The link between age-related dental syndromes and some oral predictors of ageing

Relevance. Ageing is an important factor causing various diseases and functional failure. Ageing markers help to characterize the ageing process comprehensively. Currently, molecular and genetic human ageing markers are the most promising (Molecular / DNA-Based Markers).
The study aimed to identify the relationship between age-related dental syndromes and some oral predictors of ageing.
Materials and methods. The study included 200 elderly patients, aged 60-74 years, according to the WHO classification. The patients were divided into 3 groups based on the detected clinical dental syndrome (occlusive, periodontal, dystrophic). In all patients, we collected non-stimulated oral fluid. The oral fluid immunochemical examination determined BCL-2 (B Cell Lymphoma 2), Caspase 3, Cytochrome C, GAPDH (Glyceraldehyde 3-Phosphate Dehydrogenase), Cleaved PARP (Poly (ADP-ribose) polymerase) and p53, using the method of the multi-parametric fluorescent analysis with magnetic microspheres.
Results. According to the immunochemical study, the patients with dystrophic syndrome demonstrated the highest concentration of apoptosis markers, with the occlusal syndrome – the lowest. Periodontal syndrome exhibited a moderate level of oral fluid ageing predictors.
Conclusion. Determining the apoptosis marker level in the oral fluid may have practical clinical use in the customized diagnosis of predisposition to the principal age-related dental syndromes, as well as systemic comorbidity. Early diagnosis of diseases at the initial stage allows us to give patients timely recommendations to correct their lifestyle, habits, medication intake.

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