Blind randomized clinical trial on studying of oral hygiene and parodentium tissues for 67 people aged from 61 up to 82 years, who had comorbid pathology, suffered from hyposalivation and partial loss of genuine teeth was conducted. The low motivation of caring of an oral cavity at elderly and old people is noted. It is revealed that medical care on negotiability does not allow to improve their oral hygiene and to stop inflammation in a parodentium. At dynamic observation of patients and performance they two times in a year of professional oral hygiene and also as a result of use of the given oral cavity care products for a year (treatment-and-prophylactic toothpaste and conditioner), noted the satisfactory or good level of oral hygiene and remission of inflammatory pathology of the parodentium during all term of observation.

The formation of biofilms by oral bacteria is an important link in the pathogenesis of chronic periodontitis. The study of new approaches for identification and research of biofilms, the search for mechanisms of influence on the formation and destruction of biofilms, is a promising and relevant scientific and practical direction. The aim of the study was to evaluate the course of chronic periodontitis associated with biofilm-forming microorganisms and to study the stability of the biofilm formed by them to enzymes, antiseptics and antibacterial drugs. 97 patients with chronic periodontitis and 30 patients with intact periodontitis were examined. In the study, the properties of 127 clinical isolates isolated in patients with chronic periodontitis and in the control group were studied, DNA of 323 periodontopathogens was determined by real-time PCR. It is established that in patients with chronic periodontitis there are changes in the microflora of the oral cavity: the ability of bacteria to form biofilm increases and their resistance to antibiotics increases. Proteinase K and dimethylsulfoxide possessed the greatest ability to destroy the exopolymer matrix of biofilms.

The article presents the results of the analysis of biochemical changes occurring in the oral mucosa in rats under the influence of bile acid.

The experiment was carried out on 18 male rats of Wistar line. The 1st (control) group included intact animals, the 2nd group carried out applications of litholic acid to the oral mucosa in the form of a gel (1 mg/ml CMC, 2.5%) for 4 hours, in the 3rd-24 hours.

It is established that the application of bile acid causes inflammatory processes in the oral mucosa. In this case, there is a decrease in the level of MDA (p>0.05, p>0.05), accompanied by a significant increase in the activity of the antioxidant enzyme catalase (p>0.05, p<0.05).

The digital values of the API index after application of lithocholic acid significantly increased in all periods of study (p>0.05, p<0.001). Its local effect affects the General somatic status, as evidenced by a significant increase in serum of one of the biochemical markers of inflammation — elastase activity (p>0.05, p<0.05).

Our studies indicate the dual nature of the effects of bile acids on the oral mucous membrane. On the one hand, they activate several inflammatory processes, and on the other, induce activation of protective systems, in this case, the antioxidant system.

The relevance of the research topic. Endothelial dysfunction is the one of key pathogenetic factors of inflammation in the periodontium. It was found, that in CP patients local disturbances of blood flow in periodontal tissues are associated with systemic manifestations of endothelial dysfunction, which are characterized by the vascular wall adhesion molecules expression violations and changes in their soluble forms concentrations in the blood. Periodontal complex therapy normalizes the concentration of soluble forms of adhesion molecules in the bloodstream. Therapeutic treatment of CP is more effective in correcting systemic manifestations of endothelial dysfunction in woman in comparison with men.

Active colony formation and adhesion of microorganisms on the surface of restoration and tissues of the periodontal complex is often an important factor ensuring the development of local and generalized inflammatory processes in the tissues of periodontal, as well as primary and secondary caries. Based on the results of the study, 82% of patients with chronic generalized catarrhal gingivitis were found to have a light degree of colony formation by conditionally pathogenic microorganisms (Klebsiella oxytoca, Streptococcus pyogenes — 3.0 ± 0.3 CFU / ml) of Class 5 restoration surfaces treated with a single-step polishing system Opti1Step ™ Kerr and three-step — Kenda KOMO, Liechtenstein.

The problem of treating inflammatory periodontal diseases in patients with type 2 diabetes, despite significant progress, remains relevant. An essential condition for the treatment of this pathology is the rational use of drugs for local therapy in order to normalize the microbiocenosis of the oral cavity and periodontal tissues, which is facilitated by the individual selection of antiseptic and anti-inflammatory preparations. In this paper, we studied the effectiveness of the therapeutic effects of the Acepta group of drugs in combination with the use of ultrasound methods for local therapeutic and preventive measures in patients with type 2 diabetes.

Now many medicines for treatment of precancer diseases of a mucous membrane of a mouth are known. One of the developing directions of therapy is use of own plasma of patients. The purpose of work I was studying of influence of a plasma therapy on clinical-immunological indicators of patients with an erosive and ulcer form oral lichen planus. 100 patients are examined, from them 47 people with a severe form of oral lichen planus are divided into 2 groups depending on a way of treatment. In the main group in complex therapy injections of autologichny plasma were applied, in control group traditional therapy was carried out. To all patients defined concentration of immunoglobulins of the classes G, A, lysozyme activity of oral liquid and an integrative indicator of Ksb. As a result of a research faster epitelization of pathological elements against the background of a plasma therapy also improvement of indicators of local immunity of a mouth is established, than at standard treatment.

Granular cell tumor (GCT; Abrikossoff’s tumor; Myoblastoma) is a rare tumor that can affect various regions of the body, such as skin, soft tissues, breast, nervous system, gastrointestinal tract, urinary bladder and lungs. GCT in the head and neck region, which represents 45% to 65% of all the involved sites, is encountered most commonly in the oral tongue, especially on its anterior one third. A 36-year-old male, with a chief complaint of a slow-growing mass on the back of the tongue for 2.5 years. It was not associated with pain or dysphagia. There was no history of any significant medical or surgical illness in the past. He was a smoker and social drinker with fair oral hygiene. No cervical lymphadenopathy on regional examination. On intraoral examination, a round mass of about 0.8x0.8 cm on the back of the tongue. The patient was advised for the MRI which showed the round heterogeneous structure with unclear and non-smooth contours. We then performed the wide excision of the mass under GA and the specimen was sent for histopathological examination. postoperative period was uneventful and the lesion healed well. Thus the final diagnosis of Granular Cell tumor of tongue was made. The Tumors cells were immunopositively for S-100 protein and CD68; immunopositively for CKAE1/AE3, Ki67, Desmin. In conclusion: they are 3 important steps in the management rare tumors of the tongue: correct using of diagnostic algorithm, histopathologic examination, using this results for tactics and strategy of managing the patient.

The purpose of this article was to discuss the problem of chronic peri-implantitis from the position of it’s nosological status based on the recent classification of diseases and syndromes. According to basic nosological criteria, including etiological, pathogenetic, pathomorphological, clinical and radiological signs of a disease, chronic peri-implantitis is an inflammatory-destructive process in the implant area, which meets the most of the symptoms of osteomyelitis process. Working hypothesis presented expanding the term “peri-implantitis” to inflammatory-infectious process and further, to nosological status of chronic localized osteomyelitis, will deepen understanding of it’s pathogenesis and give a content to improvement of surgical techniques for restorative treatment of peri-implantitis with increased clinical and prognostic efficacy.

The study of the effectiveness of laser radiation on reparative osteogenesis of the jaw bones is the subject of constant scientific research and research by Russian and foreign scientists. In the review of the literature, multiple meta-analyzes of studies in this field were studied in detail, an analysis of experimental studies on the effect of laser radiation on metabolic processes in the bone tissue of the jaw bones was carried out. The prospects of development of laser technologies for increasing the effectiveness of influence on reparative osteogenesis, possibilities for improvement and standardization of laser therapy protocols for further introduction into clinical practice of new laser technologies are considered in detail. The analysis of scientific literature data allows us to conclude that it is necessary to further improve and develop laser technology for use in complex therapy for remodeling bone tissue in the maxillofacial region.

This article includes description of TMJ-arthroscopy technique. It can reveal us capabilities and advantages of this technique in diagnostic and treatment of temporomandibular joint diseases. We described the indications for the surgical procedure, positive effects, success rate after surgical treatment and frequency of potential complications. The article based on the actual scientific literature and our own clinical experience. Based on the data analysis, we develop some recommendations for surgical treatment and pharmacotherapy, follow-up protocols, and complex rehabilitation of patients with TMJ-pathology.

The paper presents the results of experiments on the free transplantation of xenogeneic membrane for guided bone regeneration. Based on the results of the research these membranes can be recommended for further study in experiments on large animals in orthotopic implantаtion.

A new model for the development, prevention and treatment of oral lichen planus is proposed. The approach to the evaluation of the effectiveness of therapeutic and prophylactic measures in this disease is considered. Based on the clinical studies (350 patients), new system-wide regularities of oral lichen planus were revealed. The relative frequencies and intensities of the transitions of various forms of oral lichen planus from one to the other are estimated for the first time. A method for estimating the moment of saturation of the therapeutic and prophylactic effect of a complex of measures on the oral mucosa with a oral lichen planus with the help of fluorescent diagnostics is suggested. Time characteristics of this moment were determined in the course of treatment, including the administration of drugs (Imudon, Kudesan, Tenoten).

Search of the medicines of local action for treatment of chronic recurrent stomatitis (HRAS) possessing at the same time anesthetizing, regenerating, anti-inflammatory action is relevant. The combination in one means of the medicines relating to various groups, operating on all links of pathogenesis of aftozny stomatitis strengthens and expands a range of use of such medicine. One of the effective remedies of local application having influence on the majority of links of pathogenesis at HRAS is dental Holisal®\gel, on the basis of waterless also the chloride tsetalkoniya is well-cared salycylate. Objective of this research studying of clinical efficiency of Holisal®/gel at the HRAS fibrinozny form at 37 patients at the age of 18-60 years was. clinical efficiency of medicine results of a research in the form of considerable show decrease in a pain syndrome after use of Holisal®\gel for the 2nd days from an initiation of treatment at 94% of patients, reduction of the sizes of an element, its clarification from a raid and emergence of signs of an epitelization in the form of a border on the periphery of a wound by the end of the 1st week at 68% examined.

For a number of systemic diseases accompanied by changes in the state of organs and tissues of the oral cavity, manifested more active over carious diseases, lesions of the oral mucosa and periodontal, dental plaque formation. Correlation analysis carried out in the ratio of chemical elements in dental plaque in patients with essential hypertension (EH), diabetes mellitus (DM) and chronic pyelonephritis (KP). In individuals with different somatic diseases established differences in the ratio of chemical elements in the dental plaque. It proved that for hypertensive patients characterized by an increased content of cadmium, vanadium, selenium, and molybdenum, with reduced content of rubidium, silver, barium and chromium, diabetics have a higher content of copper and cadmium, and patients with chronic pyelonephritis distinguishes high content of cesium, indium, vanadium and arsenic under reduced content of silver, titanium, chromium, manganese and bromine. Solid dental deposits are irritating to the gum, the retention points are for the accumulation of dental plaque, disrupt the process of self-purification of the periodontal pocket. The elemental composition of dental plaque was studied on the equipment, the accredited Academy of Sciences to carry out research of the biological profile.

The study carried out monitoring of equipment and ranking of various physiotherapeutic methods used in dentistry in medical institutions of public health services of different forms of ownership and organization structure in the Udmurt Republic. The frequency of the use of physiotherapeutic methods of treatment in the process of rendering assistance to patients with periodontal diseases has been analyzed, the incidence rate of which remains high every year. An analysis of adherence to the physiotherapeutic method of treatment was carried out, through a sociological study conducted among dentists working in health facilities of different forms of ownership.

The analysis of histological preparations of 35 patients aged 16-25 with boring position of incisors, who underwent orthodontic treatment according to the conventional method using fixed equipment, was carried out in the course of the study. Three groups: 1st — control, 2nd -prior to the imposition of fixed equipment performed vibratome and 3rd — after removing non-removable hardware vibratome was carried out according to standard methods in the Department of maxillofacial surgery and dentistry of Samara state medical University.

Aim. To study the influence of psychoemotional stress on the microbal landscape of the gingival furrow, which is in a state of eubiosis and dysbiosis in students.

The study involved 67 students aged by 17-20 years. As a model of acute psychoemotional stress was used the situation of passing an important exam. A microbiological study was made of the general microbial contamination of the gingival furrow and its colonization by individual microbal species using aerobic and anaerobic cultivation methods.

In the state of relative dormancy, 100% of people without gum disease were found to have an eubiotic condition of the gingival microbal, 100% of persons with catarrhal gingivitis - the microbal of the gingival groove were in a state of dysbiosis.

The influence of the stressor on the disorder of the balance of the microbial homeostasis of the dental gingival slit causes an increase in the imbalance of microbial associations in the form of a decrease in the comensal microflora and an increase in the opportunistic pathogenicity.

Today one of the most urgent problems in periodontics is the choice of drugs that must meet such requirements as high biological compatibility, clinical efficacy and safety for periodontal tissue, which is a morphofunctional complex. This paper presents the results of the application and evaluation of the clinical efficacy of the drug based on hyaluronic acid in the complex treatment of 30 patients with chronic generalized periodontitis. Analysis of the results of clinical examination showed positive dynamics at all stages of treatment, which justifies the use of the drug based on hyaluronic acid as a means of choice in the treatment of periodontal disease.

Severe disorders of the factors of both nonspecific and immune defense of the oral cavity are detected to patients with chronic periodontal diseases on the background of bronchial asthma, with the most significant changes being noted to patients with hormone-dependent bronchial asthma.

To prove the influence of herpesvirus infection on the occurrence of anemia of chronic disease. The study involved 75 people suffering from herpes-viral infection. 3 groups were allocated: the first group (25 people) received acyclovir 1 tablet (200 mg) 5 times a day, 5 days; The 2nd group (25 people) used famvir for 1 tablet (250 mg) 2 times a day, 5 days; The third group (25 people) — famvir 1 tablet (250 mg) 2 times a day, 5 days and kagocel 2 tablets (12 mg) 3 times a day, 5 days. All subjects examined at the time of treatment showed an increase in the content of IL-1β mRNK and TNF-α and a decrease in mRNK of IL-8 and IL-10; on day 14 of the study, a decrease in IL-1β mRNK and TNF-α mRNK and an increase in IL-10 mRNK. In the study of erythrocyte indices — the average volume of erythrocytes and the average hemoglobin content in erythrocyte and the parameters of iron-serum iron metabolism and the total iron binding capacity of the serum, slight deviations from the norm were obtained. Thus, we concluded that the cause of anemia, in addition to the lack of iron, can be chronic herpesvirus infection, and thus timely treatment of a viral infection excludes the use of ferrotherapy.

The level of thiol SH-groups and the activity of glutathione reductase in the oral fluid of patients with non-removable ceramic and cermet structures have been determined.

57 patients with cermet and ceramic non-removable bridges were examined. The average age of the patients was 36.3 ± 3.55 years. The study included patients who did not have more than 3 teeth. A total of 137 non-removable bridges were found, of which 61 were ceramic-metal and 76 ceramics were whole-ceramic. The patients were divided into two groups: group I — 25 patients with cermet removable bridge restorations; Group II — 32 patients with whole-ceramic restorations.

After 6 months. after prosthetics in comparison with the initial, the concentration of thiol groups in patients with cermet prosthesis increased by 21.1%, in patients with ceramic prostheses — by 27.2% (p <0.05). After 6 months. the activity of the enzyme in patients of the I group was higher than the initial activity by 27.4% (p <0.05) and above the activity, which was observed after 7 days, by 21.6%. At this stage of the study, the GR activity was below the control one by 7.8%. In patients of group II after 6 months. after prosthetics, the enzyme activity was higher than the baseline by 45.6% (p <0.05) and 26.4% (p <0.05) higher than 7 days later. In patients with ceramic restorations, GR activity after 6 months. practically did not differ from the control one.

Endothelial dysfunction (ED) is one of the key independent risk factors for the development of diabetes mellitus, inflammatory, autoimmune and tumoral diseases.

Purpose: to study the relationship between the expression of vascular endothelial factor and the number of desquamated endothelial cells in patients with chronic generalized periodontitis (CGP) associated insulin resistance syndrome.

14 practically healthy persons (control) and 72 patients with moderate BPH (24 patients without concomitant diseases, 48 patients with CHP in combination with MS) were examined. Immunoenzymatic methods were used to determine the number of desquamated cells and vascular endothelial growth factor in blood plasma.

In patients with CGP associated MS, an increase in the level of desquamated endothelial blood cells was revealed against a background of a significant increase in the vascular endothelial growth factor, which is caused by dysfunction of the carbohydrate, lipid and hormonal systems.