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Генетические предикторы развития пародонтита: проблемы и перспективы (обзор литературы)

https://doi.org/10.33925/1683-3759-2022-27-1-32-59

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Аннотация

Актуальность. На сегодняшний день ведутся активные исследования по поиску генетических маркеров пародонтита, обнаружение которых позволит выявлять пациентов группы риска задолго до появления первых признаков заболевания, прогнозировать течение болезни и интенсивно проводить профилактические мероприятия, направленные на устранение негативных факторов окружающей среды.
Цель – систематизация имеющихся данных по изучению ассоциации генов с развитием агрессивного и хронического генерализованного пародонтита.
Материалы и методы. С помощью поисковых систем PubMed, Google Search и eLIBRARY было найдено 214 публикаций, опубликованных с 2005 по 2020 год. Было отобрано 135 публикаций, среди которых встречались клинические исследования и данные метаанализа.
Результаты. Такие хронические воспалительные заболевания, как пародонтит, являются типично полигенными, а ассоциированные с подобными заболеваниями гены рассматриваются как гены предрасположенности. Наличие связанного с заболеванием аллеля у индивидуума не является абсолютным диагностическим признаком для развития заболевания, однако отражает риск его развития. При поиске генетических маркеров пародонтита ключевая роль отводится тем генам, которые кодируют белки, имеющие важные роли на разных этапах патогенеза воспалительных заболеваний пародонта. Среди них: дефензины, интерлейкины, Толл-подобные рецепторы, α1-цепь коллагена I типа и другие. На сегодняшний день изучено порядка 300 полиморфизмов и обнаружена ассоциация некоторых из них с развитием пародонтита.
Заключение. Точный генетический маркер пародонтита на данный момент неизвестен. Дальнейший поиск генов-кандидатов должен проходить параллельно с расширением знаний о патогенезе воспалительных заболеваний пародонта. Определение пресимптоматической предрасположенности к болезни позволит повысить качество оказания стоматологической помощи и проведения профилактических мероприятий еще до появления клинических признаков.

Об авторе

Е. А. Тихомирова
Московский государственный медико-стоматологический университет им. А.И. Евдокимова
Россия

Тихомирова Екатерина Александровна, аспирант кафедры пародонтологии

Москва



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Тихомирова Е.А. Генетические предикторы развития пародонтита: проблемы и перспективы (обзор литературы). Пародонтология. 2022;27(1):32-60. https://doi.org/10.33925/1683-3759-2022-27-1-32-59

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Tikhomirova E.A. Genetic predictors of periodontitis development: problems and prospects (a literature review). Parodontologiya. 2022;27(1):32-60. (In Russ.) https://doi.org/10.33925/1683-3759-2022-27-1-32-59

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