Hemostasis disorder as a cause of periodontitis in type II diabetic patients
https://doi.org/10.33925/1683-3759-2021-26-3-240-244
Abstract
Relevance. In type II diabetes mellitus, hyperglycemia contributes to the endothelial dysfunction. It leads to hypercoagulation and significant microcirculation disorders, which cause periodontal tissue ischemia and inflammation. The study aimed to determine hemostatic parameters of endothelial dysfunction and evaluate its role in the origin of periodontitis in type II diabetic patients.
Materials and methods. We examined 40 people aged 50-80 years with compensated type II diabetes mellitus and chronic generalized periodontitis of various severity during planned hospital admission. The control group consisted of 26 practically healthy people of comparable age and sex. We assessed blood on patient admission to the hospital.
Results. Type II diabetic patients with chronic generalized periodontitis demonstrated pronounced changes in endothelial function. Compared to the controls, the patients with moderate-severe periodontitis exhibited a statistically significant (p < 0.05) increase of D-dimer (10.5 times), factor XIIa (8.4 times), and von Willebrand factor (2 times) in the blood serum; the increase of fibrinogen by 64.8%, the elevation of INR and antiplasmin by 19.7% and 12.7% respectively, the decrease of antithrombin by 17%.
Conclusion. The study confirms that type II diabetic patients show pronounced endothelial dysfunction. The detected changes in the coagulation system correlate with the severity of periodontitis.
About the Authors
E. A. Shevchenko
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Elena A. Shevchenko, Dr. Sci. (Med.), Professor, Department of Pathological Physiology
Nizhny Novgorod
O. A. Uspenskaya
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Olga A. Uspenskaya, Dr. Sci. (Med.), Head of the Department of Therapeutic Dentistry
Nizhny Novgorod
E. A. Zagrebin
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Evgeny A. Zagrebin, Postgraduate Student, Department of Pathological Physiology
Nizhny Novgorod
S. A. Spiridonova
Privolzhsky Research Medical University
Russian Federation
Russian Federation
Saniya A. Spiridonova, PhD, Associate Professor, Department of Therapeutic Dentistry
Nizhny Novgorod
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Review
For citations:
Shevchenko EA, Uspenskaya OA, Zagrebin EA, Spiridonova SA. Hemostasis disorder as a cause of periodontitis in type II diabetic patients. Parodontologiya. 2021;26(3):240-244. (In Russ.) https://doi.org/10.33925/1683-3759-2021-26-3-240-244
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