Immunological study of the cytokine profile in the treatment of patients with red lichen planus mucosa of the oral cavity

Abstract

In this work, an immunological study of the oral fluid of patients with an erosive ulcerous form of red flat lichen was carried out. Patients were comparable by sex, age, clinical manifestations of the inflammatory-dystrophic process in the oral cavity. Patients in the complex treatment used the application of the drug Tizol with L-arginine. The quantitative content of mediators of immunity with pro-inflammatory-interleukin-1 beta (IL-lB), interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-a) was measured by solid-phase enzyme immunoassay (ELISA) a), interferon-alpha (IFN-a) and anti-inflammatory action - interleukin-4 (IL-4) using standard kits according to the manufacturer’s instructions. Control of the effectiveness of treatment of patients with CPL was carried out on the basis of local cytokine profile and immunoglobulins before treatment and on the 3rd, 7th, 14th, 21st day of observation. As a result of drug therapy, a statistically significant decrease in their concentration was observed for all the defined indicators. However, the nature of the change at the observation stages was different.