Evaluation of the effectiveness of the main systemic antibiotics at the first stage of treatment of generalized aggressive periodontitis
https://doi.org/10.33925/1683-3759-2019-24-3-213-221
Abstract
Relevance: the aims of the study was to compare the effectiveness of the use of various systemic antibiotics in patients with aggressive generalized periodontitis. A comparative study of systemic antibiotic therapy using modern molecular biological methods is important in modern periodontology.
Materials and methods: a prospective, randomized, controlled study of 112 patients with generalized aggressive periodontitis before and after using systemic antibiotics with real-time PCR (GE/ml) of major periodontal pathogens. The median was chosen as a quantitative measure of central tendency. Upper and lower quartiles were used for interval estimation.
Results: moxifloxacin is most effective against Porphyromonas gingivalis (median 102,1 GE/ml) and Tannerella forsythensis (median 103,7 GE/ml). Also effective and reliably suppressed Porphyromonas gingivalis and Treponema denticola when lincomycin was used (medians 103,2, 102,7 GE/ml).
Conclusion: the most effective systemic antibiotics are moxifloxacin and lincomycin, which significantly reduced the number of Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola in periodontal pockets.
About the Authors
T. V. Zakirov
Ural State Medical University
Russian Federation
Russian Federation
E. S. Voroshilina
Ural State Medical University
Russian Federation
Russian Federation
E. V. Brusnitsyna
Ural State Medical University
Russian Federation
Russian Federation
E. S. Ioshchenko
Ural State Medical University
Russian Federation
Russian Federation
N. V. Ozhgikhina
Ural State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Zakirov TV, Voroshilina ES, Brusnitsyna EV, Ioshchenko ES, Ozhgikhina NV. Evaluation of the effectiveness of the main systemic antibiotics at the first stage of treatment of generalized aggressive periodontitis. Parodontologiya. 2019;24(3):213-221. (In Russ.) https://doi.org/10.33925/1683-3759-2019-24-3-213-221
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