Relevance: Inflammatory-destructive periodontal diseases are the most complicated and became the main cause of tooth loss in adult population. Herbal medicines have a variety of pharmacological properties, so the development and introduction of new forms for the treatment of inflammatory periodontal diseases is an urgent task today.

Purpose – experimental evaluation of effectiveness of the use of herbal medicines “Tonzinal” and “CM-1” in relation to the priority periodontal pathogenes.

Materials and methods: in experimental studies, the basis for the experiment was the system for the cultivation of microorganisms in real time – the Revers-Spinner RTS-1 bioreactor. With the priority strains of periodontitis pathogens, the study of the growth dynamics of the culture was carried out in several parallels.

Results: herbal medicines “CM-1” and “Tonsinal” has a multilateral therapeutic effect, exerting a diverse influence on the key stages of development of such bacterial populations as Aggregatibacter actinomycetemcomitans, Streptococcus constellatus, Candida albicans.

Conclusion: tan integrated approach in the treatment of patients with inflammatory periodontal diseases is promising and will contribute to a more prolonged remission and increase the effectiveness of treatment.

Relevance: the aim of the research was to optimize the choice of material for fabrication of temporary dentures on isoelastic implants by finite element method.

Materials and methods: four models were constructed of supporting element (basal PEEK implant, crestal PEEK implant and natural tooth in different combination) and in prototype dentures from three different materials. Areas of the maximum voltage in constructions have been revealed and possible loads have been calculated by final element method.

Results: the areas of maximum stress occur in the intraosseous part of implants in all studued cases.

Conclusions: analysis of the data shows that the stresses in crowns is practically independent of the properties of the studied temporary bridges materials. Models 1 and 3 were the strongest. Model 4 was less strong.

Relevance: the aims of the study was to compare the effectiveness of the use of various systemic antibiotics in patients with aggressive generalized periodontitis. A comparative study of systemic antibiotic therapy using modern molecular biological methods is important in modern periodontology.

Materials and methods: a prospective, randomized, controlled study of 112 patients with generalized aggressive periodontitis before and after using systemic antibiotics with real-time PCR (GE/ml) of major periodontal pathogens. The median was chosen as a quantitative measure of central tendency. Upper and lower quartiles were used for interval estimation.

Results: moxifloxacin is most effective against Porphyromonas gingivalis (median 10^2,1 GE/ml) and Tannerella forsythensis (median 10^3,7 GE/ml). Also effective and reliably suppressed Porphyromonas gingivalis and Treponema denticola when lincomycin was used (medians 10^3,2, 10^2,7 GE/ml).

Conclusion: the most effective systemic antibiotics are moxifloxacin and lincomycin, which significantly reduced the number of Porphyromonas gingivalis, Tannerella forsythensis, and Treponema denticola in periodontal pockets.

Relevance: to evaluate the clinical effectiveness of probiotic as an adjunct to professionally administered plaque removal (PAPR) in the treatment of peri-implant mucositis.

Materials and methods: 42 patients with at least 2 implants with peri-implant mucositis and probing depth (PD) of 3-4 mm were selected and randomly divided into two groups. Test group received PAPR plus probiotic powder (Enteflavin^® 4 g), whereas control group received PAPR only. Plaque index (PI), Gingival Index (GI), Bleeding on Probing (BoP), PD were measured at baseline and at days 21, 90, 180 and 360 after treatment.

Results: TEST and control groups involved 21 patients with 61 implants and 21 patients with 59 implants, respectively. All clinical parameters were improved in both groups. Inter-group differences for PI, GI, BoP & PD were found to be statistically significant at all time periods after the treatment in favor of test group (p < 0.05).

Conclusion: PAPR alone or in combination with probiotic powder revealed clinical improvements in peri-implant mucositis patients. Better results were obtained with the adjunctive administration of probiotic. Probiotic therapy may be useful for the prevention and treatment of peri-implant mucositis.

Relevance: among the directions of modern medicine dental implantology is currently experiencing rapid development. To predict the long-term positive result of surgical treatment, it is important to study the content of Pro- and anti-inflammatory cytokines (IL-8, MCP-1, RAIL, TNF) in the gingival fluid and the validity of the use of immunomodulatory drugs after the installation of dental implants.

Purpose – studying the features of changes in the immunoregulatory processes of the mouth cavity when using Imudon medication after dental implantation operation directly into the hole of the removed tooth.

Materials and methods: materials, received during the examination of 83 patients, were used for work (42 menand 41 women), with partial secondary adentia, ages 20 to 50, who were treated in dental clinics of “Medstom”, “Masterdent”, and “Tari” (Saratov city).

Results: received changes of pro inflammatory and anti-inflammatory levels of cytokines of the gingival sulcus in each examined group, with or without the use of Imudon medication, after implant installation, give the base to believe that after the operation in tissues, surrounding implants, form local changes of immunoregulatory processes.

Conclusion: the possibility of early postoperative complications after dental implantation directly into the hole of the removed tooth decreases when prescribing Imudon medication in the first 10 days of the postoperative period.

Relevance: the purpose of this work was to study the effectiveness of proposed treatment and rehabilitation complex for patients with generalized chronic periodontitis and bruxism.

Materials and methods: we examined 73 patients aged 30 to 45 years diagnosed with generalized chronic periodontitis of moderate severity and bruxism. Control group included 15 healthy individuals of the same age for clarify normal functional parameters. Clinical, Doppler flowmetry and electromyographic methods were used for evaluation of the effectiveness of proposed treatment and rehabilitation complex.

Results: the course of treatment resulted in the increase in blood flow perfusion volume by 37.7% (p < 0.05), of blood flow perfusion rate by 58.2% (p<0.05) from baseline values. At the same time, the decrease in bioelectric activity of temporal muscle at rest by 51.82% (p >< 0.05), at voluntary contraction – by 40.4% (p<0.05), the decrease in bioelectric activity of masseter muscle at rest – by 47.4% (p><0.05), at voluntary contraction - by 35.12% (p >< 0.05) from values before treatment, were observed.

Conclusion: data obtained on the basis of electromyography and laser Doppler flowmetry showed that developed treatment and rehabilitation complex is an effective method for correcting the microcirculation in periodontal vessels and the functional activity of the muscles of maxillofacial area.

Relevance: odontogenic infection plays an important role in the development of pregnancy complications, often causing premature birth of the child, as well as limiting its growth and development. According to studies Figueiredo C., Rosalem C., Cantanhede A. found that during pregnancy, women’s organs undergo various physiological, neurological and hormonal changes that occur gradually. In the process of such a restructuring of the body changes the dental status, which determines the correction stages of individual oral hygiene. According to the study Trigolos N. N., Firsova I. V., Makedonova Y. A. and others determined that dental health improves dental status, eliminates the possibility of exacerbation of chronic odontogenic foci of infection, reduces the risk of fetal infection and development of prenatal and postnatal complications, as well as a positive effect on antenatal prevention of dental diseases of the child.

Materials and methods: a total of 216 pregnant women were examined and monitored for a month. To study the hygienic status of women during pregnancy with the pathology of hard tissues of teeth, the hygienic index of green-Vermillion was used. Assessment of the acid-base state of the oral fluid was carried out using the pH meter of the company “Hanna” with a replaceable pH electrode HI 1270. Antimicrobial activity of the hygiene of the mouth was studied with the use of different means of oral hygiene in the process of carrying out hygienic measures to identify maximum efficiency in the selection of funds and the development of “personal hygiene prevention programme”.

Results: the assessment showed an increase in the cleansing effect for the entire period of the study in group 1 from 16.90 ± 3.53% to 49.77 ± 5.62%, in group 2 – from 28.19 ± 3.85% to 64.21 ± 6.32%, in contrast to the control – from 16.14 ± 3.21% to 35.87 ± 5.07%. Indicators of changes in acid-base efficiency of oral fluid were in the 1st group 2.50 ± 0.20, in the 2nd group - 3.21 ± 0.20, and in the 3rd group was 2.38 ± 0.20.

Conclusion: during pregnancy, it is necessary to choose the right hygiene products to ensure oral health and maintain odontogenic infectious status, which eliminates the risk of preterm birth, which threatens a pregnant woman. The importance of odontogenic infection and ways of prevention in women of childbearing age is determined by the development of measures to strengthen dental health and plays a leading role in the planning of individual programs for the prevention of major dental diseases in women of childbearing age.

Relevance: red lichen planus refers to a long, protracted disease with a chronic course. There are a lot of root causes, it is quite difficult to differentiate them. Therefore, pharmacotherapy of this pathology is reduced to the appointment of local drugs that have only symptomatic effects that help accelerate the healing of the oral mucosa.

Purpose – to study reparative regeneration based on the analysis of clinical and cytological examination on the background of the appointment of various methods of pharmacotherapy.

Materials and methods: all patients were divided into two groups using simple randomization: in patients of the first group, betamethasone B was used to treat erosive-ulcerative lesions, which were delivered to the lesion using Tisol, which has conductive transcutaneous activity, using the sandwich technique. The second group of patients used the drug delivery system in the form of a film, which fixed betamethasone B in the lesion area.

Results: were evaluated before treatment, on day 7 and 14. The area and intensity of healing of the oral mucosa were determined, a qualitative and quantitative analysis of cytograms was carried out, which characterizes the dynamics of reparative regeneration of erosions and ulcers.

Conclusion: based on the obtained clinical and laboratory data, it can be concluded that it is advisable to include betamethasone applications in the pharmacotherapy of patients with erosive and ulcerative forms of lichen planus. However, preference should be given to the method of layer-by-layer application of betamethasone B in combination with Tezol.

Relevance: inflammatory processes in the oral mucosa are often found in diseases of the gastrointestinal tract, which is explained by the common functions and unity of all parts of the digestive system.

Purpose – to study the effect of the studied drugs on the state of antioxidant-prooxidant systems of the oral mucosa in patients with chronic pancreatitis.

Materials and methods: we examined 118 patients, of whom 62 were men (mean age 39.6 ± 16.4 years) and 56 women (mean age 40.3 ± 15.7 years); of these, 34 patients (control group) are practically healthy people without somatic pathology and 84 patients with chronic pancreatitis who were divided into two groups. The first (main) group - 46 people who, in addition to the drug therapy prescribed by the gastroenterologist, were prescribed the drug “Multiflora” 1 tablet 1 time per day with meals for 30 days. Also, the patients of the main group, after each meal, rinsed their mouths with “Enoant” food concentrate at a dilution of 1: 5 and applied it inside with 1 tablespoon 2 times a day, diluted with water in a ratio of 1: 5. The second (comparison group) - 38 people who, in addition to treatment of chronic pancreatitis, were treated with the oral mucosa according to the generally accepted method - prescribed fluconazole 150 mg 1 time a day, rinsing with 2% borax solution in glycerol after eating for 14 days. Unstimulated oral fluid of the examined patients served as the material for the study. In all groups, the activity of the catalase enzyme was determined by the method of S.V. Girina (1999), the level of malonic dialdehyde (MDA activity by reaction with thiobarbiturate acid to form a trimethine complex) and antioxidant-prooxidant index of unstimulated oral fluid by the method of А.P. Levitsky (2010). Laboratory research was carried out at the time of the initial examination before the start and on the 30th day of treatment.

Results: in the comparison group after treatment, an increased concentration of malondialdehyde in the oral fluid, as well as reduced indicators of the API index and catalase activity confirm the presence of inflammatory processes in the oral mucosa. The application of the proposed therapeutic complex to patients of the main group significantly reduces the concentration of malondialdehyde in the oral fluid, proving its anti-inflammatory effect on the oral mucosa. An increase in the antioxidant-prooxidant index and an increase in catalase activity indicates an increase in the body’s defenses in patients of the main group.

Conclusion: the use of the proposed therapeutic complex in patients with inflammatory diseases of the oral mucosa suffering from chronic pancreatitis contributes to the elimination of inflammatory and degenerative processes and the restoration of the normal level of protective systems in the oral mucosa.

Purpose – to present the origins of in vivo functional diagnosis of hemomicrocirculation in periodontal tissues in normal and pathological conditions in domestic dentistry.

Materials and methods: the material of the study was archival and reporting materials of research works of scientists-dentists, which deals with the functioning of periodontal tissues. These materials are used as a source of primary information. Analytical, medical and statistical research methods were used to study them.

Results: information on the development and first application in dental practice of methods of in vivo microscopy and microphotography of gums with the clarity that allowed the use of these methods for many years, including modern dentistry. These methods were used for experimental studies in various animals (Guinea pigs, rabbits, cats, dogs) and in clinical practice, in norm and under various extreme effects of General and local character.

Conclusion: the role of domestic scientists and dentists, in particular, the doctor of medical Sciences associate Professor M. K. Gacina, the development of functional methods of research of periodontal: of capillaroscopy and capillaroscopy. The importance of these methods of functional diagnosis of periodontal disease in clinical periodontics at the present stage, including periodontal disease in endocrine pathology, endodontal lesions and tissue pathology around dental implants.

Relevance: the presence of somatic disease is often the main and aggravating factor in development of chronic generalized periodontitis. Treatment of inflammatory periodontal diseases begins with mechanical removal of dental calculus and biofilm on a surface of the teeth. For this purpose along with traditional manual tools are applied sonic ultrasonic, and vibrascalers. Atraumatic and high efficiency of professional oral hygiene complex are extremely important for the treatment of periodontal disease in patients with diabetes. Purpose – to study the effectiveness of professional oral hygiene with use of the Vector apparatus in patients with type 1 diabetes. Materials and methods: this article presents study results of the effectiveness of the Vector ultrasound device use as part of therapeutic and preventive measures complex among 3 patients in different ages with generalized periodontitis and type 1 diabetes mellitus. We conducted a dental and X-ray examination and microbiological analysis of periodontal space contents. All patients underwent professional oral hygiene and Vector-therapy. Results were evaluated after 1 month. Results: using the example of 3 clinical cases, the effectiveness of professional oral hygiene complex was presented. After 4 weeks there were observed the reduction of patients complaints for bleeding gums when brushing teeth, improving hygienic and periodontal indices, reducing the composition and number of periodontal pathogens. Conclusion: treatment of inflammatory periodontal diseases using the Vector system is recommended as an early prevention of the development of a more severe periodontitis, as well as the most benign and minimally invasive treatment for periodontal diseases due to its high effectiveness.

Relevance: the search for ways to improve the efficiency of dental orthopedic rehabilitation of patients with dentition defects is relevant. Most people with overweight and obesity over 45 years old with a high incidence of pathology in the form of partial absence of teeth. Reducing the effectiveness of chewing, taking highly carbohydrate foods contribute to an increase in the growth of plaque, the intensity of the carious process and the deterioration of hygienic indicators of the mouth.

Purpose – to assess the hygienic condition of the oral cavity in patients with an excess of body mass index after orthopedic treatment with removable prostheses.

Materials and methods: the survey was conducted to 57 individuals with excess body mass index (BMI): overweight and obesity at various times after the manufacture of partial removable laminar dentures after 1 month, 3 and 6 months after prosthetics. The dental formula, dentition classification in Kennedy’s modification and mucosa according to Supple, the presence of periodontal diseases, dental indexes were determined by the simplified hygiene index of the oral cavity ОНJ-S (Oral Hygiene Index Simple) and the gingivitis index GI (Gingivitis Index).

Results: When using removable dentures, indicators of oral hygiene indices sharply deteriorated. After the first month of wearing prostheses, the ONJ-S Green index increased by one third, after 3 months and 6 months, it worsened over the period of observation of patients. The Silnes–Low Index increased 1.5 times after a month of wearing a prosthesis, after 3 months – almost 2 times, after 6 months – 3.7 times, which corresponded to moderate gingivitis.

Conclusion: studies have shown that overweight, obese people using removable dentures after prosthetics showed a deterioration in the index indicators – OHJ-S and Silnes–Low in the dynamics during the observation period for patients.