Parameters of immunity in chronic generalized periodontitis in syringomyelia patients

Abstract

To study the conditions of systemic and tissue immunity in chronic generalized periodontitis in syringomyelia patients the research was carried out in two groups of patients. The first group consisted of the chronic generalized periodontitis patients without syringomyelia (experimental group), the second one — of the chronic generalized periodontitis patients with syringomyelia (treatment group). Besides, parallel research was conducted among basically healthy people with intact parodontium. Т-В-cells, antibacterial antibodies to cytoplasmic antigen of staphylococci, A, M, G immunoglobulin of blood serum, the compliment level, lysozyme activity of blood, oral and crevicular fluids, the amount of crevicular fluids, and also the SIgA of oral and crevicular fluids were studied. The examination was done in remission and in the exacerbation phase of chronic generalized periodontitis. Changes in both systemic and tissue immunity were observed in all patients. In syringomyelia patients, however, the changes are specific. In the experimental group patients the reduction of A, M, G serum immunoglobulin was observed while in syringomyelia patients only IgA lowered. The level of IgG increased significantly, and also the tendency towards IgM increase was registered. The changes in cellular component of immune system mainly concerned Т- cells which resulted in the significant reduction of E-rosetting lymphocytes at all severity levels of chronic generalized periodontitis. Among nonspecific resistance factors the reduction of lysozyme and increase of compliment in blood were observed. The level of IgA, SIgA lowered while the level of IgG increased significantly in oral and crevicular fluids.