Oral and dental disease in patients with β-thalassemia
Abstract
β-thalassemia - genetically determined defect in the synthesis of β-chain of hemoglobin causes a chain of interrelated homeostatic disorders, which forms pathogenic preconditions for multiple organ injuries, including the organs and tissues of the oral cavity. The mechanisms of primary inherited diseases, severed by accumulating iatrogenic effects of applied therapy (blood transfusion, Desferal therapy) have significant effects on oral manifestation in patients with β-thalassemia over time. Evidence to this fact were the results of a survey of 88 dental patients of all ages, observed in the Republican Center of thalassemia in Baku. 100% patients in different age groups (Group I: 6-10 years; Group II: 11-15 years; Group III: 16-18 years) were affected by dental disease. So, in group I caries disease was prevailed, in group II high frequency of caries detection competed with the increase of chronic generalized gingivitis, which became prevalent in the older group supervision - Group III. It was observed that with age, frequency of formation of chronic foci of odontogenic infection - apical granulomas, festering cysts was increasing. Detected dynamic of dental disease associated with the homeostatic disturbances in β-thalassemia, requires consideration of the risks and the development of chronic dental disease in two aspects: unanimity of pathogenic mechanisms of dental disease with hereditary hemoglobinopathy and consequences of used treatment methods
References
1. Алексеева И. А. Оценка кариесрезистентности твердых тканей зубов и состояние фосфорно-кальциевого обмена у подростков: Автореф. дис. … канд. мед. наук. - СПб., 2014. - 27 с.
2. Горбачева И. А., Кирсанов А. И. Хроническая одонтогенная очаговая инфекция и соматические заболевания // Пародонтология. 2001. №4. С. 35-39.
3. Давыдов Б. Н., Гаврилова О. А., Зюзькова С. А. Стоматологическая заболеваемость у подростков с различным уровнем здоровья // Стоматология детского возраста и профилактика. 2001. №3. С. 30-32.
4. Елизарова В. М., Петрович Ю. А. Нарушение гомеостаза кальция при множественном кариесе у детей // Стоматология. 2002. № 1.С. 67-71.
5. Леонтьев В. К. Кариес и процессы минерализации. - М.: ММСИ, 2007. - 541 с.
6. Махмудова С. А. Новые подходы к диагностике и лечению бета - талассемии у детей: Автореф. дис. … канд. мед. наук. - СПб. - 27 с.
7. Милехина С. А. Кариес зубов у детей: значение локальных нарушений кальций-фосфорного обмена // Мед. науки. Фундаментальные исследования. 2010. №10. С. 314-318.
8. Орехова Л. Ю., Горбачева И. А., Шестакова Л. А. и др. Механизмы полиорганных поражений у больных воспалительными заболеваниями пародонта на фоне сахарного диабета // Пародонтология. 2011. Т. 16. №2. С. 5-8.
9. Яцкевич Е. Е., Монастырева Э. Г., Сутягина А. А. Состояние твердых тканей зубов у детей с врожденными и наследственными болезнями энергетического обмена // Стоматология детского возраста и профилактика. 2005. №1-2. С. 23-28.
10. Al-Dulayme L. I. Q. Oral Health Status among Iron Deficiency Anemic Children Aged 5 - 13 years in Baghdad - Iraq // M.Sc. The College of Dentistry. Univ. of Baghdad. 2003. №4. P. 23-35.
11. Al-Raheem J. A., Husseen M. A., Raad Salih Al-Ani, Al-Rubayee M. A. H. The Impact of Thalassemia Major on Dental Integrity and Development // M.D.J. 2009. Vol. 6. №4. P. 394-401.
12. Al-Wahdani A. M., Taak D. Q., Al-Omari M. A. O. Dental Disease in Subjects with Beta-Thalassemia Major // Comm. Dent. Oral Epidem. 2002. №20 (6). P. 418-422.
13. Fl-Wahadni A., Qudeimat M. A., Al-Omari M. A. O. Dental arch morphological and dimensional characteristics in jordanial children and young adults with beta-thalassaemia major // International Journal of Pediatric Dentistry. 2005. №15 (2). P. 98-104.
14. Chauhan V. S., Chauhan R. S., Devnar N., Vibhute F., More S. Gingira and Periodontal Diseases in Children and Adolescents // J. Dent and Allie Sci. 2012. №1 (1). P. 26-29.
15. Hattab F. N., Hazzaia A.M., Jassin O. M., Rimaivi H. S. Caries Risk in Patients with Thalassemia Major // Int. Dent. J. 2001. №51 (1). P. 35-38.
16. Hazza,a A. M., Aljamal G. Radiographic Feature of the Jaws and Teeth in Thalassaemia Major // Dentomaxillofacial Radiology. 2006. No 35. P. 283-288.
17. Luglic P. F., Campus G., Dejola C., Mela M. G., Gallisai D. Oral Condition Chemistry of Saliva and Salivary Levels of Streptococcus Mutants in Thalassemia Patients // Clin. Oral Inves. 2002. №6 (4).
18. Chauhan V. S., Chauhan R. S., Devnar N., Vibhute A., More S. Gingiral and Periodontal Diseases in Children and Adolescents // J. Dent. And Allic. Sci. 2012. №1 (1). P. 26-29.
19. Perrotta S., Caprellini M. D., Bertoldo F., Servedio V. Osteoporosis in β-thalassemia major patients: analysis of the genetic background // British Journal of Hematology. 2000. Vol. 111. P. 461-666.
20. Takriti M., Dashash M. Craniofacial parameters of syrian children with β-thalassemia major // Journal of Investigative and Clinical Dentistry. 2011. №2. P. 1-9.
21. Terpos E., Voskaridou E. Treatment Options for Thalassemia Patients with Osteoporosis // Ann. N.Y. Acad. Sci. 2010. №1202. P. 237-243.
22. Thein S. L. Genetic insights into the clinical diversity of beta thalassemia // British Journal of Hematology. 2004. №124. P. 264-274.
23. Thein S. L. Pathophysiology of beta thalassemia - a guide to molecular therapies // The American Society of Hematology. 2005. P. 214-223.
24. Toman H. A., Nasir A., Hassan R. Skeletal, dentoalveolar and soft tissue cephalometric measurements of mulay trasfusion - dependent thalassaemic patients // The European Journal of Orthodontics Advance Access. 2-1. №10 (1093). P. 47-52.
25. Yazigi A., Maalouf G., Inati-Khariati A., Tamin H., Saab C. Bone mineral density in beta - thalassemic lebanese children // J. Musculoskel Neuron Interact. 2002. №2 (5). P. 463-468.
26. Weatherall J. D., Clegg J. B. The Thalassemia Syndromes // The Thalassemia Syndromes. 3-rd Ed. - Oxford: Blackwell, 2001. - P. 132-174.
27. World Health Organization Community Control of Hereditary Anemias // Bull World Health Organ. 2003. Vol. 81. P. 63-80.
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For citations:
. Oral and dental disease in patients with β-thalassemia. Parodontologiya. 2016;21(1):22-25. (In Russ.)
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