Oral microbial landscape and local defense factors in patients with β-thalassemia major
https://doi.org/10.33925/1683-3759-2022-27-2-134-141
Abstract
Relevance. Oral microbiocenosis, a multi-component system, has specific characteristics during dental and systemic disease development.
Material and methods. The study examined 32 patients with β-thalassemia major and 30 systemically-healthy periodontal patients. The average age of the examined patients was 13-17 years and ≥18 years. We determined the nature of microbiocenosis, which is identified by the spectrum, frequency of occurrence and number of some microorganisms, to establish quantitative and qualitative parameters of normal, commensal and pathogenic oral microorganisms in both groups.
Results. Based on the received data, the mixed oral fluid microbiocenosis structure is qualitatively and quantitatively sufficiently stable in practically healthy subjects; microorganisms are represented by four main genera, namely, Lactobacillus spp., Streptococcus spp., Staphylococcus spp. and Enterobacteriaceae. The oral microflora associated with the development of thalassemia undergoes significant pathological changes with the development of systemic and local immune disorders and dysbiosis. Structural analysis of local defense factors and species representatives of microflora in patients with β-thalassemia major showed that salivary flow rate significantly decreases and the commensal and pathogenic microorganism quantitative and qualitative parameters significantly increase, associated with the comorbidity.
Conclusion. Salivary flow rate significantly decreases, and quantitative and qualitative parameters of commensal and pathogenic microorganisms increase associated with β-thalassemia major. Such conditions lead to the appearance and development of major dental diseases, including inflammatory periodontal diseases.
About the Author
R. V. Shadlinskaya
Azerbaijan Medical University
Azerbaijan
Azerbaijan
Ramida Vagif gizi Shadlinskaya, DMD, PhD, DSc, Associate Professor, Department of Pediatric Dentistry
Baku
References
1. Galanello R, Origa R. Beta-thalassemia. Orphanet Journal of Rare Diseases. 2010;21;5:11. doi: 10.1186/1750-1172-5-11
2. Weatherall DJ. The Evolving Spectrum of the Epidemiology of Thalassemia. Hematology/Oncology Clinics of North America. 2018;32(2):165-175. doi: 10.1016/j.hoc.2017.11.008
3. Asadov C, Abdulalimov E, Mammadova T, Gafarova S, Guliyeva Y, Aliyeva G. Genotype-Phenotype Correlations of β-Thalassemia Mutations in an Azerbaijani Population. Turkish Journal of Hematology. 2017;2;34(3):258-263. doi: 10.4274/tjh.2016.0427
4. Momynaliev K. Thalassemia. Time to prevent! Health. 2012;4(58):42–46. Available from: https://irs-az.com/new/pdf/201210/1349179773464497142.pdf
5. Shadlinskaya RV, Sultanova NN. The anthropometric analysis of parameters of head and face in adults with beta thalassemia major. Morphological newsletter. 2019;27(4):47-54 (In Russ.). doi: 10.20340/mv-mn.19(27).04.47-54
6. Wang SC, Lin KH, Chern JP, Lu MY, Jou S, Lin D, et al. Severe bacterial infection in transfusion – dependent patients with thalassemia major. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. 2003;37(7):984–988. Available from: https://academic.oup.com/cid/article/37/7/984/423473?login=false
7. Wessling–Resnick M. Iron Homeostasis and the Inflammatory Response. Annual review of nutrition. 2010;30:105–122. doi: 10.1146/annurev.nutr.012809.104804
8. Orekhova LYu, Atrushkevich VG, Mikhalchenko DV, Gorbacheva IA, Lapina NV. Dental health and polymorbidity: analysis of modern approaches to the treatment of dental diseases. Parodontologiya. 2017;22(3):15-17 (In Russ.). Available from: https://www.parodont.ru/jour/article/view/121
9. Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and periimplant diseases and conditions – Introduction and key changes from the 1999 classification. Journal of Сlinical Рeriodontology. 2018;45(20):1–8. doi: 10.1111/jcpe.12935
10. Reilkoff RA, Bucala R, Herzog EL. Fibrocytes: emerging effector cells in chronic inflammation. Nature reviews Immunology. 2011;11(6):427–435. doi: 10.1038/nri2990
11. Yu YH, Chasman DI, Buring JE, Rose L, Ridker PM. Cardiovascular risks associated with incident and prevalent periodontal disease. Journal of Сlinical Рeriodontology. 2015;42(1):21–28. doi: 10.1111/jcpe.12335
12. Vasil'eva NA, Bulgakova AI, Imelbaeva EA, Vasilyev EA. Evaluation of local immunity of morbidity of the mutual in the traditional therapy of inflammatory diseases of the parodont. Actual problems in dentistry. 2018;14(3):11–16 (In Russ.). doi: 10.18481/2077-7566-2018-14-3-11-16
13. Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Current opinion in hematology. 2016;23(3):189–197. doi: 10.1097/MOH.0000000000000236
14. Hughes S, Balmer R, Moffat M, Willcoxson F. The dental management of children with congenital heart disease following the publication of Paediatric Congenital Heart Disease Standards and Specifications. British dental journal. 2019;226(6):447–452. doi: 10.1038/s41415-019-0094-0
15. Santosh HN, Chaya D, Aditi B, editors. Anemia of chronic disease and chronic periodontitis. LAP Lambert Academic Publishing. 2014, 100 p.
16. Lukichev МM, Ermolaeva LA. Modern ideas about the role of microflora in pathogenesis of periodontal disease. The Dental Institute. 2018;1(78):92–94 (In Russ.). Available from: https://www.elibrary.ru/download/elibrary_34964799_68497750.pdf
17. Tsarev VN, Nikolaeva EN, Ippolitov EV. Periodontophatogenic bacteria of the main factors of emergence and development of periodontitis. Journal of microbiology epidemiology immunobiology. 2017;5:101-112 (In Russ.). doi: 10.36233/0372-9311-2017-5-101-112
18. Hajishengallis G, Diaz PI. Porphyromonas gingivalis: Immune Subversion Activities and Role in Periodontal Dysbiosis. Current oral health reports. 2020;7(1):12–21. doi: 10.1007/s40496-020-00249-3
19. Vasilyeva NA, Bulgakova AI, Imelbaeva EA, Valeev IV. Clinical and immunological characteristics of local immunity in patients with chronic catarrhal gingivitis. Parodontologiya. 2015;20;3(76):11-17 (In Russ.). Available from: https://www.elibrary.ru/item.asp?id=24365626
20. Bjarnsholt T, Ciofu O, Molin S, Givskov M, Hoiby N. Applying insights from biofilm biology to drug development – Can a new approach be developed? Nature reviews. Drug discovery. 2013;12(10):791–808. doi: 10.1038/nrd4000
21. Rogers SA, Huigens RW 3rd, Cavanagh J, Melander C. Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents. Antimicrobial agents and chemotherapy. 2010;54(5):2112–2118. doi: 10.1128/AAC.01418-09
22. Redinova TL, Pozdeev AR, editors. Clinical methods of saliva examination in dental caries: guidelines for subordinates, interns and dentists. Publishing: Izhevsk State Medical Institute. 1994: 24 p. (In Russ.).
Review
For citations:
Shadlinskaya RV. Oral microbial landscape and local defense factors in patients with β-thalassemia major. Parodontologiya. 2022;27(2):134-141. (In Russ.) https://doi.org/10.33925/1683-3759-2022-27-2-134-141
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