodontol. 1990.17:654-658.
39. Heasman PA, Ward A, Barrett AW, Seymour RA, Edwards G. Flurbiprofen in Human Crevicular Fluid Analyzed by High Performance Liquid Chromatography. J. Periodontal. res. 1990.25:88-92. doi:10.1111/j.1600-0765.1990.tb00897.x
40. Johnson RH, Armitage GC, Francisco C, Page RC. Assessment of the Efficacy of a Nonsteroidal Antiinflammatory Drug, Naprosyn®, in the Treatment of Gingivitis. J. Periodontal. res. 1990;25:230-235. doi: 10.1111/j.1600-0765.1990.tb00909.x
41. Del Puente. A, Shlossman M, Arevalo A, Knowler WC, Genco RJ. Relationship of Rheumatoid Arthritis and Periodontal Disease. J. dent. res.1988;2064 (Abstr.) doi: 10.1177/10454411930040020301
42. Heasman PA, Seymour RA. The Effect of a Systemically-administered Nonsteroidal Antiin- flammatory Drug (Flurbiprofen) on Experimental Gingivitis in Humans. clin. Periodontol. 1989;16:551-556. doi:10.1111/j.1600-051x.1994.tb00298.x
43. Lasfarques JJ, Saffar JL. Effect of Indomethacin on Bone Destruction During Experimental Periodontal Disease in the Hamster. Periodontal. res. 1983;18:110-117. doi:10.1111/j.1600-0765.1983.tb00342.x
44. Vogel RI, Copper SA, Schneider LG, Goteiner D. The Effects of Topical Steroidal and Systemic Non- steroidal Antiinflammatory Drugs on Experimental Gingivitis in Man. J. Periodontol. 1984;55:247-251. doi:10.1902/jop.1984.55.4.247
45. Su B, O'Connor JP. NSAID therapy effects on healing of bone, tendon, and the enthesis. J appl Physiol (1985). 2013;115(6):892-899. doi:10.1152/japplphysiol.00053.2013
46. Xie Y, Pan M, Gao Y, Zhang L, Ge W, Tang P. Dosedependent roles of aspirin and other non-steroidal anti-inflammatory drugs in abnormal bone remodeling and skeletal regeneration. cell Biosci. 2019;9:103. doi:10.1186/s13578-019-0369-9
47. Betancourt JW, Kupp LI, Jasper SJ, Farooqi OA. Efficacy of ibuprofen-hydrocodone for the treatment of postoperative pain after periodontal surgery. J Periodontol. 2004;75(6):872-876. doi: 10.1902/jop.2004.75.6.872
48. Srinivas M, Medaiah S, Girish S, Anil M, Pai J, Walvekar A. The effect of ketoprofen in chronic periodontitis: A clinical double-blind study. J Indian Soc Periodontol. 2011;15(3):255-259. doi:10.4103/0972-124X.85670
49. Winnett B, Tenenbaum HC, Ganss B, Jokstad A. Perioperative use of non-steroidal anti-inflammatory drugs might impair dental implant osseointegration. clin oral Implants res. 2016;27(2):1-7. doi: 10.1111/clr.12493
50. Williams RC, Jeffcoat MK, Howell TH, Rolla A, Stubbs D, Teoh KW, Reddy MS et al. Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol. 1989;60(9):485-90. doi: 10.1902/jop.1989.60.9.485
51. Zavarella MM, Gbemi O, Walters JD. Accumulation of non-steroidal anti-inflammatory drugs by gingival fibroblasts. J dent res. 2006;85(5):452-456. doi:10.1177/154405910608500511
52. Taiyeb ATB, Waite IM. The effect of systemic ibuprofen on gingival inflammation in humans. J clin Periodontol. 1993;20(10):723-8. doi: 10.1111/j.1600-051X.1993.tb00697.x
53. Sekino S, Ramberg P, Lindhe J. The effect of systemic administration of ibuprofen in the experimental gingivitis model. J clin Periodontol. 2005;32(2):182-187. doi: 10.1111/j.1600-051X.2005.00671.x
54. Hargreaves KM, Diogenes A, Teixeira FB. Treatment options: biological basis of regenerative endodontic procedures. J endod. 2013;39(3):30-43. doi: 10.1016/j.joen.2012.11.025
55. Zanjir M, Sgro A, Laghapour Lighvan N, Yarascavitch C, Shah P, Costa B, Azarpazhooh A. Efficacy and safety of post-operative medications in reducing pain following nonsurgical endodontic treatment: a systematic review and network meta-analysis. Journal of endodontics. 2020;46(10). doi:10.1016/j.joen.2020.07.002
56. Jorge-Araújo ACA., Bortoluzzi MC, Baratto-Filho F, Santos FA, Pochapski MT. Effect of Premedication with Anti-inflammatory Drugs on Post-Endodontic Pain: A Randomized Clinical Trial. Braz dent J. 2018;29(3):254-260. doi: 10.1590/0103-6440201801786.
57. Pochapski MT, Santos FA, de Andrade ED, Sydney GB. Effect of pretreatment dexamethasone on postendodontic pain. oral Surgery, oral Medicine, oral Pathology, oral radiology, and endodontics. 2009;108(5):790-795. doi:10.1016/j.tripleo.2009.05.014
58. Cheung R, Krishnaswami S, Kowalski K. Analgesic efficacy of celecoxib in postoperative oral surgery pain: a single-dose, two-cen- ter, randomized, double-blind, active- and placebo-controlled study. clin Ther. 2007;29:2498-2510. doi: 10.1016/j.clinthera.2007.12.008
59. Каратеев АЕ, Насонов ЕЛ, Ивашкин ВТ, Мартынов АИ, Яхно НН, Арутюнов ГП, Алексеева ЛИ. и др. Рациональное использование нестероидных противовоспалительных препаратов. клинические рекомендации. научно-практическая ревматология. 2018;56:1-29. [Karateev AE, Nasonov EL, Ivashkin VT, Martynov AI, Yakhno NN, Arutyunov GP, Alekseeva LI. et al. Rational use of nonsteroidal anti-inflammatory drugs. clinical guidelines. rheumatology Science and Practice. 2018;56:1-29. (In Russ.).] doi:10.14412/1995-4484-2018-1-29
60. Barden J, Derry S, McQuay HJ, Moore RA. Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults. cochrane database Syst rev. 2009 7;(4):CD007355. doi: 10.1002/14651858
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For citations:
Orekhova LY, Loboda ES, Atrushkevich VG, Kosova EV, Vashneva VY, Petrov AA. Relevance of non-steroidal anti-inflammatory drugs in periodontology. Parodontologiya. 2021;26(3):211-222. (In Russ.) https://doi.org/10.33925/1683-3759-2021-26-3-211-222
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